Results 41 to 50 of about 74,601 (262)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Feed-Forward 3D Scene Modeling: A Problem-Driven Perspective

CoRR
67 pages, 395 references. Project page: https://ff3d-survey.github.io. Code: https://github.com/ziplab/Awesome-Feed-Forward-3D.
Weijie Wang, Qihang Cao, Sensen Gao, Donny Y. Chen, Haofei Xu, Wenjing Bian, Songyou Peng, Tat-Jen Cham, Chuanxia Zheng, Andreas Geiger 0001, Jianfei Cai 0001, Jia-Wang Bian, Bohan Zhuang   +12 more
openaire   +3 more sources

Quantitative prediction of sand bodies in a sparsely explored zone of the Tarim basin: A case study of the aketao area

Frontiers in Earth Science, 2023
Thin sandstone reservoirs of the fan delta front sub-facies occur in the early Neogene (Miocene) series of the Aketao (Akto) structural belt within the Kunlun piedmont zone of the Tarim Basin.
Shi Xiaoqian, Qu Yongqiang, Zhou Junfeng, Liu Wenhao, Liu Wenhao, Guo Juanjuan, Xie Junfa   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Finite-element forward modeling of transient EM in mines under metal interference

Meitan xuebao
Metal interference has always been one of the key factors affecting the reliability of transient electromagnetic (TEM) data in mines. Not only does it cause misjudgment in data interpretation, but it also can lead to ineffective signal.
Jiao ZHU, Zhihai JIANG, Changchun YIN, Changkai QIU, Maofei LI, Zhaofeng GAO   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Investigating surface-borehole transient electromagnetic responses from veined orebodies considering induced polarization effects

Meitian dizhi yu kantan
ObjectiveThe observational data derived using the surface-borehole transient electromagnetic (TEM) method tend to feature complex curve morphologies, a problem posing significant challenges to data processing and interpretation.
Jianhui LI, Yao WANG, Wenchuang WANG, Shaojian XIE, Siwei ZHU   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source