Results 51 to 60 of about 74,601 (262)

Studies of three dimensional stagged-grid finite difference for Z-axis tipper electromagnetic numerical simulation

Frontiers in Earth Science
ZTEM (Z-Axis Tipper Electromagnetic System) is a frequency-domain airborne electromagnetic exploration method that utilizes natural field sources. This method is highly efficient and capable of probing great depths, making it widely applicable in the ...
Yu Wang, Junhao Qu, Tingting Chen, Shaohui Zhou, Yajun Li   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Application of Realistic 3D Model in Building Prefabricated Nanomaterial Structure

International Journal of Analytical Chemistry, 2022
In order to solve the problem of 3D modeling in building assembly, an application of a 3D model based on the real scene in the building assembly structure is proposed.
Sihui Li
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

3D Gravity Modeling of Complex Salt Features in the Southern Gulf of Mexico

International Journal of Geophysics, 2016
We present a three-dimensional (3D) gravity modeling and inversion approach and its application to complex geological settings characterized by several allochthonous salt bodies embedded in terrigenous sediments.
Mauricio Nava-Flores, Carlos Ortiz-Aleman, Mauricio G. Orozco-del-Castillo, Jaime Urrutia-Fucugauchi, Alejandro Rodriguez-Castellanos, Carlos Couder-Castañeda, Alfredo Trujillo-Alcantara   +6 more
doaj   +1 more source

Similarity measure of sedimentary successions and its application in inverse stratigraphic modeling

Petroleum Science, 2017
This paper presents a unique and formal method of quantifying the similarity or distance between sedimentary facies successions from measured sections in outcrop or drilled wells and demonstrates its first application in inverse stratigraphic modeling. A
Taizhong Duan
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Divergence correction for three-dimensional magnetotelluric forward modelling with arbitrary electrical anisotropy

Frontiers in Earth Science
This paper presents an enhanced framework for three-dimensional (3D) magnetotelluric (MT) forward modeling that incorporates a current density divergence correction procedure for arbitrary anisotropic conditions. The method accelerates the convergence of
Guo Yu, Jing Han
doaj   +1 more source

Taming Feed-forward Reconstruction Models as Latent Encoders for 3D Generative Models

CoRR
Recent AI-based 3D content creation has largely evolved along two paths: feed-forward image-to-3D reconstruction approaches and 3D generative models trained with 2D or 3D supervision. In this work, we show that existing feed-forward reconstruction methods can serve as effective latent encoders for training 3D generative models, thereby bridging these ...
Suttisak Wizadwongsa, Jinfan Zhou, Edward Li, Jeong Joon Park   +3 more
openaire   +2 more sources