Results 91 to 100 of about 104,995 (269)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

‘Figures in 3D’: Digital Perspectives on Cretan Bronze Age Figurines

open access: yesOpen Archaeology, 2018
The largest corpus of clay figurines from the Cretan Bronze Age comes from ritual mountain sites known as peak sanctuaries. In this paper, we explore how the ‛Figures in 3D’ project contributes to our understanding of these figurines, aiding in the study
Morris Christine   +2 more
doaj   +1 more source

The Proficiency of Experts [PDF]

open access: yes, 2018
Expert evidence plays a crucial role in civil and criminal litigation. Changes in the rules concerning expert admissibility, following the Supreme Court\u27s Daubert ruling, strengthened judicial review of the reliability and the validity of an expert ...
Garrett, Brandon L., Mitchell, Gregory
core   +2 more sources

The Effect of the Radial Pressure Gradient in Protoplanetary Disks on Planetesimal Formation

open access: yes, 2010
The streaming instability (SI) provides a promising mechanism for planetesimal formation because of its ability to concentrate solids into dense clumps.
Bai   +23 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Effects of Rotation on Stochasticity of Gravitational Waves in Nonlinear Phase of Core-Collapse Supernovae

open access: yes, 2011
By performing three-dimensional (3D) simulations that demonstrate the neutrino-driven core-collapse supernovae aided by the standing accretion shock instability (SASI), we study how the spiral modes of the SASI can have impacts on the properties of the ...
Ando   +45 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

A linear distribution of orbits in compact planetary systems?

open access: yes, 2013
We report a linear ordering of orbits in a sample of multiple extrasolar planetary systems with super-Earth planets. We selected 20 cases, mostly discovered by the Kepler mission, hosting at least four planets within \sim 0.5 au.
Gozdziewski, Krzysztof   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Automated 3D Printing in Libraries

open access: yesCode4Lib Journal, 2022
This article highlights the creation of an automated 3D printed system created at a health sciences library at a large research university. As COVID-19 limited in-person interaction with 3D printers, a group of library staff came together to code a form ...
Brandon Patterson   +2 more
doaj  

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