Results 81 to 90 of about 3,277,616 (304)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
L’archivage pérenne des modèles numériques 3D pour les SHS
, 2020 Ce document est la formalisation d’une étape de la réflexion consacrée à l'archivage des données 3D mené au sein du consortium 3D SHS en collaboration avec Huma-Num et le CINES.
Consortium 3D SHS Team
core
[Offres]DEV Soft Images 3D et datas
, 2021 La mission consiste à créer des outils logiciels permettant d'intégrer, d'automatiser et d'optimiser la chaîne de traitement et de visualisation de l'imagerie numérique 3D et RTI (reflectance transformation imaging) à destination des experts et de la ...
Consortium 3D SHS Team
core
‘Figures in 3D’: Digital Perspectives on Cretan Bronze Age Figurines
Open Archaeology, 2018 The largest corpus of clay figurines from the Cretan Bronze Age comes from ritual mountain sites known as peak sanctuaries. In this paper, we explore how the ‛Figures in 3D’ project contributes to our understanding of these figurines, aiding in the study
Morris Christine +2 more
doaj +1 more source
Extrusion-based Fused Deposition Modeling is widely used for varieties of material. Ultra High Molecular Weight Polyethylene (UHMWPE) has extremely long chains resulting in a very tough material, with high impact strength. If UHMWPE can be made in freeform, lots of application can take the advantage of this novel material.
Harnoor Singh, Kaiyue Deng, Zipeng Guo
openaire +1 more source
Optics Express, 2018 3D meso-scale structures that can reach up to centimeters in overall size but retain micro- or nano-features, proved to be promising in various science fields ranging from micro-mechanical metamaterials to photonics and bio-medical scaffolds. In this work we present synchronization of the linear and galvano scanners for efficient femtosecond 3D optical
Linas Jonušauskas +5 more
openaire +4 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Vocabulaire 3D - Lexique pour les Sciences Humaines et Sociales
, 2020 "Ce document est le résultat d’un effort continu pour permettre aux acteurs des SHS et ceux de la 3D d’interagir autour d’un vocabulaire commun. Ce lexique a pour but d’accompagner les différents livrables du consortium 3D.
Consortium 3D SHS Team
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source