Single‐cell insights into the role of T cells in B‐cell malignancies
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
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Extensile exposure applied to limb surgery. By Arnold K. Henry, M.B. (Dubl.), M.Ch. (Hon., Cairo), F.R.C.S.I., Emeritus Professor of Clinical Surgery in the University of Egypt. 9 3/4 × 6 3/4. Pp. 180 + viii, with 127 illustrations. 1945. Edinburgh: E. & S. Livingstone. 30s. net [PDF]
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Background and Objectives: Our objectives were to examine the association between balance confidence, functional mobility measures, and the presence of disability in older adults in Saudi Arabia and to identify the optimal cutoff scores for these ...
Norah A. Alhwoaimel+4 more
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Writers Meridel Le Sueur and Tillie Olsen span two generations of radical women, those affiliated with the Old Left and those who came of age with the New Left and the most recent women's movement. One of the salient features of the 1930s was the failure
Constance Coiner
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The Evolution of Medical Education in the Nineteenth Century. Charles NewmanM.D., F. R. C. P., Dean of the Postgraduate Medical School of London. London: Oxford University Press, 1957; PP. X+340. 30S. [PDF]
J. F. Delafresnaye
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In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi+5 more
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Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää+2 more
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Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia+17 more
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Birds of the Atlantic Islands, Volume III: A History of the Birds of the Azores, by David Armitage Bannerman and W. Mary Bannerman Oliver ' Boyd, 84s. - Ireland's Birds, by Robert F. Ruttledge Witherby, 30s. [PDF]
Richard Fitter
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