Results 91 to 100 of about 17,169,589 (293)

Black holes in Goedel-type universes with a cosmological constant

, 2004
We discuss supersymmetric black holes embedded in a Goedel-type universe with cosmological constant in five dimensions. The spacetime is a fibration over a four-dimensional Kaehler base manifold, and generically has closed timelike curves. Asymptotically
Behrndt K, Brace D, Brace D Herdeiro C A R Hirano S, Brecher D, Brecher D Danielsson U H Gregory J P Olsson M E, Caldarelli M M, Caldarelli M M, Caldarelli M M, Dietmar Klemm, Dyson L, Gauntlett J P, Gauntlett J P, Gauntlett J P, Gauntlett J P, Gauntlett J P Gutowski J B Suryanarayana N V, Gibbons G W, Gimon E G, Gutowski J B, Gutowski J B Reall H S, Henningson M, Herdeiro C A R, Israel D, Kastor D, Klaus Behrndt, Myers R C, Skenderis K   +25 more
core   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease

Neurobiology of Disease, 2004
We have investigated the effectiveness of transplantation of human neural stem cells into adult rat striatum prior to induction of striatal damage with the mitochondrial toxin 3-nitropropionic acid (3-NP).
Jae K Ryu, Jean Kim, Sung J Cho, Kozo Hatori, Astushi Nagai, Hyun B Choi, Min C Lee, James G McLarnon, Seung U Kim   +8 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

m6A-binding protein YTHDF2 alleviates 3-nitropropionic acid–induced mitochondrial dysfunction of goat granulosa cells

Ecotoxicology and Environmental Safety
3-Nitropropionic acid (3-NP), a mitochondrial complex II inhibitor and prevalent environmental contaminant, has been implicated in female reproductive toxicity, yet its underlying epigenetic mechanisms remain largely unclear.
Dongxu Li, Minghui Zhu, Wenyue Yu, Zhixuan Zhou, Jingwen Wang, Dongyan Liu, Dagan Mao, Feng Wang, Yongjie Wan   +8 more
doaj   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Prediction of Myasthenia Gravis Worsening: A Machine Learning Algorithm Using Wearables and Patient‐Reported Measures

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare disorder characterized by fluctuating muscle weakness with potential life‐threatening crises. Timely interventions may be delayed by limited access to care and fragmented documentation. Our objective was to develop predictive algorithms for MG deterioration using multimodal telemedicine data ...
Maike Stein, Haoqi Sun, Sophie Lehnerer, Lea Gerischer, Maximilian Mönch, Christian Meisel, Andreas Meisel, Pushpa Narayanaswami   +7 more
wiley   +1 more source

Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington's disease-like behavioral, biochemical, and cellular alterations: Restoration of coenzyme-Q10-mediated mitochondrial dysfunction

Indian Journal of Pharmacology, 2018
OBJECTIVE: The aim of the present study was to evaluate the solanesol (SNL)-mediated coenzyme-Q10 restoration to ameliorate 3-nitropropionic (3-NP)-induced behavioral, biochemical, and histological changes which resemble Huntington's disease (HD)-like ...
Sidharth Mehan, Vikramdeep Monga, M. Rani, Rajesh Dudi, K. Ghimire   +4 more
semanticscholar   +1 more source

General Supersymmetric Solutions of Five-Dimensional Supergravity

, 2005
The classification of 1/4-supersymmetric solutions of five dimensional gauged supergravity coupled to arbitrary many abelian vector multiplets, which was initiated in hep-th/0401129, is completed.
C.N. Pope, D. Klemm, E. Witten, E. Witten, I. Bena, J. de Boer, J. Gillard, J.B. Gutowski, J.B. Gutowski, J.M. Maldacena, J.P. Gauntlett, J.P. Gauntlett, J.P. Gauntlett, Jan B Gutowski, O.A.P. Mac Conamhna, S.L. Cacciatori, S.L. Cacciatori, U. Gran, Wafic Sabra, Z.W. Chong, Z.W. Chong   +20 more
core   +1 more source