Results 11 to 20 of about 13,325 (255)
Advancing the 3Rs: innovation, implementation, ethics and society [PDF]
Frontiers in Veterinary Science, 2023 The 3Rs principle of replacing, reducing and refining the use of animals in science has been gaining widespread support in the international research community and appears in transnational legislation such as the European Directive 2010/63/EU, a number ...
Elin Tornqvist +2 more
exaly +6 more sources
Animals, 2023 Based on the current state of science, the use of animals remains essential in bringing safe and effective medicines to patients. Respect for laboratory animal welfare and the application of 3Rs principles (the replacement, reduction, and refinement of ...
Jessica C Graham +2 more
exaly +4 more sources
Reporting of 3Rs Approaches in Preclinical Animal Experimental Studies—A Nationwide Study
Animals, 2023 The 3Rs aim to refine animal welfare, reduce animal numbers, and replace animal experiments. Investigations disclose that researchers are positive towards 3Rs recommendations from peers.
Birgitte S Kousholt +2 more
exaly +4 more sources
The Case for Modernizing Biomedical Research in Ireland through the Creation of an Irish 3Rs Centre
Animals, 2022 Since its publication, the 3Rs principle has provided a cornerstone for more ethical and humane biomedical and regulatory research. In Europe, the 3Rs principle has been incorporated into the European Directive 63/2010/EU, with the ultimate aim of fully ...
Viola Galligioni +2 more
exaly +4 more sources
Researchers' attitudes to the 3Rs-An upturned hierarchy? [PDF]
PLoS ONE, 2018 Animal use in biomedical research is generally justified by its potential benefits to the health of humans, or other animals, or the environment. However, ethical acceptability also requires scientists to limit harm to animals in their research. Training
Nuno Henrique Franco +2 more
doaj +8 more sources
Animal Research in Otorhinolaryngology: Shifts in Publication and Practice Over Two Time Periods [PDF]
Turkish Archives of OtorhinolaryngologyObjective: The aim of this bibliometric analysis is to assess the evolving trends in animal research in otorhinolaryngology over two different time periods.
Ahmet Kısa
doaj +2 more sources
A modular three in one mucosal vaccine against three antigenic clusters of ACE2 using sarbecoviruses [PDF]
npj VaccinesThe recurrent emergence of ACE2‑using sarbecovirus underscores the need for a broadly protective vaccine. Here, we mapped the antigenic landscape of sarbecovirus receptor-binding domains (RBDs) and identified three distinct clusters. We then engineered a
Lin Liu +17 more
doaj +2 more sources
Lipids in Health and Disease, 2018 Background Among the eight stereoisomers of phytanic acid (PA), the 3RS, 7R, 11R-isomer is naturally occurring and is present in foods and the human body. PA is considered to have possible health benefits in the immune system.
Tomonori Nakanishi +9 more
doaj +3 more sources
25 years of applying the 3Rs principles in safety pharmacology: success stories and future perspectives [PDF]
Frontiers in PhysiologySafety pharmacology is a relatively young discipline dedicated to identifying adverse pharmacodynamic effects of new drugs that may impact human safety.
Katayoun Derakhchan +9 more
doaj +2 more sources
The principle of the 3Rs between aspiration and reality
Frontiers in Physiology, 2022 The Principle of the 3Rs is widely recognised as the methodological and ethical backbone of contemporary animal research. Different authors also stress the reciprocal links among the 3Rs, and how these often complement and reinforce each other.
Augusto Vitale, Ricceri Laura
exaly +3 more sources