Results 51 to 60 of about 1,006,472 (231)

The Role of Religion and Ethnicity in Jakarta’s 2012 Gubernatorial Election

Journal of Current Southeast Asian Affairs, 2014
The victory of Joko Widodo (‘Jokowi’) in Jakarta’s 2012 gubernatorial election has been described as a “triumph of democracy” as Joko and his running mate Basuki Tjahaja Purnama (‘Ahok’), a Chinese Christian, successfully won the election ...
Ken Miichi
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Punjabi 300 : Barjinder Dhillon Interview

, 2013
Raw footage for "Punjabi 300: The Komagata Maru - A Continuing Journey." This interview brings in Barjinder Dhillon's perspective on the Komagata Maru incident.Arts, Faculty ofAsian Studies, Department ...
Gedda, Peder, Joshi, Abhijeet, Dhaliwal, Satinder, Ghuman, Jushin, Attri, Prateek   +4 more
core   +1 more source

Burmese Attitude toward Chinese: Portrayal of the Chinese in Contemporary Cultural and Media Works

Journal of Current Southeast Asian Affairs, 2012
This paper argues that since at least the mid 1980s, there has been an observable negative attitude among the people of Burma against the Chinese. Such sentiment is not just transient public opinion, but an attitude.
Min Zin
doaj  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Assessing the activity of ETC inhibitors against ELQ-300-resistant T. gondii parasites.

, 2023
(A-I) Dose-response curves depicting the percent proliferation of ELQ-300-resistant (ELQR, blue) T. gondii parasites, or the corresponding ELQ-300-sensitive parental strain (ELQS, black), in the presence of increasing concentrations of (A) ELQ-300, (B ...
Esther Rajendran (6321464), Rachel A. Leonard (5195411), Christina Spry (284689), F. Victor Makota (16625292), Laura Shuttleworth (16625295), Jenni A. Hayward (10063377), Ursula Wiedemann (16625298), Kevin J. Saliba (284698), Giel G. van Dooren (10063383), Alexander G. Maier (3955484), Daniela Cihalova (468074), Soraya M. Zwahlen (10063380)   +11 more
core   +1 more source

I Want It All, and I Want It Now: The Political Manipulation of Argentina’s Provincial High Courts I Want It All, and I Want It Now: La manipulación política de las Cortes Supremas provinciales en Argentina

Journal of Politics in Latin America, 2012
Provincial supreme courts are important players in local politics because justices can affect the interest of the ruling governors; however, no research has addressed the factors that affect judicial turnover in provincial high courts in new democracies.
Andrea Castagnola
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Malaysian General Elections of 2013: The Last Attempt at Secular-inclusive Nation-building?

Journal of Current Southeast Asian Affairs, 2013
This paper looks at the Malaysian General Election campaign of 2013, and focuses primarily on the 1Malaysia project that was foregrounded by the administration of Prime Minister Najib Razak.
Farish A. Noor
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source