Results 31 to 40 of about 755,225 (262)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Preferences on Redistribution in Fragmented Labor Markets in Latin America and the Caribbean
Journal of Politics in Latin America, 2015 This study investigates the extent to which labor market dualization polarizes preferences on redistribution between formal and informal sector workers in Latin America and the Caribbean.
Sarah Berens
doaj
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Book Review: Hoffstaedter, Gerhard, Modern Muslim Identities: ...
Journal of Current Southeast Asian Affairs, 2012 Book Review of the monograph: Hoffstaedter, Gerhard (2011), Modern Muslim Identities: Negotiating Religion and Ethnicity in Malaysia Copenhagen: NIAS Press (= NIAS Monographs # 119), ISBN 978-87-7694-081-2, 304 ...
Holger Warnk
doaj
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Journal of Politics in Latin America, 2012 The books under review all deal with the same fundamental phenomenon: mobilization against neoliberal policies by South American indigenous groups.
Kevin Funk
doaj
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
China–Myanmar Comprehensive Strategic Cooperative Partnership: A Regional Threat?
Journal of Current Southeast Asian Affairs, 2012 This paper analyses the China-Myanmar ‘comprehensive strategic cooperative partnership’ in the framework of China’s diplomacy in the post-Cold War era and concludes that the partnership has no ‘significant negative impact’ on regional relations.
Chenyang LI
doaj
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source