Results 81 to 90 of about 104,995 (269)

Consistent and reproducible cultures of large-scale 3D mammary epithelial structures using an accessible bioprinting platform

Breast Cancer Research, 2018
Background Standard three-dimensional (3D) in vitro culture techniques, such as those used for mammary epithelial cells, rely on random distribution of cells within hydrogels.
John A. Reid, Peter A. Mollica, Robert D. Bruno, Patrick C. Sachs   +3 more
doaj   +1 more source

DEVELOPMENT OF SOFTWARE FOR IDENTIFICATION OF FILAMENTS USED IN 3D PRINTING TECHNOLOGY [PDF]

Applied Computer Science, 2019
The aim of the work was to develop a computer program that allows iden-tification of polymer materials that are used in 3D printing technology. The computer program was made using the algorithm that concerns the method of thermal polymer degradation ...
Sylwester KORGA, Marcin BARSZCZ, Krzysztof DZIEDZIC   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The use of 3D additive manufacturing technology in autogenous dental transplantation

3D Printing in Medicine, 2020
Background In medicine and dentistry, 3D technology allows the virtual planning and printing of surgical replicas of anatomical structures that can facilitate certain transplant procedures.
Pau Cahuana-Bartra, Abel Cahuana-Cárdenas, Lluís Brunet-Llobet, Marta Ayats-Soler, Jaume Miranda-Rius, Alejandro Rivera-Baró   +5 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Planet formation: The case for large efforts on the computational side [PDF]

, 2019
Modern astronomy has finally been able to observe protoplanetary disks in reasonable resolution and detail, unveiling the processes happening during planet formation. These observed processes are understood under the framework of disk-planet interaction,
Alarcon, Felipe, Apai, Daniel, Bayo, Amelia, Bergin, Edwin, Bitsch, Bertram, Carrera, Daniel, Casassus, Simon, Cleeves, Ilse, Cooray, Asantha, Cuello, Nicolás, Currie, Thayne, Dong, Ruobing, Du, Fujun, Golabek, Gregor, Gressel, Oliver, Gurwell, Mark, Gáspár, Andras, Hall, Cassandra, Haworth, Thomas, Ilee, John, Isella, Andrea, Izidoro, Andre, Jang-Condell, Hannah, Jorgensen, Jes, Kama, Mihkel, Kim, Jinyoung Serena, Klahr, Hubert, Krijt, Sebastiaan, Leigh, Nathan, Leisawitz, David, Lichtenberg, Tim, Lodato, Giuseppe, Lyra, Wladimir, Mac Low, Mordecai-Mark, Maddison, Sarah, Mamatsashvili, George, Mawet, Dimitri, McNally, Colin, Meixner, Margaret, Monnier, John, Pascucci, Ilaria, Picogna, Giovanni, Pontoppidan, Klaus, Pérez, Sebastián, Ricci, Luca, Sengupta, Debanjan, Shang, Hsien, Simon, Jake, Stamatellos, Dimitris, Szulágyi, Judit, Teague, Richard, Turner, Neal, Umurhan, Orkan, van der Marel, Nienke, White, Jacob, Wilner, David, Wootten, Al   +56 more
core   +1 more source