Results 91 to 100 of about 11,467,373 (235)

Party Systems in Latin America after the Third Wave: A Critical Re-assessment Sistemas de partidos en América Latina después de la tercera ola de democratización: un análisis crítico

open access: yesJournal of Politics in Latin America, 2012
This essay calls for a more nuanced analysis of the evolution of party systems in Latin America. First, I contend that the general impression that party systems are collapsing in Latin America and that processes of partisan and electoral dealignment are ...
Miguel Carreras
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

Book Review: Mertha, Andrew: Brothers in Arms: Chinese Aid to the Khmer Rouge, 1975–1979

open access: yesJournal of Current Southeast Asian Affairs, 2015
Book Review of the Monograph: Mertha, Andrew (2014), Brothers in Arms: Chinese Aid to the Khmer Rouge, 1975–1979.
Chow Bing NGEOW
doaj  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

A Folha, Ano 6, Número 300

open access: yes, 1978
Folheto publicado pela Cúria Diocesana de Nova Iguaçu de 1977 a 1984 com foco nas questões políticas e sociais que afetavam a vida dos habitantes da Baixada Fluminense, a partir da perspectiva da doutrina Cristã.
Hypólito, Dom Adriano Mandarino
core  

The Crux Is the Skin: Reflections on Southeast Asian Personhood

open access: yesJournal of Current Southeast Asian Affairs, 2011
This essay is an exercise in the phenomenology of personhood based on some 25 years of field research among Javanese, Thai, and Filipinos. As I still slip up from time to time, I am convinced that it is relevant to both scholarly researchers and others ...
Niels Mulder
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Book Review: Haberkorn, Tyrell, Revolution Interrupted: ...

open access: yesJournal of Current Southeast Asian Affairs, 2012
Book Review of the monograph: Haberkorn, Tyrell (2011), Revolution Interrupted: Farmers, Students, Law and Violence in Northern Thailand Madison, Wisconsin: University of Wisconsin Press, ISBN: 978 0 299 28184 7, 256 ...
Fabian Drahmoune
doaj  

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

open access: yesMolecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba   +5 more
wiley   +1 more source

مقدمة العدد 300 أكتوبر الجزء الثاني . [PDF]

open access: yesمجلة القراءة والمعرفة
مقدمة العدد 300 أكتوبر الجزء الثاني .
doaj   +1 more source

Home - About - Disclaimer - Privacy