Results 61 to 70 of about 2,407,583 (266)
The Crux Is the Skin: Reflections on Southeast Asian Personhood
Journal of Current Southeast Asian Affairs, 2011 This essay is an exercise in the phenomenology of personhood based on some 25 years of field research among Javanese, Thai, and Filipinos. As I still slip up from time to time, I am convinced that it is relevant to both scholarly researchers and others ...
Niels Mulder
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Book Review: Haberkorn, Tyrell, Revolution Interrupted: ...
Journal of Current Southeast Asian Affairs, 2012 Book Review of the monograph: Haberkorn, Tyrell (2011), Revolution Interrupted: Farmers, Students, Law and Violence in Northern Thailand Madison, Wisconsin: University of Wisconsin Press, ISBN: 978 0 299 28184 7, 256 ...
Fabian Drahmoune
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Journal of Politics in Latin America, 2010 Ideology, typically defined on a left-right spectrum, should provide a means of communication between elites and masses. After years of leftist party rule, have Brazilian voters internalized ideological divisions? Longitudinal surveys conducted from 2002
Barry Ames, Amy Erica Smith
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Governance Obstacles to Geothermal Energy Development in Indonesia
Journal of Current Southeast Asian Affairs, 2015 Despite having 40 per cent of the world’s potential for geothermal power production, Indonesia exploits less than five per cent of its own geothermal resources.
Matthew S. Winters, Matthew Cawvey
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Resilience of the Communist Party of Vietnam’s Authoritarian Regime since Doi Moi
Journal of Current Southeast Asian Affairs, 2016 Unlike communist parties in the former Soviet Union and Eastern and Central Europe, the Communist Party of Vietnam (CPV) has overcome crises to remain in power for the last 30 years and will most likely continue ruling in the coming decades.
Hai Hong NGUYEN
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source