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Animal Research in Otorhinolaryngology: Shifts in Publication and Practice Over Two Time Periods [PDF]

open access: yesTurkish Archives of Otorhinolaryngology
Objective: The aim of this bibliometric analysis is to assess the evolving trends in animal research in otorhinolaryngology over two different time periods.
Ahmet Kısa
doaj   +2 more sources

Reporting of 3Rs Approaches in Preclinical Animal Experimental Studies—A Nationwide Study

open access: yesAnimals, 2023
The 3Rs aim to refine animal welfare, reduce animal numbers, and replace animal experiments. Investigations disclose that researchers are positive towards 3Rs recommendations from peers.
Birgitte S. Kousholt   +6 more
doaj   +3 more sources

Advancing the 3Rs: innovation, implementation, ethics and society

open access: yesFrontiers in Veterinary Science, 2023
The 3Rs principle of replacing, reducing and refining the use of animals in science has been gaining widespread support in the international research community and appears in transnational legislation such as the European Directive 2010/63/EU, a number ...
Herwig Grimm   +12 more
doaj   +3 more sources

A modular three in one mucosal vaccine against three antigenic clusters of ACE2 using sarbecoviruses [PDF]

open access: yesnpj Vaccines
The recurrent emergence of ACE2‑using sarbecovirus underscores the need for a broadly protective vaccine. Here, we mapped the antigenic landscape of sarbecovirus receptor-binding domains (RBDs) and identified three distinct clusters. We then engineered a
Lin Liu   +17 more
doaj   +2 more sources

Implementing Culture of Care in Germany [PDF]

open access: yesAnimals
The implementation of the 3Rs principles is an essential part of daily routines and structural processes in animal research. The work of Russell and Burch regarding the 3Rs has been implemented in the field over the course of decades, but since 2002, the
Katharina Ameli, Stephanie Krämer
doaj   +2 more sources

Determinants of 3Rs behaviour in plastic usage: A study among Malaysians

open access: yesHeliyon, 2020
This research was conducted to explore the factors affecting Malaysians’ application of reduce, reuse and recycle (3Rs) concept in plastic usage. This study adopted variables from the Theory of Planned Behaviour (TPB), namely, attitude, subjective norm ...
Loh Chun T'ing   +7 more
doaj   +3 more sources

Fostering Animal Welfare and Advancing 3Rs Principles through the Establishment of a 3Rs Advisory Group

open access: yesAnimals, 2023
Based on the current state of science, the use of animals remains essential in bringing safe and effective medicines to patients. Respect for laboratory animal welfare and the application of 3Rs principles (the replacement, reduction, and refinement of ...
Jessica C. Graham   +6 more
doaj   +1 more source

The 3Rs applied to fruits and vegetables surpluses: virtuous examples from Italy

open access: yesFood Materials Research, 2023
When facing environmental issues associated with food waste, it is necessary to look upstream at the root causes. At the very beginning of the supply chain, there is the first cause of waste generation: unrecovered agriculture surpluses.
Francesca Girotto, Laura Piazza
doaj   +1 more source

Cytotoxicity assay as potential alternative method to animal testing for batch release of Italian fish autogenous vaccines

open access: yesOpen Veterinary Journal, 2023
Background: Vaccination is widely used in fish aquaculture for three primary reasons: to prevent bacterial disease spreading, minimize antibiotic use and fight antibiotic resistance.
Antonella Di-Paolo   +4 more
doaj   +1 more source

Impact of mono-culture vs. Co-culture of keratinocytes and monocytes on cytokine responses induced by important skin sensitizers

open access: yesJournal of Immunotoxicology, 2021
Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune system, as well ...
Venkatanaidu Karri   +4 more
doaj   +1 more source

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