Results 101 to 110 of about 755,225 (262)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Cold exposure induces different uncoupling-protein thermogenin masking/unmasking processes in brown adipose tissue depending on mitochondrial subtypes

, 1994
The effect of cold exposure on thermogenic parameters such as mitochondrial protein content, GDP-binding and uncoupling protein (UCP) levels in different mitochondrial fractions from rat brown adipose tissue has been investigated.
LANNI, Antonia, Puigserver P, Gianotti M, Goglia F, 300:463 8, Llull J, Moreno M, Palou A. Biochem J. 1994 Jun 1   +7 more
core   +1 more source

From Top To Bottom (and Back To The Top Again): Federal Spending, Sub-national Coalitions, and Protests in Argentina, 2002–2006 De arriba abajo (y vuelta arriba otra vez). Gasto federal, coaliciones subnacionales y protesta en Argentina, 2002-2006

Journal of Politics in Latin America, 2012
Can federal-state relations affect popular protests? Using an extensive dataset measuring local protests in the Argentine provinces (2002–2006), I assess the effects of the president’s and governors’ tactical allocations on the persistence of contentious
Lorena Moscovich
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

KONDISI SEIMBANG UNTUK ROKET RKX-300-LPN

, 1994
Ringkasan Kondisi seimbang (trim condition) suatu roket merupakan batas kondisi stabil clan tidak stabil pada saat terbang sehingga pejumlahan koefisien momen yang terjadi terhadap titik berat roket sama dengan nol.
Endang Sumartinah;, Salam Ginting
core  

From the Editor’s Desk

Journal of Current Southeast Asian Affairs, 2010
From the Editor’s Desk. Introduction. Editorial.
Marco Bünte, David Camroux
doaj  

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

PREDIKSI STATIK MARJIN ROKET RKX-300-LPN UNTUK POSISI SAYAP YANG BERBEDA

, 1994
Ringkasan RKX-300-LPN merupakan test vehicle untuk pengujian terbang sistem kendali wahana peluncur. Dengan posisi sayap roket yang dapat dirubah, maka karakteristik dinamik roket dapat dirubah pula, termasuk statik marjinnya.
Errya Satrya, Edi Sofyan
core  

Introduction: The Massacres of 1965–1966: New Interpretations and the Current Debate in Indonesia

Journal of Current Southeast Asian Affairs, 2013
The mass violence which spread across Indonesia following an attempt-ed coup on 1 October 1965 claimed the lives of half a million people and irrevocably changed the lives of millions more.
Annie Pohlman
doaj  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source