Results 121 to 130 of about 3,224 (210)

Alternative methods to animal experimentation in rabbit nutrition trials integrating the 3Rs principles

World Rabbit Science
Animal studies are essential to nutrition research, particularly in investigating the effects of dietary changes on animal growth, reproduction, health and metabolism. These studies provide quantitative data on feedstuffs’ nutritive value and animal response to diets, indispensable for building accurate nutrient databases and defining animal nutrient ...
María Cambra-López, Javier García, Juan José Pascual, Nuria Nicodemus   +3 more
openaire   +3 more sources

A Multi‐Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice

Aging Cell, Volume 25, Issue 3, March 2026.
A gut‐derived metabolic signature drives systemic aging phenotypes. Integrated multi‐omics profiling of young versus aged mice identifies a conserved aging signature characterized by the depletion of protective lysophosphatidylcholines (LPC 22:0) and the concurrent accumulation of pro‐oxidative microbial catabolites (TMAO, IAA).
Sanaullah Sajid, Jieliang Huang, Shaofang Kong, Chengze Lai, Zhuoxin Tan, Yiming Shao, Lianxian Guo   +6 more
wiley   +1 more source

Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer

Cancer Science, Volume 117, Issue 3, Page 683-694, March 2026.
YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh, Akihiro Nita, Yudai Ohta, Aya Kobayashi, Hao Li, Yasuhisa Sakamoto, Toshiro Moroishi   +6 more
wiley   +1 more source

Deficiency of Tissue Nonspecific Alkaline Phosphatase Dysregulates Microglial Morphology and Function in a Mouse Model of Infantile Hypophosphatasia

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
Using male and female tissue‐nonspecific alkaline phosphatase (TNAP) knockout (KO) and wild type (WT) mice, we show TNAP loss impairs growth and sensorimotor function and induces marked microglial morphological changes (enlarged soma, retracted processes).
Kareem Elaswad, Yara Mashal, Iyah Nasser, Linna Almhanaa, Chloe Grabowski, Zhi Zhang   +5 more
wiley   +1 more source

LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models

Journal of Neurochemistry, Volume 170, Issue 3, March 2026.
In vitro, low‐density lipoprotein cholesterol (LDL cholesterol) promotes the accumulation of lipid derivatives in astrocytes. Additionally, LDL cholesterol exposure causes a decrease in the expression of low‐density lipoprotein receptor (LDLr), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase (HMGCR), and sterol regulatory element‐binding transcription factor ...
Gabriela Joras Baumart, Matheus Scarpatto Rodrigues, Juliete Nathali Sholl, Arieli Cruz de Sousa, Augusto Ferreira Weber, Lílian Corrêa Costa‐Beber, Hémelin Resende Farias, Mariana Viana Costa, Ariadni Mesquita Peres, Pedro Rocha de Camargo, Fernanda Telles Fróes, Rachel Krolow Bast, Andreza Fabro de Bem, Fabrício Figueiró, Fátima T. C. R. Guma, Jade de Oliveira   +15 more
wiley   +1 more source

Human Derived Exosome Injections (ASCE+ vs. CELLEXOSOME) Enhance Collagen Remodeling and Angiogenesis in Intact Skin: A Comparative Experimental Study

Journal of Cosmetic Dermatology, Volume 25, Issue 3, March 2026.
ABSTRACT Background Exosomes derived from human cells have emerged as promising biological agents for enhancing skin quality through stimulation of collagen remodeling and angiogenesis. While their role in wound healing is well established, their effects on intact, non‐injured skin remain insufficiently investigated.
Noury Adel, Jack Kolenda, Francisco Llano, Jesper Thulesen, Francisco Hernandez Gomez Crespo, Yundun Shen, Youn Kyong Jo, Gabriela Yareli Zavala Resendiz, Diego Ivan Briseno Torres, Jesus Alejandro Lopez‐Lara, Ida Vega Thulesen   +10 more
wiley   +1 more source

Comparison of Human and Canine P‐Glycoprotein Substrates at R, P, and H Binding Sites

Journal of Veterinary Pharmacology and Therapeutics, Volume 49, Issue 2, Page 120-130, March 2026.
ABSTRACT P‐glycoprotein (P‐gp) greatly impacts substrate drug disposition, so much so that regulatory agencies recommend ascertaining the P‐gp status of active pharmaceutical ingredients (APIs) intended for human use. Arguably, the P‐gp status of drugs intended for canine patients is equally, if not more, important.
Neal S. Burke, Katrina L. Mealey
wiley   +1 more source

Antenatal betamethasone impairs markers of cardiac development and function in near‐term lambs

Experimental Physiology, Volume 111, Issue 3, Page 988-1007, 1 March 2026.
Abstract figure Summary of key molecular differences in the left ventricle of near‐term lambs exposed to antenatal betamethasone, compared to saline. Pregnant ewes received two doses of either saline (Saline) or betamethasone (Betamethasone, intramuscular, 11.4 mg) given 24 h apart, before delivery at 140 days of gestation (dG, term = 150 dG).
Reza Amanollahi, Ashley S. Meakin, Stacey L. Holman, Vicki L. Clifton, Kent L. Thornburg, Michael D. Wiese, Kathryn L. Gatford, Mitchell C. Lock, Janna L. Morrison   +8 more
wiley   +1 more source

Lactate supplementation modulates molecular and functional responses during chronic neuromuscular electrical stimulation in male rats

Physiological Reports, Volume 14, Issue 5, March 2026.
Abstract Lactate is increasingly recognized as a signaling molecule that modulates muscle plasticity. We examined the effects of oral L‐sodium lactate supplementation on skeletal muscle adaptation to chronic neuromuscular electrical stimulation (NMES) in rats.
Toshinori Yoshihara, Yasushi Koriyama, Sakura Ogawa, Hisashi Naito   +3 more
wiley   +1 more source

Modern Approach to Testing the Biocompatibility of Osteochondral Scaffolds in Accordance with the 3Rs Principle─Preclinical In Vitro, Ex Vivo, and In Vivo Studies Using the Biphasic Curdlan-Based Biomaterial. [PDF]

ACS Biomater Sci Eng
Klimek K, Terpilowska S, Michalak A, Bernacki R, Nurzynska A, Cucchiarini M, Tarczynska M, Gaweda K, Głuszek S, Ginalska G.   +9 more
europepmc   +1 more source