Results 1 to 10 of about 91,886 (192)

Structure of RNA polymerase bound to ribosomal 30S subunit

eLife, 2017
In bacteria, mRNA transcription and translation are coupled to coordinate optimal gene expression and maintain genome stability. Coupling is thought to involve direct interactions between RNA polymerase (RNAP) and the translational machinery.
Gabriel Demo, Aviram Rasouly, Nikita Vasilyev, Vladimir Svetlov, Anna B Loveland, Ruben Diaz-Avalos, Nikolaus Grigorieff, Evgeny Nudler, Andrei A Korostelev   +8 more
doaj   +2 more sources

Conformational Response of 30S-bound IF3 to A-Site Binders Streptomycin and Kanamycin

Antibiotics, 2016
Aminoglycoside antibiotics are widely used to treat infectious diseases. Among them, streptomycin and kanamycin (and derivatives) are of importance to battle multidrug-resistant (MDR) Mycobacterium tuberculosis.
Roberto Chulluncuy, Carlos Espiche, Jose Alberto Nakamoto, Attilio Fabbretti, Pohl Milón   +4 more
doaj   +2 more sources

The Cryo-EM structure of a complete 30S translation initiation complex from Escherichia coli. [PDF]

PLoS Biology, 2011
Formation of the 30S initiation complex (30S IC) is an important checkpoint in regulation of gene expression. The selection of mRNA, correct start codon, and the initiator fMet-tRNA(fMet) requires the presence of three initiation factors (IF1, IF2, IF3 ...
Patricia Julián, Pohl Milon, Xabier Agirrezabala, Gorka Lasso, David Gil, Marina V Rodnina, Mikel Valle   +6 more
doaj   +2 more sources

The translation inhibitors kasugamycin, edeine and GE81112 target distinct steps during 30S initiation complex formation. [PDF]

Nat Commun
During bacterial translation initiation, the 30S ribosomal subunit, initiation factors, and initiator tRNA define the reading frame of the mRNA. This process is inhibited by kasugamycin, edeine and GE81112, however, their mechanisms of action have not ...
Safdari HA, Morici M, Sanchez-Castro A, Dallapè A, Paternoga H, Giuliodori AM, Fabbretti A, Milón P, Wilson DN.   +8 more
europepmc   +2 more sources

Impact of Calcium Propionate Supplementation on the Lactation Curve and Milk Metabolomic Analysis on Rambouillet Ewes. [PDF]

Vet Sci
In lactating ewes, energy demand increases for milk production, reserve mobilizations, and body weight maintenance. For reconversion to energy, ruminants require ruminal propionate production because it is the most predominant substrate for ...
Pérez Segura LF, Lee-Rangel HA, Flores Ramirez R, García-López JC, Álvarez-Fuentes G, Vázquez Valladolid A, Hernández-García PA, Negrete Sanchez O, Rendon Huerta JA.   +8 more
europepmc   +2 more sources

Abstract P-31: Assembly of the Complex of the 30S Ribosomal Subunit and the Ribosome Maturation Factor P from Staphylococcus aureus for Structural Studies by Cryo-Electron Microscopy [PDF]

International Journal of Biomedicine, 2021
Background: Staphylococcus aureus (S. aureus) is one of the main human pathogens causing numerous nosocomial soft tissue infections and is among the best-known causes of bacterial infections.
Natalia Garaeva, Aydar Bikmullin, Evelina Klochkova, Shamil Validov, Marat Yusupov, Konstantin Usachev   +5 more
doaj   +1 more source

Abstract P-27: The 30S Ribosomal Subunit Assembly Factor Rbfa Plays a Key Role in the Formation of the Central Pseudoknot and in the Correct Docking of Helix 44 of the Decoding Center [PDF]

International Journal of Biomedicine, 2021
Background: Ribosome biogenesis is a complicated multi-stage process. In the cell, 30S ribosomal subunit assembly is fast and efficient, proceeding with the help of numerous assembly protein factors.
Elena M. Maksimova, Alexey P. Korepanov, Olesya V. Kravchenko, Timur N. Baymukhametov, Alexander G. Myasnikov, Konstantin S. Vassilenko, Zhanna A. Afonina, Elena A. Stolboushkina   +7 more
doaj   +1 more source

Abstract P-21: The Investigation of S.aureus Ribosome-Binding Factor A Localization on the 30S Ribosomal Subunit by Cryo-Electron Microscopy [PDF]

International Journal of Biomedicine, 2021
Background: Ribosome biogenesis is a complex process of ribosomal RNA and protein binding. Bacterial ribosome maturation and components involved in it are especially interesting, because they are widespread targets for antibiotics.
Aydar G. Bikmullin, Artem Stetsenko, Alexander Golubev, Liliia Nurullina, Iskander Khusainov, Evelina Klochkova, Natalia Garaeva, Konstantin Usachev   +7 more
doaj   +1 more source

Wheat straw and alfalfa hay alone or combined in a high-concentrate diet alters microbial-host interaction in the rumen of lambs. [PDF]

Anim Nutr
The inclusion of various forages in a normal forage-to-concentrate ratio has widely been reported to reveal the changes that occur in the foregut tissues.
Gebeyew K, Mi H, Du R, Gao M, Diba D, Tang S, He Z, Tan Z.   +7 more
europepmc   +2 more sources

RbfA Is Involved in Two Important Stages of 30S Subunit Assembly: Formation of the Central Pseudoknot and Docking of Helix 44 to the Decoding Center

International Journal of Molecular Sciences, 2021
Ribosome biogenesis is a highly coordinated and complex process that requires numerous assembly factors that ensure prompt and flawless maturation of ribosomal subunits.
E. Maksimova, A. Korepanov, O. Kravchenko, T. Baymukhametov, A. Myasnikov, K. Vassilenko, Z. Afonina, E. Stolboushkina   +7 more
semanticscholar   +1 more source