Results 61 to 70 of about 10,459,359 (387)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The European Union’s Myanmar Policy: Focused or Directionless?

Journal of Current Southeast Asian Affairs, 2015
What is the European Union (EU) trying to achieve in Myanmar? Is the EU speaking with one voice and acting collectively (and does it really matter)? Were the sanctions lifted too early?
Jörn Dosch, Jatswan S. Sidhu
doaj  

Molecular Cloud-scale Star Formation in NGC 300

, 2014
We present the results of a galaxy-wide study of molecular gas and star formation in a sample of 76 HII regions in the nearby spiral galaxy NGC 300. We have measured the molecular gas at 250 pc scales using pointed CO(J=2-1) observations with the APEX ...
Bouy, Herve, Faesi, Christopher M., Forbrich, Jan, Lada, Charles J., Menten, Karl   +4 more
core   +1 more source

Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer [PDF]

, 2015
Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the ...
A Perera, A Prats, A Rodriguez-Ulloa, A Siddiqui-Jain, AM Solares, B E Acevedo, C A Casacó, C M Valenzuela, CA Naranjo, D F Alonso, F Piazza, I Baladrón, I García, I Hernández, J A Ancízar, JA Siegel, JL Soriano-García, JS Duncan, KA Ahmad, L A Torres, L González, L Molina, M A Coca, M R Sarduy, M Solares, P A López-Saura, P Therasse, R Gómez, R Prudent, RE Carter, S E Perea-Rodríguez, S Tawfic, SE Perea, SE Perea, SE Perea, V Reyes, Y M González, Y M Martínez, Y Perera, Y Perera, Y Perera, Y Perera   +41 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

China’s Potential for Economic Coercion in the South China Sea Disputes: A Comparative Study of the Philippines and Vietnam

Journal of Current Southeast Asian Affairs, 2012
With tensions rising in the South China Sea, China’s use of its economic leverage over Southeast Asian countries has recently come into focus. With increasing economic and trade ties between China and Southeast Asia, the question being asked is whether ...
Madhu Sudan Ravindran
doaj  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Book Review: Jandl, Thomas, Vietnam in the Global Economy – The Dy-namics of Integration, Decentralization and Contested Politics

Journal of Current Southeast Asian Affairs, 2014
Book Review of the Monograph: Thomas Jandl (2013), Vietnam in the Global Economy – The Dynamics of Integration, Decentralization and Contested Politics.
Adam Fforde
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

New insulin glargine 300 U/ml compared with glargine 100 U/ml in insulin-naïve people with type 2 diabetes on oral glucose-lowering drugs: a randomized controlled trial (EDITION 3)

Diabetes, obesity and metabolism, 2015
To compare the efficacy and safety of new insulin glargine 300 U/ml (Gla‐300) with that of glargine 100 U/ml (Gla‐100) in insulin‐naïve people with type 2 diabetes using oral glucose‐lowering drugs.
G. Bolli, M. Riddle, R. Bergenstal, M. Ziemen, K. Sestakauskas, H. Goyeau, P. Home   +6 more
semanticscholar   +1 more source