3Rs Principle and Legislative Decrees to Achieve High Standard of Animal Research [PDF]
Animals, 2023 Animal experimentation is a vast ecosystem that tries to make different issues such as legislative, ethical and scientific coexist. Research in animal experimentation has made many strides thanks to the 3Rs principle and the attached legislative decrees,
Paolo Verderio +5 more
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The 3Rs Principle in Animal Experimentation: A Legal Review of the State of the Art in Europe and the Case in Italy [PDF]
BioTech, 2021 The aim of this paper is to describe the essential points of Italian and European legislation governing the use of animals in biomedical experimentation.
Enrico Maestri
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The principle of the 3Rs between aspiration and reality
Frontiers in Physiology, 2022 The Principle of the 3Rs is widely recognised as the methodological and ethical backbone of contemporary animal research. Different authors also stress the reciprocal links among the 3Rs, and how these often complement and reinforce each other.
Augusto Vitale, Laura Ricceri
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Toward a common interpretation of the 3Rs principles in animal research. [PDF]
Lab Anim (NY)Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread ...
Lauwereyns J +21 more
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The 3Rs principle applied to laboratory experiments: from waste to potential new results [PDF]
Anais da Academia Brasileira de Ciências, 2023 ELIZABETH B.S. ALVES +5 more
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Contribution of multimodal ultrasound in evaluating the efficacy of lumbricus protein fast dissolving tablets against atherosclerotic plaques in ApoE(−/−) mice [PDF]
Frontiers in PharmacologyIntroductionAtherosclerosis (AS), a prevalent cardiovascular condition characterized by cholesterol accumulation, inflammation, and fibrous tissue proliferation within arterial walls, remains a major global health challenge. Traditional Chinese Medicine (
Zhihao Lu +8 more
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Longitudinal Analysis of Male Fertility Using an Acr‐Luc Knock‐In Mouse Model: A Preclinical Platform for Reproductive Toxicity Testing [PDF]
MedCommReproductive toxicity testing is essential for evaluating whether xenobiotics, including pharmaceuticals, environmental chemicals, or ionizing radiation, adversely affect reproductive function. However, conventional assessments rely on mating outcomes or
Hisanori Fukunaga +8 more
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Conceptual foundations for a clarified meaning of the 3Rs principles in animal experimentation. [PDF]
Anim WelfAbstract Russell and Burch’s 1959 original definitions of the 3Rs (replacement, reduction and refinement) are widely used today as standards for the ethical use of non-human animals in research, although they have a number of limitations. Authors and institutions around the world have addressed some of these, coming up in certain cases with more ...
Louis-Maerten E +4 more
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Incubation periods and mortality outcomes following rabies virus infection in mesocarnivorous reservoir hosts: implications for experimental design and veterinary policy – a review and meta-analysis [PDF]
Virology JournalBackground Efficacy studies are part of the regulatory requirements for obtaining marketing authorization for rabies virus vaccines intended for veterinary use.
Thomas Müller +3 more
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Ethical Considerations in Animal Research: The Principle of 3R’s [PDF]
Revista de Investigación Clínica, 2021 In the last century, progress in the knowledge of human diseases, their diagnosis and treatment have grown exponentially, due in large part to the introduction and use of laboratory animals. Along with this important progress, the need to provide training and guidance to the scientific community in all aspects related to the proper use of experimental ...
Lorenza, Díaz +12 more
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