Results 41 to 50 of about 4,975,139 (352)

3D Numerical Investigation of Heat Transfer Performance in Liquid-liquid Taylor Flow [PDF]

Journal of Applied and Computational Mechanics
With recent advances in semiconductor technology, conventional cooling methods and standard coolants are no longer adequate to manage electronic chips’ enormous heat generation.
MOHAMMED SAID, NOURA NAIT BOUDA, SOUAD HARMAND   +2 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Three-Dimensional Simulation Model for Synergistically Simulating Urban Horizontal Expansion and Vertical Growth

Remote Sensing, 2022
Urban expansion studies have focused on two-dimensional planar dimensions, ignoring the impact of building height growth changes in the vertical direction on the urban three-dimensional (3D) spatial expansion.
Linfeng Zhao, Xiaoping Liu, Xiaocong Xu, Cuiming Liu, Keyun Chen   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

3D simulation using the lattice Boltzmann method of heat transfer in a local with different door positions [PDF]

EPJ Web of Conferences
This study numerically examines three-dimensional natural convection in a bottom-heated, closed cubic cavity using the lattice Boltzmann method. The computational approach relies on a D3Q15 lattice scheme coupled with a single-time relaxation (SRT ...
Choukrallah Karim, Abouricha Noureddine, Achak Mounia, El Alami Mustapha   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

3D HOP

, 2020
" 3DHOP (3D Heritage Online Presenter) is an open-source software package for the creation of interactive Web presentations of high-resolution 3D models, oriented to the Cultural Heritage field....
Consortium 3D SHS Team
core  

3D simulation of fully formed knitted dress based on dynamic postures

AUTEX Research Journal
To overcome the limitations of current knitting CAD systems in loop-level simulation of the dynamic postures of three-dimensional knitted garments, this study proposes a 3D simulation method integrating parametric loop modelling and a space mapping ...
Cheng Bilian, Huang Chaowei, Li Jie, Fu Shasha, Zhang Yi, Wu Puyu, Tian Bingying, Cui Yongbin   +7 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Conservatoire des Données 3D SHS

, 2020
” Le Conservatoire National des Données 3D SHS est un environnement de sauvegarde sécurisé pour les données 3D, soutenu par Huma-Num.. …
Consortium 3D SHS Team
core