Results 11 to 20 of about 14,239 (267)

Implementing Culture of Care in Germany [PDF]

open access: yesAnimals
The implementation of the 3Rs principles is an essential part of daily routines and structural processes in animal research. The work of Russell and Burch regarding the 3Rs has been implemented in the field over the course of decades, but since 2002, the
Katharina Ameli, Stephanie Krämer
doaj   +2 more sources

3Rs Principle and Legislative Decrees to Achieve High Standard of Animal Research

open access: yesAnimals, 2023
Animal experimentation is a vast ecosystem that tries to make different issues such as legislative, ethical and scientific coexist. Research in animal experimentation has made many strides thanks to the 3Rs principle and the attached legislative decrees,
Paolo Verderio   +5 more
doaj   +2 more sources

Conceptual foundations for a clarified meaning of the 3Rs principles in animal experimentation

open access: yesAnimal Welfare
Russell and Burch’s 1959 original definitions of the 3Rs (replacement, reduction and refinement) are widely used today as standards for the ethical use of non-human animals in research, although they have a number of limitations. Authors and institutions
Edwin Louis-Maerten   +4 more
doaj   +2 more sources

The 3Rs Principle in Animal Experimentation: A Legal Review of the State of the Art in Europe and the Case in Italy

open access: yesBioTech, 2021
The aim of this paper is to describe the essential points of Italian and European legislation governing the use of animals in biomedical experimentation.
Enrico Maestri
exaly   +2 more sources

Development of a Zebrafish Embryo-Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research.

open access: yesEnvironmental Toxicology and Chemistry, EarlyView.
There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system-disrupting chemicals (THSDCs) is an important requirement in the Organisation for ...
Lisa Gölz   +9 more
semanticscholar   +2 more sources

Cephalopods in neuroscience: regulations, research and the 3Rs [PDF]

open access: yesInvertebrate Neuroscience, 2014
Cephalopods have been utilised in neuroscience research for more than 100 years particularly because of their phenotypic plasticity, complex and centralised nervous system, tractability for studies of learning and cellular mechanisms of memory (e.g. long-term potentiation) and anatomical features facilitating physiological studies (e.g.
Carlo Di Cristo   +2 more
exaly   +10 more sources

The 3Rs applied to fruits and vegetables surpluses: virtuous examples from Italy

open access: yesFood Materials Research, 2023
When facing environmental issues associated with food waste, it is necessary to look upstream at the root causes. At the very beginning of the supply chain, there is the first cause of waste generation: unrecovered agriculture surpluses.
Francesca Girotto, Laura Piazza
doaj   +1 more source

Cytotoxicity assay as potential alternative method to animal testing for batch release of Italian fish autogenous vaccines

open access: yesOpen Veterinary Journal, 2023
Background: Vaccination is widely used in fish aquaculture for three primary reasons: to prevent bacterial disease spreading, minimize antibiotic use and fight antibiotic resistance.
Antonella Di-Paolo   +4 more
doaj   +1 more source

Impact of mono-culture vs. Co-culture of keratinocytes and monocytes on cytokine responses induced by important skin sensitizers

open access: yesJournal of Immunotoxicology, 2021
Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune system, as well ...
Venkatanaidu Karri   +4 more
doaj   +1 more source

The 3Rs of Cell Therapy [PDF]

open access: yesStem Cells Translational Medicine, 2016
Abstract The 3Rs for a good education are “reading, 'riting, and 'rithmetic.” The basis for good health care solutions for the emergent field of cell therapy in the future will also involve 3Rs: regulation, reimbursement, and realization of value. The business models in this new field of cell therapy will involve these 3Rs.
Caplan, AI, Mason, C, Reeve, B
openaire   +3 more sources

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