Results 111 to 120 of about 5,138,121 (288)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Facial Similarity Measure for Recognizing Monozygotic Twins Utilizing 3D Facial Landmarks, Efficient Geodesic Distance Computation, and Machine Learning Algorithms

IEEE Access
Compared with 2D face recognition systems, 3D facial recognition has been a popular area of study in academia and industry because of its ability to detect human faces in an unconstrained environment more efficiently.
Gangothri Sanil, Krishna Prakasha, Srikanth Prabhu, Vinod C. Nayak   +3 more
doaj   +1 more source

Protocol for Systematic Literature Review of Face Recognition in Uncontrolled Environment

EAI Endorsed Transactions on Scalable Information Systems, 2018
One of the major challenges encountered by current face recognition techniques lies in the difficulties of handling varying poses, i.e., recognition of faces in arbitrary in-depth rotations. The face image differences caused by rotations are often larger
Faizan Ullah, Sabir Shah, Dilawar Shah, Abdul Salam, Shujaat Ali   +4 more
doaj   +1 more source

Occlusions in Face Recognition: a 3D Approach

, 2009
The real challenge in face detection and recognition technologies is the ability to handle all those scenarios where subjects are non-cooperative and the acquisition phase is unconstrained. In the last few years a great deal of effort has been spent to improve the performances where cooperative subjects are acquired in controlled conditions.
SCHETTINI, RAIMONDO, CUSANO, CLAUDIO, COLOMBO, ALESSANDRO   +2 more
openaire   +4 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Region-wise landmarks-based feature extraction employing SIFT, SURF, and ORB feature descriptors to recognize Monozygotic twins from 2D/3D Facial Images [version 2; peer review: 2 approved]

F1000Research
Background In computer vision and image processing, face recognition is increasingly popular field of research that identifies similar faces in a picture and assigns a suitable label.
Srikanth Prabhu, Vinod Nayak, Aparna Jayakala, Krishna Prakasha K, Gangothri Sanil   +4 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

3D Morphable Model Construction for Robust Ear and Face Recognition

Recent work suggests that the human ear varies significantly between different subjects and can be used for identification. In principle, therefore, using ears in addition to the face within a recognition system could improve accuracy and robustness ...
Nixon, Mark, Bustard, John
core   +1 more source

Adaptive face modelling for reconstructing 3D face shapes from single 2D images

IET Computer Vision, 2014
Example‐based statistical face models using principle component analysis (PCA) have been widely deployed for three‐dimensional (3D) face reconstruction and face recognition.
Ashraf Maghari, Ibrahim Venkat, Iman Yi Liao, Bahari Belaton   +3 more
doaj   +1 more source