Results 251 to 260 of about 17,169,589 (293)

Effect of Capsaicin on 3-NP-Induced Neurotoxicity: A Pre-Clinical Study

Neurochemical Research
The study objectives are to investigate the ability of capsaicin to revert the toxic effects in glutamate and lipopolysaccharide (LPS)-induced neurotoxicity in Neuro2a (N2a) cells as well as thwarting cognitive impairments, mitochondrial deficits, and oxidative insults induced by 3-nitropropanoic acid (3-NP) in a rodent model of Huntington's disease ...
S. Tyagi, A. Thakur
semanticscholar   +3 more sources

Characteristic Changes of Astrocyte and Microglia in Rat Striatum Induced by 3-NP and MCAO

Neurochemical Research, 2016
Our previous studies had confirmed that both 3-NP and MCAO induced the behavioral defect as well as striatal neuronal injury and loss in experimental rats. This study aimed to examine different response forms of striatal astrocyte and microglia in 3-NP and MCAO rat models.
Shuhua Mu, Bingbing Liu, Lisi Ouyang, Mali Zhan, Si Chen, Jiajia Wu, Jiachang Chen, Xianyou Wei, Weiping Wang, Jian Zhang, W. Lei   +10 more
semanticscholar   +3 more sources

Preferential interneuron survival in the transition zone of 3‐NP‐induced striatal injury in rats

Journal of Neuroscience Research, 2011
AbstractHistology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, and marker protein expression of striatal interneurons in the transition zone of striatal injury induced by 3‐NP. The 3‐NP treatment in rats yielded movement, motor coordination, and cognitive dysfunction.
Shuhua Mu, Lisi Ouyang, Bingbing Liu, Yaxi Zhu, Keyi Li, Mali Zhan, Zongwei Liu, Yu-Hong Jia, W. Lei, Anton Reiner   +9 more
semanticscholar   +3 more sources

NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease.

NeuroReport, 1996
Nerve growth factor (NGF)-secreting fibroblasts are able to protect against the Huntington-like striatal neurodegeneration induced by the mitochondrial toxin 3-nitropropionic acid (3-NP). In the present study, we investigated whether the neuroprotective effects of NGF are mediated through antioxidative mechanisms.
Wendy Galpern, Russell T. Matthews, M. Beal, Ole Isacson   +3 more
semanticscholar   +4 more sources

Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism

Neurochemical Research, 2015
3-Nitropropionic acid (3-NP) is a fungal toxin well established model used for inducing symptoms of Huntington's disease. Curcumin a natural polyphenol has been reported to possess neuroprotective activity by decreasing oxidative stress. The aim of present study was to investigate neuroprotective effect of curcumin with piperine (bioavailability ...
Shamsher Singh, Sumit Jamwal, Puneet Kumar   +2 more
semanticscholar   +3 more sources

Cystamine and cysteamine prevent 3‐NP‐induced mitochondrial depolarization of Huntington's disease knock‐in striatal cells

European Journal of Neuroscience, 2006
AbstractCystamine significantly improved motor deficits and extended survival in mouse models of Huntington's disease (HD); however, the precise mechanism(s) by which cystamine and the related compound cysteamine are beneficial remain to be elucidated.
Zhengkuan Mao, Yeun Su Choo, M. Lesort
semanticscholar   +3 more sources

Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters

Physiology & Behavior, 2016
Spermidine, a naturally occurring polyamine, is involved in various internal biological functions, due to its antioxidant and anti-inflammatory properties. A decreased level of polyamines is associated with aging and neurodegenerative disorders including Huntington disease (HD).
Sumit Jamwal, Puneet Kumar
semanticscholar   +3 more sources

Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats

Brain Research Bulletin, 2005
Nicotinic acetylcholine receptors (nAChRs) are regarded as potential therapeutic targets to control various neurodegenerative diseases. Owing to the relevance of cholinergic neurotransmission in the pathogenesis of Huntington's disease (HD) this investigation was aimed to study the effect of nicotine, a nAChR agonist, on 3-nitropropionic acid (3-NP ...
M. Tariq, H. Khan, I. Elfaki, S. Deeb, K. Moutaery   +4 more
semanticscholar   +3 more sources

Neuroprotective effect of standardized extracts of three Lactuca sativa Linn. varieties against 3-NP induced Huntington’s disease like symptoms in rats

Nutritional Neuroscience, 2020
Objectives The study was aimed to evaluate the efficacy of three commonly consumed Lactuca sativa (LS) Linn. varieties viz., Grand rapid, Lollo rosso and Iceberg (Asteraceae) against 3-NP induced HD like symptoms in rats.
J. Malik, Supreet Kaur, M. Karan, Sunayna Choudhary   +3 more
semanticscholar   +3 more sources

Protective effect of minocycline, a semi-synthetic second-generation tetracycline against 3-nitropropionic acid (3-NP)-induced neurotoxicity.

Toxicology, 2008
3-Nitropropionic acid (3-NP) is an irreversible inhibitor of the electron transport enzyme succinate dehydrogenase, a mitochondrial Complex II enzyme. Minocycline is a semi-synthetic second-generation tetracycline with neuroprotective activity and has the capability to effectively cross the blood-brain barrier.
M. Ahuja, M. Bishnoi, K. Chopra
semanticscholar   +3 more sources