Results 71 to 80 of about 17,169,589 (293)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

NP-ПОЛНОТА В СИЛЬНОМ СМЫСЛЕ ЗАДАЧИ «3-РАЗБИЕНИЕ ПРОИЗВЕДЕНИЯ»

Informatika, 2018
Доказывается NP-полнота в сильном смысле задачи 3-РАЗБИЕНИЕ ПРОИЗВЕДЕНИЯ.В этой задаче дано множество из 3m элементов A={a1, a2, …, a3m} и для каждого элемента ai дан его размер s(ai)∈Z+.

doaj  

Extraction of Silicon-Containing Nanoparticles from an Agricultural Soil for Analysis by Single Particle Sector Field and Time-of-Flight Inductively Coupled Plasma Mass Spectrometry

Nanomaterials, 2023
The increased use of silica and silicon-containing nanoparticles (Si-NP) in agricultural applications has stimulated interest in determining their potential migration in the environment and their uptake by living organisms.
Zhizhong Li, Madjid Hadioui, Kevin J. Wilkinson   +2 more
doaj   +1 more source

Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine

Journal of Neuroscience, 2000
Glutathione peroxidase (GSHPx) is a critical intracellular enzyme involved in detoxification of hydrogen peroxide (H2O2) to water. In the present study we examined the susceptibility of mice with a disruption of the glutathione peroxidase gene to the ...
P. Klivényi, Ole A. Andreassen, R. Ferrante, A. Dedeoglu, Gerald Mueller, E. Lancelot, M. Bogdanov, Julie K. Andersen, D. Jiang, M. Beal   +9 more
semanticscholar   +1 more source

Dryland maize yields and water use efficiency in response to tillage and nutrient management practices in China [PDF]

, 2009
Rainfed crop production in northern China is constrained by low and variable rainfall. This study explored the effects of tillage and nutrient management practices on maize (Zea mays L.) yield and water use efficiency (WUE), at Shouyang Dryland Farming ...
Cai, D.X., Dai, K., Hoogmoed, W.B., Oenema, O., Wang, X.B., Zhao, Q.   +5 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells

Particle and Fibre Toxicology, 2010
Background Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood.
Bhattacharjee Sourav, de Haan Laura HJ, Evers Nynke M, Jiang Xue, Marcelis Antonius TM, Zuilhof Han, Rietjens Ivonne MCM, Alink Gerrit M   +7 more
doaj   +1 more source

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

Journal of Neuroscience, 1993
An impairment of energy metabolism may underlie slow excitotoxic neuronal death in neurodegenerative diseases. We therefore examined the effects of intrastriatal, subacute systemic, or chronic systemic administration of the mitochondrial toxin 3 ...
M. Beal, E. Brouillet, B. Jenkins, R. Ferrante, N. Kowall, Joanne M. Miller, E. Storey, R. Srivastava, B. Rosen, B. Hyman   +9 more
semanticscholar   +1 more source

Normal type-2 Fuzzy Rational B-Spline Curve

, 2013
In this paper, we proposed a new form of type-2 fuzzy data points(T2FDPs) that is normal type-2 data points(NT2FDPs). These brand-new forms of data were defined by using the definition of normal type-2 triangular fuzzy number(NT2TFN).
Gobithaasan, R. U., Wahab, Abd. Fatah, Zakaria, Rozaimi   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source