Results 31 to 40 of about 14,239 (267)

Pareto optimality, economy–effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons

Open Biology, 2022
Neurons encounter unavoidable evolutionary trade-offs between multiple tasks. They must consume as little energy as possible while effectively fulfilling their functions. Cells displaying the best performance for such multi-task trade-offs are said to be
Peter Jedlicka, Alexander D. Bird, Hermann Cuntz   +2 more
doaj   +1 more source

Editorial: 3Rs—Strategies for reduction and refinement of animal studies

Frontiers in Pharmacology, 2023
Ethical guidelines in animal experimentation were defined as early as 1831 by the British psychologist Marshall Hall (Gorzalczany and Rodriguez Basso, 2021).
E. Fröhlich, George Loizou
semanticscholar   +1 more source

Comparison of hair steroid levels among Wistar rats exposed to different environmental enrichment settings [PDF]

Veterinary World
Background and Aim: Environmental enrichment (EE) is a pivotal tool for creating ideal housing conditions that allow animals to fully display their ethograms.
Alberto Elmi, Niccolò I. Vannetti, Viola Galligioni, Nadia Govoni, Camilla Aniballi, José M. Sánchez-Morgado, Maria L. Bacci, Domenico Ventrella   +7 more
doaj   +1 more source

Animal-Assisted Interventions and Animal Welfare—An Exploratory Survey in Germany

Animals, 2023
Background: Animals play a crucial role in social occupational fields. The positive effects of animals are described in theory and practice. However, the significance of animal welfare in animal-assisted intervention settings has not yet been extensively
Katharina Ameli, Theresa F. Braun, Stephanie Krämer   +2 more
doaj   +1 more source

Software Engineering Practices in Academia: Promoting the 3Rs—Readability, Resilience, and Reuse

Issue 5.2, Spring 2023, 2023
Over the past decade as data science has become integral to the research workflow, we, like many others, have learned that good data science requires high-quality software engineering.
Andrew Connolly, J. Hellerstein, Naomi Alterman, David A. C. Beck, R. Fatland, Ed Lazowska, Vani Mandava, S. Stone   +7 more
semanticscholar   +1 more source

Self-Portrait of a Bible: The Ezra Image of Codex Amiatinus

Religions, 2022
Dating from the early 8th century and created in Anglo-Saxon Northumbria, Codex Amiatinus is the oldest intact single-volume Bible in any language. Within its extensive prefatory material is an image of Ezra, the scribe who according to legend rewrote ...
Francis Benedict Watson
doaj   +1 more source

Preclinical Tendon and Ligament Models: Beyond the 3Rs (Replacement, Reduction, and Refinement) to 5W1H (Why, Who, What, Where, When, How)

Journal of Orthopaedic Research, 2023
Several tendon and ligament animal models were presented at the 2022 Orthopaedic Research Society Tendon Section Conference held at the University of Pennsylvania, May 5 to 7, 2022.
D. Little, P. Amadio, Hani A. Awad, S. Cone, N. Dyment, M. Fisher, A. Huang, D. Koch, A. Kuntz, Rashad Madi, Kirk McGilvrey, L. Schnabel, S. Shetye, S. Thomopoulos, Chunfeng Zhao, L. Soslowsky   +15 more
semanticscholar   +1 more source

Genetics and Glaucoma: the state of the art

Frontiers in Medicine, 2023
Glaucoma is the second leading cause of irreversible blindness worldwide. Although genetic background contributes differently to rare early-onset glaucoma (before age 40) or common adult-onset glaucoma, it is now considered an important factor in all ...
Sara Tirendi, Sara Tirendi, Cinzia Domenicotti, Cinzia Domenicotti, Anna Maria Bassi, Anna Maria Bassi, Stefania Vernazza, Stefania Vernazza   +7 more
doaj   +1 more source

The Review of Existing Strategies of End-of-Life Graphite Anode Processing Using 3Rs Approach: Recovery, Recycle, Reuse

Batteries, 2023
While past recycling efforts have primarily concentrated on extracting valuable metals from discarded cathode materials, the focus is now shifting towards anode materials, particularly graphite, which makes up 10–20% of LIB mass.
Alexandra Kosenko, Konstantin Pushnitsa, Alexander A. Pavlovskii, P. Novikov, A. Popovich   +4 more
semanticscholar   +1 more source

Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment

Frontiers in Oncology, 2023
Three-dimensional cell culture technology (3DCC) sits between two-dimensional cell culture (2DCC) and animal models and is widely used in oncology research.
Long Zhang, Weiqi Liao, Shimin Chen, Yukun Chen, Pengrui Cheng, Xinjun Lu, Yi Ma   +6 more
semanticscholar   +1 more source