Results 21 to 30 of about 31,706 (176)

Aerosol Delivery of Palivizumab in a Neonatal Lamb Model of Respiratory Syncytial Virus Infection

Viruses, 2023
(1) Background: Palivizumab has been an approved preventative monoclonal antibody for respiratory syncytial virus (RSV) infection for over two decades. However, due to its high cost and requirement for multiple intramuscular injections, its use has been ...
Hasindu S. Edirisinghe, Anushi E. Rajapaksa, Simon G. Royce, Magdy Sourial, Robert J. Bischof, Jeremy Anderson, Gulcan Sarila, Cattram D. Nguyen, Kim Mulholland, Lien Anh Ha Do, Paul V. Licciardi   +10 more
doaj   +1 more source

Toblerone: detecting exon deletion events in cancer using RNA-seq [version 1; peer review: 2 approved]

F1000Research, 2023
Cancer is driven by mutations of the genome that can result in the activation of oncogenes or repression of tumour suppressor genes. In acute lymphoblastic leukemia (ALL) focal deletions in IKAROS family zinc finger 1 (IKZF1) result in the loss of zinc ...
Andrew Lonsdale, Paul Ekert, Hansen Kosasih, Alicia Oshlack, Andreas Halman, Lauren Brown   +5 more
doaj   +1 more source

Ex Vivo Restimulation of Human PBMC Expands a CD3+CD4-CD8-γδ+ T Cell Population That Can Confound the Evaluation of CD4 and CD8 T Cell Responses to Vaccination

Clinical and Developmental Immunology, 2013
The measurement of vaccine-induced humoral and CD4+ and CD8+ cellular immune responses represents an important correlate of vaccine efficacy. Accurate and reliable assays evaluating such responses are therefore critical during the clinical development ...
B. J. Sedgmen, L. Papalia, L. Wang, A. R. Dyson, H. A. McCallum, C. M. Simson, M. J. Pearse, E. Maraskovsky, D. Hung, P. P. Eomois, G. Hartel, M. J. Barnden, S. P. Rockman   +12 more
doaj   +1 more source

Australia’s Role in Pneumococcal and Human Papillomavirus Vaccine Evaluation in Asia-Pacific

Vaccines, 2021
Australian researchers have made substantial contributions to the field of vaccinology over many decades. Two examples of this contribution relate to pneumococcal vaccines and the human papillomavirus (HPV) vaccine, with a focus on improving access to ...
Zheng Quan Toh, Chau Quang, Joseph A. Tooma, Suzanne M. Garland, Kim Mulholland, Paul V. Licciardi   +5 more
doaj   +1 more source

Ankle Dorsiflexor Function after Gastrocsoleus Lengthening in Children with Cerebral Palsy: A Literature Review

Medicina, 2022
Background and Objectives: Ambulant children with cerebral palsy can demonstrate persistent “foot drop” after successful gastrocsoleus lengthening (GSL) surgery for equinus deformity.
Nicholas Sclavos, Norine Ma, Elyse Passmore, Pam Thomason, H. Kerr Graham, Erich Rutz   +5 more
doaj   +1 more source

Viral MLKL Homologs Subvert Necroptotic Cell Death by Sequestering Cellular RIPK3

Cell Reports, 2019
Summary: Necroptotic cell death has been implicated in many human pathologies and is thought to have evolved as an innate immunity mechanism. The pathway relies on two key effectors: the kinase receptor-interacting protein kinase 3 (RIPK3) and the ...
Emma J. Petrie, Jarrod J. Sandow, Wil I.L. Lehmann, Lung-Yu Liang, Diane Coursier, Samuel N. Young, Wilhelmus J.A. Kersten, Cheree Fitzgibbon, André L. Samson, Annette V. Jacobsen, Kym N. Lowes, Amanda E. Au, Hélène Jousset Sabroux, Najoua Lalaoui, Andrew I. Webb, Guillaume Lessene, Gerard Manning, Isabelle S. Lucet, James M. Murphy   +18 more
doaj   +1 more source

Olfactory Bulb Volume Reflects Olfactory Dysfunction and Network Organization: Insights From the Population‐Based Rhineland Study

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Olfactory dysfunction is common in aging and an early symptom of neurodegenerative diseases, but how structural (olfactory bulb [OB] volume) and functional (olfactory network [OFN] functional connectivity [FC]) brain features interact to shape odor identification ability remains unclear.
Weiyi Zeng, Konstantinos Melas, Santiago Estrada, N. Ahmad Aziz, Monique M. B. Breteler   +4 more
wiley   +1 more source

Mental Health Impacts of the COVID-19 Pandemic on Australian Children and Adolescents with a Medical Condition: Longitudinal Findings

COVID
In Melbourne, Australia, strict ‘lockdowns’ were implemented in 2020 to suppress COVID-19, significantly disrupting daily life. Young people (
Louise M. Crowe, Cathriona Clarke, Dan Geraghty, Ben Collins, Stephen Hearps, Remy Pugh, Nicola Kilpatrick, Emma Branson, Jonathan M. Payne, Kristina Haebich, Natalie McCloughan, Christopher Kintakas, Genevieve Charles, Misel Trajanovska, Ivy Hsieh, Penelope L. Hartmann, Sebastian King, Nicholas Anderson, Vicki Anderson   +18 more
doaj   +1 more source

The quantification and epistemology of medicines use and polypharmacy tested in an observational study

British Journal of Clinical Pharmacology, EarlyView.
Definitions of ‘medicines use’ and ‘polypharmacy’ may refer to all medicines, regular long‐term medicines or another subset. Valid definitions of medicines use should incorporate type of use (long term, short course and as needed [PRN]), changes in use (start, stop and dose change) and a description of temporal examination (cross‐sectional or ...
Lorna Pairman, Paul Chin, Matthew Doogue
wiley   +1 more source

Progress report on new epilepsy treatments: A summary of the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII). I. Treatments in preclinical and early clinical development

Epilepsia, EarlyView.
Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer, Cecilie Johannessen Landmark, Matthias J. Koepp, Emilio Perucca, Piero Perucca, Torbjörn Tomson, H. Steve White, Elaine Wirrell   +7 more
wiley   +1 more source