Results 61 to 70 of about 9,598,974 (290)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
The Malaysian General Elections of 2013: The Last Attempt at Secular-inclusive Nation-building?
Journal of Current Southeast Asian Affairs, 2013 This paper looks at the Malaysian General Election campaign of 2013, and focuses primarily on the 1Malaysia project that was foregrounded by the administration of Prime Minister Najib Razak.
Farish A. Noor
doaj
The existence and asymptotic properties of a backfitting projection algorithm under weak conditions. [PDF]
We derive the asymptotic distribution of a new backfitting procedure for estimating the closest additive approximation to a nonparametric regression function.
Linton, Oliver, Mammen, E., Nielsen, J.
core +1 more source
On the optical counterpart of NGC300 X-1 and the global Wolf-Rayet content of NGC300
, 2007 (Conext:) Surveys of Wolf-Rayet (WR) populations in nearby galaxies provide tests of evolutionary models plus Type Ib/c supernova progenitors. This spectroscopic study complements the recent imaging survey of the spiral galaxy NGC 300 by Schild et al ...
A. M. T. Pollock +30 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Journal of Politics in Latin America, 2012 Does Latin America’s left turn matter in media politics? Has ideology any impact on governments’ practices and policies regarding media and journalistic institutions? This essay focuses on the existence of a specific kind of media activism on the part of
Philip Kitzberger
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Journal of Current Southeast Asian Affairs, 2016 This article assesses the knowledge of, attitudes towards, and aspirations for ASEAN among Thai university students, who are set to enter the ASEAN Community labour market and are among those most in touch with ASEAN issues.
Pinn Siraprapasiri +1 more
doaj
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Journal of Current Southeast Asian Affairs, 2014 This paper examines the rationale by which mainland Chinese firms choose their coalition partners in their Malaysian ventures. I explore how, under certain political economic conditions, such cross-border investment and corporate tie-ups can be shaped to
Guanie LIM
doaj