Results 11 to 20 of about 11,399 (169)
Journal of Immunotoxicology, 2021 Sensitization to a contact allergen brings with it a lifelong risk to develop allergic contact dermatitis. Inflammation is an important part of the skin sensitizing mechanism, and understanding how different haptens stimulate the immune system, as well ...
Venkatanaidu Karri +4 more
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Advancing Regulatory Adoption of New Approach Methodologies. [PDF]
Clin Pharmacol TherThe U.S. Food and Drug Administration (FDA) Center for Drug Evaluation and Research (CDER) has a long history advancing new approach methodologies (NAMs). In collaboration with external organizations and other regulatory agencies, FDA supports continued development of NAMs for regulatory use.
Florian J +7 more
europepmc +2 more sources
Expert Review of Vaccines, 2023 Introduction Potency is a critical quality attribute for controlling quality consistency and relevant biological properties of vaccines. Owing to the high demand for animals, lengthy operations and high variability of in vivo methods, in vitro ...
Xuanxuan Zhang +6 more
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Advancing the 3Rs: innovation, implementation, ethics and society
Frontiers in Veterinary Science, 2023 The 3Rs principle of replacing, reducing and refining the use of animals in science has been gaining widespread support in the international research community and appears in transnational legislation such as the European Directive 2010/63/EU, a number ...
Herwig Grimm +12 more
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The principle of the 3Rs between aspiration and reality
Frontiers in Physiology, 2022 The Principle of the 3Rs is widely recognised as the methodological and ethical backbone of contemporary animal research. Different authors also stress the reciprocal links among the 3Rs, and how these often complement and reinforce each other.
Augusto Vitale, Laura Ricceri
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Cleaner and Responsible Consumption, 2023 This study integrates environmental literacy and integrated behavioral model to address the reduce, reuse, and recycle (3Rs) issues of households in Malaysia.
Jing-Wei Law +2 more
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Adaptability evaluation of a product upgradability (Application of a laptop computer design)
Nihon Kikai Gakkai ronbunshu, 2017 To make sustainable society come true, product design is required to consider environmental issues such as reduction of resource usage, product disposal, and environmental loads.
Chise SHIBATA +3 more
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Laboratory Animal Welfare Approach in Science
Southeastern European Medical Journal, 2020 The term laboratory animal welfare has been generating a huge amount of controversial questions in science since the very beginning. Humans use animals that are suited to their needs, be they of a psychosocial, therapeutic, official, scientific or ...
Iris Broman
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Comparison of hair steroid levels among Wistar rats exposed to different environmental enrichment settings [PDF]
Veterinary WorldBackground and Aim: Environmental enrichment (EE) is a pivotal tool for creating ideal housing conditions that allow animals to fully display their ethograms.
Alberto Elmi +7 more
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Open Biology, 2022 Neurons encounter unavoidable evolutionary trade-offs between multiple tasks. They must consume as little energy as possible while effectively fulfilling their functions. Cells displaying the best performance for such multi-task trade-offs are said to be
Peter Jedlicka +2 more
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