Results 151 to 160 of about 2,985,578 (313)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Editorial: 3D Modelling of Mammalian Embryos and Organs. [PDF]

Front Cell Dev Biol, 2021
Garagna S, Cebral E, Aréchaga J, Zuccotti M.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

3D Deep Learning Course

The course includes the full framework for coming up with AI processing workflows, understanding why and how 3D can extend 2D approaches, developing and testing 3D Deep Learning Models, getting quickly working models on various OS, building your own ...
Poux, Florent
core   +1 more source

3D Modelling of Mass Transfer into Bio-Composite. [PDF]

Polymers (Basel), 2021
Kabbej M, Guillard V, Angellier-Coussy H, Wolf C, Gontard N, Gaucel S.   +5 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

VisualSFM

, 2020
"VisualSFM is a GUI application for 3D reconstruction using structure from motion (SFM)…
Consortium 3D SHS Team
core  

Can 3D imaging modeling recognize functional tissue and predict liver failure? A retrospective study based on 3D modelling of the major hepatectomies after hepatic modulation. [PDF]

BMC Surg, 2023
Vicente E, Quijano Y, Duran H, Diaz E, Fabra I, Malave L, Ruiz P, Pizzuti G, Naldini C, De Nobili G, Caruso R, Ferri V.   +11 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

PRUSA I3 MK3S

, 2020
" 'Original Prusa i3 MK3S succède à l'imprimante 3D Original Prusa i3 MK2 ...
Consortium 3D SHS Team
core