Results 41 to 50 of about 272,957 (266)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Materials & Design, 2020 Spasticity is an important factor limiting independency and activity of daily living for post-stroke patients. Our aim was to develop a cost effective, customized, lightweight active orthosis, which is convenient for daily home use.The study describes ...
Luca Toth +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Research on Application of 3D Simulation Technology in Industrial Product Design Technology
Advances in Multimedia, 2022 In order to study the driving effect of industrial product design, a method based on the application of 3D simulation technology in industrial product design technology was proposed.
Chenhan Huang, Daijiao Shi
doaj +1 more source
Dynamic simulation of 3D-printed foods
Future Foods, 2023 Simulation environments for 3D-printed structures are crucial to assess failure modes prior to printing. Multi-ingredient additive manufacturing (AM) of food is particularly susceptible to failure due to differences in ingredient viscoelasticity. Current simulation software handles objects in their final fabricated form.
Shir Goldfinger +2 more
openaire +3 more sources
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Nihon Kikai Gakkai ronbunshu, 2016 Nanofluids are suspension dispersed nano-scale particles in a base fluid. In this study, natural convective heat transfer characteristics of Al2O3-water nanofluids in a vertical cylindrical container heated from below and cooled from above are ...
Masato AKAMATSU +4 more
doaj +1 more source
A 3D simulator for intelligent environment experiments [PDF]
2017 IEEE SmartWorld, Ubiquitous Intelligence & Computing, Advanced & Trusted Computed, Scalable Computing & Communications, Cloud & Big Data Computing, Internet of People and Smart City Innovation (SmartWorld/SCALCOM/UIC/ATC/CBDCom/IOP/SCI), 2017 The advances in sensor networks, electronics and ambient intelligence make creation of intelligent environments (IEs) possible. However, on account of economic and logistic issues the implementation of physical IEs is difficult in research domain. That makes it harder for researchers to experiment new approaches in IE domain.
Yannick Francillette +3 more
openaire +2 more sources