Results 71 to 80 of about 19,374,224 (331)
Nonperturbative hyperfine contribution to the $b_1$ and $h_1$ meson masses [PDF]
, 2001 Due to the nonperturbative contribution to the hyperfine splitting the mass of the $n^1P_1$ state is strongly correlated with the center of gravity $M_{\rm cog}(n^3P_J)$ of the $n^3P_J$ multiplet: $M(n^1P_1)$ is less than $M_{\rm cog}(n^3P_J)$ by about ...
A. Di Giacomo +29 more
core +5 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Early Prediction of Long-Term Response to Cabergoline in Patients with Macroprolactinomas [PDF]
Endocrinology and Metabolism, 2014 BackgroundCabergoline is typically effective for treating prolactinomas; however, some patients display cabergoline resistance, and the early characteristics of these patients remain unclear.
Youngki Lee +5 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Effects of 3-nitrpropionic acid in rats: general toxicity and neurotoxicity [PDF]
, 2005 Three-nitropropionic acid (3-NP) causes biochemical and morphological alterations in human and animal brain. Young adult male Wistar rats received 3-NP ip. on 5 consecutive days and were investigated four weeks later (subacute treatment).
Nagymajtényi, László +2 more
core
Two Species Evolutionary Game Model of User and Moderator Dynamics
, 2012 We construct a two species evolutionary game model of an online society consisting of ordinary users and behavior enforcers (moderators). Among themselves, moderators play a coordination game choosing between being "positive" or "negative" (or harsh ...
Fan, James +3 more
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
The FASEB Journal, 2009 The 3‐nitropropionic acid model Of Huntington's disease produces a variety of biochemical anomalies. One of these, is the activation of the protease calpain. Excess calpain activity is probably responsible for major cell death expressed as striatial degeneration.
Leo Kesner +5 more
openaire +1 more source
Altered stimulus frequency and intensity dependence of the somatosensory evoked potential in rats after acute application of two mitochondrial toxins [PDF]
, 2009 Mitochondrial toxins are a special group of toxicants with nervous system ef TRACT - fects. The resulting nervous system damage could be detected and followed-up by means of functional biomarkers but these still have to be worked out.
Bankó, S., Papp, András, Takács, Sz.
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source