Results 71 to 80 of about 11,467,373 (235)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Stable and Reusable Light-Responsive Reduced Covalent Organic Framework (COF-300-AR) as a Oxidase-Mimicking Catalyst for GSH Detection in Cell Lysate

, 2020
Covalent organic frameworks (COFs), as one of the most significant members of the porous organic frameworks, have been well used in the photocatalysis owing to their outspread π-conjugated framework, high crystallinity and regular pore structure. Herein,
Weifeng Wang, Kui Dong (8747232), Xingguo Chen, Huige Zhang (4693150), Kui Dong, Huige Zhang, Fang Zhang, Fang Zhang (197215), Weifeng Wang (83822), Xingguo Chen (1439194), Xiaoying Niu, Xiaoying Niu (8747229), Hongli Chen, Hongli Chen (288278), Hongxia Dai, Peng Jin (216301), Hongxia Dai (8747235), Peng Jin   +17 more
core   +1 more source

The Media Politics of Latin America’s Leftist Governments La política de medios de los gobiernos de izquierda en América Latina

Journal of Politics in Latin America, 2012
Does Latin America’s left turn matter in media politics? Has ideology any impact on governments’ practices and policies regarding media and journalistic institutions? This essay focuses on the existence of a specific kind of media activism on the part of
Philip Kitzberger
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Towards the ASEAN Community: Assessing the Knowledge, Attitudes, and Aspirations of Thai University Students

Journal of Current Southeast Asian Affairs, 2016
This article assesses the knowledge of, attitudes towards, and aspirations for ASEAN among Thai university students, who are set to enter the ASEAN Community labour market and are among those most in touch with ASEAN issues.
Pinn Siraprapasiri, Chanintira na Thalang   +1 more
doaj  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

300°C.

, 2022
300°C.
Ke Gao (1521607), Shengnan Li (345816), Xiaoqi Wang (164823), Heng Ma (240045), Xuesong Yang (175061), Xiaohan Qi (12107098)   +5 more
core   +1 more source

The Internationalisation of Mainland Chinese Firms into Malaysia: From Obligated Embeddedness to Active Embeddedness

Journal of Current Southeast Asian Affairs, 2014
This paper examines the rationale by which mainland Chinese firms choose their coalition partners in their Malaysian ventures. I explore how, under certain political economic conditions, such cross-border investment and corporate tie-ups can be shaped to
Guanie LIM
doaj  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

LIPIcs, Volume 300, CCC 2024, Complete Volume

LIPIcs, Volume 300, CCC 2024, Complete ...
Santhanam, Rahul
core   +1 more source