Results 261 to 270 of about 13,770,514 (290)

NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntingtonʼs disease

NeuroReport, 1996
Nerve growth factor (NGF)-secreting fibroblasts are able to protect against the Huntington-like striatal neurodegeneration induced by the mitochondrial toxin 3-nitropropionic acid (3-NP). In the present study, we investigated whether the neuroprotective effects of NGF are mediated through antioxidative mechanisms.
Galpern, Wendy R., Matthews, Russell T., Beal, M. Flint, Isacson, Ole   +3 more
openaire   +3 more sources

Protective effect of melatonin on 3-NP induced striatal interneuron injury in rats

Neurochemistry International, 2011
To confirm the effect of melatonin on 3-nitropropionic acid (3-NP)-induced striatal interneuron injury in rats, behavioral test, histology, immunohistochemistry and Western blotting were respectively used to characterize the behavioral changes of experimental animals in motor and cognition, the morphological changes of striatal interneurons and the ...
Shuhua, Mu, Lisi, OuYang, Bingbing, Liu, Yaxi, Zhu, Keyi, Li, Mali, Zhan, Zongwei, Liu, Yu, Jia, Wanlong, Lei   +8 more
openaire   +2 more sources

STIM1, STIM2, and PDI Participate in Cellular Fate Decisions in Low Energy Availability Induced by 3-NP in Male Rats

Neurotoxicity Research, 2021
Impairment in the energetic function of mitochondria is seen in many neurologic disorders like neurodegeneration. It disrupts ATP production, gives rise to oxidative stress, and ultimately challenges the viability of neurons. In this situation, neural cells use complex crosstalk between various subcellular elements to make live-or-die decisions about ...
Nazila Iranipour, Farrin Babaei-Balderlou, Ali Maleki, Mehdi Moslemi, Fariba Khodagholi   +4 more
openaire   +2 more sources

Study on the aerobic biodegradability and degradation kinetics of 3-NP; 2,4-DNP and 2,6-DNP

Journal of Hazardous Materials, 2012
Four biodegradability tests (BOD(5)/COD ratio, production of carbon dioxide, relative oxygen uptake rate and relative enzymatic activity) were used to determine the aerobic biodegradability of 3-nitrophenol (3-NP), 2,4-dinitrophenol (2,4-DNP) and 2,6-dinitrophenol (2,6-DNP).
Zonglian, She, Tian, Xie, Yingjie, Zhu, Leilei, Li, Gaifeng, Tang, Jian, Huang   +5 more
openaire   +2 more sources

Preferential interneuron survival in the transition zone of 3‐NP‐induced striatal injury in rats

Journal of Neuroscience Research, 2011
AbstractHistology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, and marker protein expression of striatal interneurons in the transition zone of striatal injury induced by 3‐NP. The 3‐NP treatment in rats yielded movement, motor coordination, and cognitive dysfunction.
Shuhua, Mu, Lisi, OuYang, Bingbing, Liu, Yaxi, Zhu, Keyi, Li, Mali, Zhan, Zongwei, Liu, Yu, Jia, Wanlong, Lei, A, Reiner   +9 more
openaire   +2 more sources

The 3‐NP Model of Striatal Neurodegeneration

Current Protocols in Neuroscience, 2014
AbstractThe mitochondrial toxin 3‐nitropropionic acid (3‐NP) is an irreversible inhibitor of respiratory chain complex II. Chronic systemic administration of 3‐NP to mice, rats, and non‐human primates leads to preferential degeneration of the striatum, and produces motor and cognitive symptoms that are highly reminiscent of Huntington's disease (HD ...
openaire   +2 more sources

Effect of Capsaicin on 3-NP-Induced Neurotoxicity: A Pre-Clinical Study

Neurochemical Research
The study objectives are to investigate the ability of capsaicin to revert the toxic effects in glutamate and lipopolysaccharide (LPS)-induced neurotoxicity in Neuro2a (N2a) cells as well as thwarting cognitive impairments, mitochondrial deficits, and oxidative insults induced by 3-nitropropanoic acid (3-NP) in a rodent model of Huntington's disease ...
Sakshi Tyagi, Ajit Kumar Thakur
openaire   +2 more sources

Cystamine and cysteamine prevent 3‐NP‐induced mitochondrial depolarization of Huntington's disease knock‐in striatal cells

European Journal of Neuroscience, 2006
AbstractCystamine significantly improved motor deficits and extended survival in mouse models of Huntington's disease (HD); however, the precise mechanism(s) by which cystamine and the related compound cysteamine are beneficial remain to be elucidated.
Zhengkuan, Mao, Yeun Su, Choo, Mathieu, Lesort   +2 more
openaire   +2 more sources

Neuroprotective effect of nicotine against 3-nitropropionic acid (3-NP)-induced experimental Huntington's disease in rats

Brain Research Bulletin, 2005
Nicotinic acetylcholine receptors (nAChRs) are regarded as potential therapeutic targets to control various neurodegenerative diseases. Owing to the relevance of cholinergic neurotransmission in the pathogenesis of Huntington's disease (HD) this investigation was aimed to study the effect of nicotine, a nAChR agonist, on 3-nitropropionic acid (3-NP ...
Mohammad, Tariq, Haseeb Ahmad, Khan, Ibrahim, Elfaki, Saleh, Al Deeb, Khalaf, Al Moutaery   +4 more
openaire   +2 more sources

Piperine Enhances the Protective Effect of Curcumin Against 3-NP Induced Neurotoxicity: Possible Neurotransmitters Modulation Mechanism

Neurochemical Research, 2015
3-Nitropropionic acid (3-NP) is a fungal toxin well established model used for inducing symptoms of Huntington's disease. Curcumin a natural polyphenol has been reported to possess neuroprotective activity by decreasing oxidative stress. The aim of present study was to investigate neuroprotective effect of curcumin with piperine (bioavailability ...
Shamsher, Singh, Sumit, Jamwal, Puneet, Kumar   +2 more
openaire   +2 more sources