Results 131 to 140 of about 760,415 (358)
Content: report on the choice of the 3D representation and on the 3D mapping activities. A focus of the performance assessment will be on on accuracy, reliability, and completeness of the reconstructed 3D structure both in terms of usable result for human operators as well as usage in the robotic navigation tasks.
Sander Münster +12 more
openaire +3 more sources
Key aspects in 3D fatigue crack closure numerical modelling [PDF]
, 2018 Since long time, fatigue crack closure has been studied by means of finite element models. Initially by bi-dimensional models and recently, due to the higher computational capabilities, the use of three-dimensional models has been extended, providing a
Camas, Daniel +2 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Internal geometry of structurally stitched NCF preforms [PDF]
, 2007 Internal geometry of a textile reinforcement is an important factor of the reinforcement performance during the composite manufacturing and service life.
Koissin, Vitaly +2 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Toward a 3D in vitro model based on decellularized thymus to maintain adult thymic ephitelial cells functionality [PDF]
, 2014 Valentina Strusi
openalex +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Distributed earth model/orbiter simulation [PDF]
Distributed Earth Model/Orbiter Simulation (DEMOS) is a network based application developed for the UNIX environment that visually monitors or simulates the Earth and any number of orbiting vehicles. Its purpose is to provide Mission Control Center (MCC)
Geisler, Erik +2 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source