Results 31 to 40 of about 607 (102)

Synthetic nanoprobes for biological hydrogen sulfide detection and imaging

VIEW, Volume 3, Issue 4, July 2022., 2022
Current advances of nanomaterial‐based probes for in vitro and in vivo H2S sensing and imaging. The existing challenges in developing H2S nanoprobes and aspects that affect probe's performance are also discussed. Abstract Hydrogen sulfide (H2S) is a gaseous molecule involved in multiple biological and physiological processes, including various diseases
Yingzhu Zhou, Federico Mazur, Qingqing Fan, Rona Chandrawati   +3 more
wiley   +1 more source

Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H2S Biogenesis and the Effects Are Transmitted Transgenerationally

Frontiers in Immunology, 2020
Rationale: Gestational cigarette smoke (CS) impairs lung angiogenesis and alveolarization, promoting transgenerational development of asthma and bronchopulmonary dysplasia (BPD).
Shashi P. Singh, Dinesh Devadoss, Marko Manevski, Aryaz Sheybani, Teodora Ivanciuc, Vernat Exil, Hemant Agarwal, Veena Raizada, Roberto P. Garofalo, Hitendra S. Chand, Mohan L. Sopori   +10 more
doaj   +1 more source

Hydrogen sulfide donor protects against mechanical ventilation‐induced atrophy and contractile dysfunction in the rat diaphragm

Clinical and Translational Science, Volume 14, Issue 6, Page 2139-2145, November 2021., 2021
Abstract Mechanical ventilation (MV) is a clinical tool providing adequate alveolar ventilation in patients that require respiratory support. Although a life‐saving intervention for critically ill patients, prolonged MV results in the rapid development of inspiratory muscle weakness due to both diaphragmatic atrophy and contractile dysfunction ...
Noriko Ichinoseki‐Sekine, Ashley J. Smuder, Aaron B. Morton, James M. Hinkley, Andres Mor Huertas, Scott K. Powers   +5 more
wiley   +1 more source

High‐intensity exercise in hypoxia improves endothelial function via increased nitric oxide bioavailability in C57BL/6 mice

Acta Physiologica, Volume 233, Issue 2, October 2021., 2021
Abstract Aim The optimal exercise intensity to improve endothelial function remains unclear, as well as whether the addition of hypoxia could potentiate this function. Therefore, the aim of this study was to compare the effects of different exercise intensities in normoxia and hypoxia on vascular reactivity and nitric oxide (NO) bioavailability in mice.
Jessica Lavier, Manon Beaumann, Steeve Menétrey, Karima Bouzourène, Nathalie Rosenblatt‐Velin, Vincent Pialoux, Lucia Mazzolai, Anne‐Christine Peyter, Maxime Pellegrin, Grégoire P. Millet   +9 more
wiley   +1 more source

Hydrogen sulphide reduces hyperhomocysteinaemia‐induced endothelial ER stress by sulfhydrating protein disulphide isomerase to attenuate atherosclerosis

Journal of Cellular and Molecular Medicine, Volume 25, Issue 7, Page 3437-3448, April 2021., 2021
Abstract Hyperhomocysteinaemia (HHcy)‐impaired endothelial dysfunction including endoplasmic reticulum (ER) stress plays a crucial role in atherogenesis. Hydrogen sulphide (H2S), a metabolic production of Hcy and gasotransmitter, exhibits preventing cardiovascular damages induced by HHcy by reducing ER stress, but the underlying mechanism is unclear ...
Shan Jiang, Wenjing Xu, Zhenzhen Chen, Changting Cui, Xiaofang Fan, Jun Cai, Yongsheng Gong, Bin Geng   +7 more
wiley   +1 more source

Production of hydrogen sulfide from D-cysteine and its therapeutic potential

Frontiers in Endocrinology, 2013
Accumulating evidence shows that H2S has physiological functions in various tissues and organs. It includes regulation of neuronal activity, vascular tension, a release of insulin, and protection of the heart, kidney and brain from ischemic insult. H2S
Norihiro eShibuya, Hideo eKimura
doaj   +1 more source

Increased endogenous H₂S generation by CBS, CSE, and 3MST gene therapy improves ex vivo renovascular relaxation in hyperhomocysteinemia

American Journal of Physiology-Cell Physiology, 2012
Hydrogen sulfide (H2S) has recently been identified as a regulator of various physiological events, including vasodilation, angiogenesis, antiapoptotic, and cellular signaling. Endogenously, H2S is produced as a metabolite of homocysteine (Hcy) by cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), and 3-mercaptopyruvate sulfurtransferase ...
Utpal, Sen, Pushpakumar B, Sathnur, Sourav, Kundu, Srikanth, Givvimani, Denise M, Coley, Paras K, Mishra, Natia, Qipshidze, Neetu, Tyagi, Naira, Metreveli, Suresh C, Tyagi   +9 more
openaire   +3 more sources

Corrigendum to “A Hypothesis: Hydrogen Sulfide Might Be Neuroprotective against Subarachnoid Hemorrhage Induced Brain Injury”

The Scientific World Journal, Volume 2020, Issue 1, 2020., 2020
Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia‐reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti ...
Yong-Peng Yu, Xiang-Lin Chi, Li-Jun Liu
wiley   +1 more source

Oxidative, Reductive, and Nitrosative Stress Effects on Epigenetics and on Posttranslational Modification of Enzymes in Cardiometabolic Diseases

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Oxidative (OS), reductive (RS), and nitrosative (NSS) stresses produce carbonylation, glycation, glutathionylation, sulfhydration, nitration, and nitrosylation reactions. OS, RS, and NSS are interrelated since RS results from an overactivation of antioxidant systems and NSS is the result of the overactivation of the oxidation of nitric oxide (NO). Here,
I. Pérez-Torres, M. E. Soto, V. Castrejón-Tellez, M. E. Rubio-Ruiz, L. Manzano Pech, V. Guarner-Lans, Oluyomi Stephen Adeyemi   +6 more
wiley   +1 more source

Hydrogen Sulfide Protects Retinal Pigment Epithelial Cells from Oxidative Stress‐Induced Apoptosis and Affects Autophagy

Oxidative Medicine and Cellular Longevity, Volume 2020, Issue 1, 2020., 2020
Age‐related macular degeneration (AMD) is a major cause of visual impairment and blindness among the elderly. AMD is characterized by retinal pigment epithelial (RPE) cell dysfunction. However, the pathogenesis of AMD is still unclear, and there is currently no effective treatment. Accumulated evidence indicates that oxidative stress and autophagy play
Liming Hu, Jia Guo, Li Zhou, Sen Zhu, Chunming Wang, Jiawei Liu, Shanshan Hu, Mulin Yang, Changjun Lin, Ratanesh K. Seth   +9 more
wiley   +1 more source