Results 121 to 130 of about 140,547 (317)

Construction of 3D models of the Cracow Fortress Powder Magazine and determination of their accuracy using photogrammetric and terrestrial scanning methods

Reports on Geodesy and Geoinformatics
This study presents a comparative analysis of two three-dimensional reconstruction models of Powder Magazine no. 2 of the 19h-century Cracow Fortress, developed using terrestrial laser scanning (TLS) and close-range digital photogrammetry to assess the ...
Malec Agnieszka, Piech Izabela
doaj   +1 more source

Developing an Organisational Framework for Sustaining Virtual City Models [PDF]

This research thesis presents an organisational framework for the management of virtual cities for hosts to adopt when seeking to produce and maintain a virtual city for use as a tool for urban planning related activities.
Podevyn, Martin
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

The role of virtual reality and 3D modelling in built environment education [PDF]

, 2007
This study builds upon previous research on the integration of Virtual Reality (VR) within the built environment curriculum and aims to investigate the role of Virtual Reality and three-dimensional (3D) computer modelling on learning and teaching in a ...
Horne, Margaret, Thompson, Emine Mine, E. Thompson, M. Horne   +3 more
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

3D modelling for multipurpose cadastre [PDF]

, 2012
Three-dimensional (3D) modelling of cadastral objects (such as legal spaces around buildings, around utility networks and other spaces) is one of the important aspects for a multipurpose cadastre (MPC).
Hua, T.C. (author), Abduhl Rahman, A., Hassan, M.I. (author), Duncan, E.E. (author), Duncan, Edward Eric (author), Hassan, Muhammad Imzan (author), Sharkawi, K.H. (author), Sharkawi, Khairul Hafiz (author), Hua, T.C., Van Oosterom, P.J.M. (author), Abduhl Rahman, A. (author), Duncan, E.E., Azri, N., van Oosterom, Peter (author), Van Oosterom, P.J.M., Azri, N. (author), Sharkawi, K.H., Hassan, M.I., Abdul Rahman, Alias (author), Chee Hua, Teng (author), Azri, Norsuhaibah (author)   +20 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Conceptual Modelling in 3D Virtual Worlds for Process Communication [PDF]

, 2010
Traditionally, conceptual modelling of business processes involves the use of visual grammars for the representation of, amongst other things, activities, choices and events.
Brown , Ross
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source