Advancing the 3Rs: innovation, implementation, ethics and society
Frontiers in Veterinary Science, 2023 The 3Rs principle of replacing, reducing and refining the use of animals in science has been gaining widespread support in the international research community and appears in transnational legislation such as the European Directive 2010/63/EU, a number ...
Biller-Andorno Nikola +2 more
exaly +4 more sources
Reporting of 3Rs Approaches in Preclinical Animal Experimental Studies—A Nationwide Study
Animals, 2023 The 3Rs aim to refine animal welfare, reduce animal numbers, and replace animal experiments. Investigations disclose that researchers are positive towards 3Rs recommendations from peers.
Merel Ritskes-Hoitinga +2 more
exaly +4 more sources
Animals, 2023 Based on the current state of science, the use of animals remains essential in bringing safe and effective medicines to patients. Respect for laboratory animal welfare and the application of 3Rs principles (the replacement, reduction, and refinement of ...
Jessica Graham +2 more
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The 3Rs in Experimental Liver Disease
Animals, 2023 Patients with cirrhosis present multiple physiological and immunological alterations that play a very important role in the development of clinically relevant secondary complications to the disease.
Sebastian Martinez-Lopez +5 more
doaj +6 more sources
Animal Research in Otorhinolaryngology: Shifts in Publication and Practice Over Two Time Periods [PDF]
Turkish Archives of OtorhinolaryngologyObjective: The aim of this bibliometric analysis is to assess the evolving trends in animal research in otorhinolaryngology over two different time periods.
Ahmet Kısa
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The (re)turn of the 3Rs: an inquiry into the normative nature of Russell and Burch's principles of humane experimental technique - their misunderstanding, reform and implementation through an ethics tool. [PDF]
Lab AnimThe 3Rs strongly shape the practice of laboratory animal use, as well as related policies worldwide. This success should not obscure the fact that implementing the 3Rs comes with challenges. A major problem is that it is fundamentally unclear under which
Grimm H, Dusseldorp M.
europepmc +2 more sources
A modular three in one mucosal vaccine against three antigenic clusters of ACE2 using sarbecoviruses [PDF]
npj VaccinesThe recurrent emergence of ACE2‑using sarbecovirus underscores the need for a broadly protective vaccine. Here, we mapped the antigenic landscape of sarbecovirus receptor-binding domains (RBDs) and identified three distinct clusters. We then engineered a
Lin Liu +17 more
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25 years of applying the 3Rs principles in safety pharmacology: success stories and future perspectives [PDF]
Frontiers in PhysiologySafety pharmacology is a relatively young discipline dedicated to identifying adverse pharmacodynamic effects of new drugs that may impact human safety.
Katayoun Derakhchan +9 more
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Wildlife Biology, 2020 Research in ecology and wildlife biology remains crucial for increasing our knowledge and improving species management and conservation in the midst of the current biodiversity crisis.
Miriam A Zemanova
exaly +2 more sources
The principle of the 3Rs between aspiration and reality
Frontiers in Physiology, 2022 The Principle of the 3Rs is widely recognised as the methodological and ethical backbone of contemporary animal research. Different authors also stress the reciprocal links among the 3Rs, and how these often complement and reinforce each other.
Augusto Vitale, Laura Ricceri
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