Results 11 to 20 of about 37,025 (306)
Environmental Toxicology and Chemistry, EarlyView.There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system-disrupting chemicals (THSDCs) is an important requirement in the Organisation for ...
Lisa Gölz +9 more
semanticscholar +2 more sources
The principle of the 3Rs between aspiration and reality
Frontiers in Physiology, 2022 The Principle of the 3Rs is widely recognised as the methodological and ethical backbone of contemporary animal research. Different authors also stress the reciprocal links among the 3Rs, and how these often complement and reinforce each other.
Augusto Vitale, Laura Ricceri
doaj +2 more sources
Conceptual foundations for a clarified meaning of the 3Rs principles in animal experimentation
Animal WelfareRussell and Burch’s 1959 original definitions of the 3Rs (replacement, reduction and refinement) are widely used today as standards for the ethical use of non-human animals in research, although they have a number of limitations. Authors and institutions
Edwin Louis-Maerten +4 more
doaj +2 more sources
The (re)turn of the 3Rs: an inquiry into the normative nature of Russell and Burch's principles of humane experimental technique - their misunderstanding, reform and implementation through an ethics tool. [PDF]
Lab AnimThe 3Rs strongly shape the practice of laboratory animal use, as well as related policies worldwide. This success should not obscure the fact that implementing the 3Rs comes with challenges. A major problem is that it is fundamentally unclear under which
Grimm H, Dusseldorp M.
europepmc +2 more sources
The Case for Modernizing Biomedical Research in Ireland through the Creation of an Irish 3Rs Centre
Animals, 2022 Since its publication, the 3Rs principle has provided a cornerstone for more ethical and humane biomedical and regulatory research. In Europe, the 3Rs principle has been incorporated into the European Directive 63/2010/EU, with the ultimate aim of fully ...
Viola Galligioni +4 more
doaj +1 more source
Expert Review of Vaccines, 2023 Introduction Potency is a critical quality attribute for controlling quality consistency and relevant biological properties of vaccines. Owing to the high demand for animals, lengthy operations and high variability of in vivo methods, in vitro ...
Xuanxuan Zhang +6 more
doaj +1 more source
When adolescents stop psychological therapy: rupture-repair in the therapeutic alliance and association with therapy ending [PDF]
, 2020 therapeutic alliance consistently predicts dropout from psychological therapy, and ruptures in the therapeutic alliance may also predict dropout, yet there is a dearth of research with adolescents.
Martin, P., Midgley, N., O'Keeffe, S.
core +2 more sources
3Rs Principle and Legislative Decrees to Achieve High Standard of Animal Research
Animals, 2023 Simple Summary The 3Rs principle refers to three concepts: Replacement, Reduction and Refinement. These principles should be taken into consideration during the planning and execution of experiments by trying to replace the animal model with an ...
P. Verderio +5 more
semanticscholar +1 more source
Reforming global supply chain management under pandemics: The GREAT‐3Rs framework
Production and operations management, 2022 The recent outbreak of Coronavirus disease 2019 (COVID‐19) has posed serious threats and challenges to global supply chain management (GSCM). To survive the crisis, it is critical to rethink the proper setting of global supply chains and reform many ...
Xiaoyan Xu +3 more
semanticscholar +1 more source
Cleaner and Responsible Consumption, 2023 This study integrates environmental literacy and integrated behavioral model to address the reduce, reuse, and recycle (3Rs) issues of households in Malaysia.
Jing-Wei Law +2 more
doaj +1 more source