Results 111 to 120 of about 3,224 (210)

Buccal swabs for long-term DNA storage in conservation genetics of fish: One-and-a-half-year analysis timeframe

Global Ecology and Conservation
Conservation genetic research is essential for the management and recovery of endangered taxa. However, the invasive collection of biological material for DNA analysis is controversial.
Simona Sciuto, Silvia Colussi, Giuseppe Esposito, Arianna Meletiadis, Marino Prearo, Elisabetta Pizzul, Pier Luigi Acutis, Rodolphe Elie Gozlan, Paolo Pastorino   +8 more
doaj   +1 more source

Overproduction of 42 Amino Acids Long Amyloid Beta Leads to Activation of Secretory Autophagy and Development of Drusen‐Like Structures Originating From Retinal Pigment Epithelium

The FASEB Journal, Volume 40, Issue 5, 15 March 2026.
The role of 42 amino acids long amyloid beta (Aβ) in the retinal pigment epithelium (RPE) was investigated using 5xFAD mice model overproducing Aβ. The RPE cells of 5xFAD mice showed increased oxidative stress, accumulation of autophagy‐destined proteins, increased expression of secretory autophagy markers, and increase in epithelial‐to‐mesenchymal ...
Johanna Ruuth, Toni Tamminen, Elisa Toropainen, Heikki Tanila, Juha M. T. Hyttinen, Tarja Malm, Kai Kaarniranta, Ali Koskela   +7 more
wiley   +1 more source

Advanced In Vitro Models for Preclinical Drug Safety: Recent Progress and Prospects

Current Issues in Molecular Biology
The majority of drugs are typically orally administered. The journey from drug discovery to approval is often long and expensive, involving multiple stages.
Dileep G. Nair, Ralf Weiskirchen
doaj   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, Volume 15, Issue 9, 6 March 2026.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

In vivo fertilization improved the cryotolerance and developmental ability of vitrified-warmed rat fertilized oocytes

Scientific Reports
The cryopreservation of rat embryos is useful for efficiently archiving rat resources in bioresource repositories. The cryopreserved fertilized oocytes can be quickly reanimated to rats with homozygous mutations using embryo transfer.
Yuta Ishizuka, Satohiro Nakao, Tsutomu Kamisako, Katsuma Yamaga, Naomi Nakagata, Hiroyoshi Ishizaki, Toru Takeo   +6 more
doaj   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source

An In vitro Caco2‐Based Model for Measuring Intestinal Bioadhesion Comparable to Ex vivo Models

Small Science
This study presents an in vitro model using Caco‐2 cells that can mimic the bioadhesion properties of the human intestinal epithelium, aiming to reduce the use of animal tissues, in line with the 3Rs principle—replacement, reduction, and refinement ...
Eliyahu Drori, Valeria Rahamim, Dhaval Patel, Yamm Anker, Sivan Meir, Gal Uzan, Shira Somech, Chen Drori, Tal Tzadok, Aharon Azagury   +9 more
doaj   +1 more source

Comparative Analysis of Akerma and Bouchouk Guergour Olive Oils Varieties: Physicochemical Analysis, Quality, and Bioactivity Evaluation

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
ABSTRACT The current study investigated the dynamic of the ripening process, oil yield, physicochemical properties, and wound healing activity of two olive varieties, namely Akerma and Bouchouk Guergour. The ripening index revealed that Akerma matured at a slower rate compared to the Bouchouk Guergour variety.
Samir Sahli, Nabila Souilah, Hamdi Bendif, Amar Benmahammed, Saliha Dahamna, Ramazan Erenler, Walid Elfalleh, İbrahim Demirtaş, Fehmi Boufahja, Stefania Garzoli   +9 more
wiley   +1 more source

Long‐Term Low‐Dose of Nitrate Administration Improves Antioxidant Defence System in Insulin‐Sensitive Tissues of Type 2 Diabetic Rats

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
Long‐term nitrate administration at low doses has a protective effect against oxidative stress in the liver, soleus muscle (SM) and epididymal adipose tissue (eAT) of male rats with type 2 diabetes (T2D). ABSTRACT Introduction Type 2 diabetes (T2D) is characterised by increased oxidative stress, which contributes to insulin resistance in insulin ...
Fatemeh Ghorbani, Majid Shokri, Sajad Jeddi, Asghar Ghasemi   +3 more
wiley   +1 more source

Noninvasive 11.7‐T Magnetic Resonance Spectroscopy and Imaging Reveals Retinal Metabolic Alterations Induced by Blue Light Exposure

NMR in Biomedicine, Volume 39, Issue 3, March 2026.
Retinal metabolic changes were analyzed using proton magnetic resonance spectroscopy (1H‐MRS), marking an initial application of this non‐invasive method on living eyes. Key metabolites were identified within the retinal region of adult rats. The observed changes following intense blue light exposure were predominantly attributable to the retina, as it
Lacramioara Samoila, Alexandru Farcasanu, Simion Simon, Ede Bodoki, Ovidiu Samoila, Oliviu Vostinaru, Elena Dinte, Andreea Elena Bodoki, Dan Iudean, Calin Muresan, Simona Clichici   +10 more
wiley   +1 more source