Results 41 to 50 of about 346,563 (267)
3D Numerical Investigation of Heat Transfer Performance in Liquid-liquid Taylor Flow [PDF]
Journal of Applied and Computational MechanicsWith recent advances in semiconductor technology, conventional cooling methods and standard coolants are no longer adequate to manage electronic chips’ enormous heat generation.
MOHAMMED SAID +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Practitioners' perception of the impacts of virtual reality on discrete-event simulation [PDF]
, 2005 This paper presents the results from surveying simulation practitioners from industry and academics who have used 2D or 3D software applications for Discrete-Event Simulation (DES) projects.
Akpan, J I, Brooks, R J
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
3D simulation using the lattice Boltzmann method of heat transfer in a local with different door positions [PDF]
EPJ Web of ConferencesThis study numerically examines three-dimensional natural convection in a bottom-heated, closed cubic cavity using the lattice Boltzmann method. The computational approach relies on a D3Q15 lattice scheme coupled with a single-time relaxation (SRT ...
Choukrallah Karim +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Experimental investigation of the impacts of virtual reality on discrete-event simulation [PDF]
, 2005 This paper presents the results of experimental studies that were undertaken to test the impacts of Virtual Reality (VR) on Discrete-Event Simulation (DES). The experiments focused on spotting errors in the DES model.
Akpan, J I, Brooks, R J
core
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Materials & Design, 2020 Spasticity is an important factor limiting independency and activity of daily living for post-stroke patients. Our aim was to develop a cost effective, customized, lightweight active orthosis, which is convenient for daily home use.The study describes ...
Luca Toth +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source