Results 91 to 100 of about 19,374,224 (331)

Roman spa - sauna world [PDF]

, 2013
Diplomová práce byla vypracována jako návrh interiéru Římských lázní a saunového světa. Římské lázně a saunový svět se nachází ve 3.NP objektu Aquacentra, jehož návrh byl zpracován ve Specializovaném ateliéru ve 2.
Vičánková, Lenka
core  

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Impact of resonance decays on critical point signals in net-proton fluctuations

, 2016
The non-monotonic beam energy dependence of the higher cumulants of net-proton fluctuations is a widely studied signature of the conjectured presence of a critical point in the QCD phase diagram.
A Bazavov, A Bzdak, AM Halasz, B Berdnikov, B Friman, BD Josephson, C Athanasiou, C Downum, C Gale, C Herold, C Nonaka, D Zschiesche, DT Son, F Karsch, G Endrodi, H Fujii, J Berges, J Cleymans, J Fu, J Steinheimer, M Abu-Shady, M Asakawa, M Asakawa, M Asakawa, M Kitazawa, M Nahrgang, M Nahrgang, M Nahrgang, MA Stephanov, MA Stephanov, MA Stephanov, MA Stephanov, Marcus Bluhm, Marlene Nahrgang, O Kaczmarek, P Garg, P Schofield, PC Hohenberg, R Bellwied, R Guida, S Borsanyi, Steffen A. Bass, T Hatsuda, Thomas Schäfer, V Dexheimer, VV Begun, X Luo, Y Aoki   +47 more
core   +3 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Black holes in Goedel-type universes with a cosmological constant

, 2004
We discuss supersymmetric black holes embedded in a Goedel-type universe with cosmological constant in five dimensions. The spacetime is a fibration over a four-dimensional Kaehler base manifold, and generically has closed timelike curves. Asymptotically
Behrndt K, Brace D, Brace D Herdeiro C A R Hirano S, Brecher D, Brecher D Danielsson U H Gregory J P Olsson M E, Caldarelli M M, Caldarelli M M, Caldarelli M M, Dietmar Klemm, Dyson L, Gauntlett J P, Gauntlett J P, Gauntlett J P, Gauntlett J P, Gauntlett J P Gutowski J B Suryanarayana N V, Gibbons G W, Gimon E G, Gutowski J B, Gutowski J B Reall H S, Henningson M, Herdeiro C A R, Israel D, Kastor D, Klaus Behrndt, Myers R C, Skenderis K   +25 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

1266. Characterization of Shifts in Minimum Inhibitory Concentrations During Treatment with Cefiderocol or Comparators in the Phase 3 CREDIBLE-CR and APEKS-NP Studies [PDF]

, 2020
Miki Takemura, Yoshinori Yamano, Yuko Matsunaga, Mari Ariyasu, Roger Echols, Tsutae Den Nagata   +5 more
openalex   +1 more source

More Insight into BDNF against Neurodegeneration: Anti-Apoptosis, Anti-Oxidation, and Suppression of Autophagy

International Journal of Molecular Sciences, 2017
In addition to its well-established neurotrophic action, brain-derived neurotrophic factor (BDNF) also possesses other neuroprotective effects including anti-apoptosis, anti-oxidation, and suppression of autophagy. We have shown before that BDNF triggers
Shang-Der Chen, Chia-Lin Wu, Wei‐Chao Hwang, Ding-I Yang   +3 more
semanticscholar   +1 more source