Results 71 to 80 of about 10,786,653 (337)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Jakartans, Institutionally Volatile

Journal of Current Southeast Asian Affairs, 2014
Jakarta recently has gained even more central political attention in Indonesia since Joko Widodo (Jokowi) and Basuki Purnama (Ahok) became, respectively, the province’s governor and vice-governor in 2012.
Masaaki OKAMOTO
doaj  

Hectospec, the MMT's 300 Optical Fiber-Fed Spectrograph

, 2005
The Hectospec is a 300 optical fiber fed spectrograph commissioned at the MMT in the spring of 2004. A pair of high-speed six-axis robots move the 300 fiber buttons between observing configurations within ~300 s and to an accuracy ~25 microns.
Andrew Szentgyorgyi, Brian McLeod, Daniel Fabricant, Deborah Woods, Douglas Mink, Edward Hertz, Epps H., Fabricant D., Harland Epps, Henry Bergner, Ian Dell’Antonio, Jack Barberis, John Geary, John Roll, Joseph Zajac, Margaret Geller, Mark Mueller, Mark Ordway, Maureen Conroy, Michael Honsa, Michael Kurtz, Nelson Caldwell, Parry I., Richard Goddard, Robert Fata, Roger Eng, Susan Tokarz, Thomas Gauron, Warren Brown, William Wyatt, Wyse R. F. G.   +30 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Review: Askew, Mark (ed.): Legitimacy Crisis in Thailand

Journal of Current Southeast Asian Affairs, 2011
Review of the edited volume: Askew, Mark (ed.) (2010), Legitimacy Crisis in Thailand, Chiang Mai, Thailand: Silkworm Books (= King Prajadhipok’s Institute Yearbook No. 5 (2008/09)).
Napisa Waitoolkiat
doaj  

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

The Role of Religion and Ethnicity in Jakarta’s 2012 Gubernatorial Election

Journal of Current Southeast Asian Affairs, 2014
The victory of Joko Widodo (‘Jokowi’) in Jakarta’s 2012 gubernatorial election has been described as a “triumph of democracy” as Joko and his running mate Basuki Tjahaja Purnama (‘Ahok’), a Chinese Christian, successfully won the election ...
Ken Miichi
doaj  

Microwave-mediated synthesis of N-methyliminodiacetic acid (MIDA) boronates [PDF]

, 2014
A library of over 20, mainly aryl or heteroaryl, N-methyliminodiacetic acid (MIDA) boronates have been synthesised. A rapid microwave-mediated (MW) method (5–10 min) has been developed using polyethylene glycol 300 (PEG 300) as solvent.
Close, Adam J, Emmerson, Matthew K, Kemmitt, Paul, Spencer, John   +3 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Burmese Attitude toward Chinese: Portrayal of the Chinese in Contemporary Cultural and Media Works

Journal of Current Southeast Asian Affairs, 2012
This paper argues that since at least the mid 1980s, there has been an observable negative attitude among the people of Burma against the Chinese. Such sentiment is not just transient public opinion, but an attitude.
Min Zin
doaj