Results 21 to 30 of about 3,224 (210)
In Vitro Tests for Assessing the Neutralizing Ability of Snake Antivenoms: Toward the 3Rs Principles
Frontiers in Immunology, 2021 There is an urgent need to strengthen the implementation of the 3Rs principle (Replacement, Reduction and Refinement) in the use of experimental animals in toxinological research and in the assessment of the neutralizing efficacy of snake antivenoms ...
José María Gutiérrez +8 more
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Marmoset angiography just by percutaneous puncture of the caudal ventral artery.
PLoS ONE, 2021 Surgery in humans is continuously evolving and promoted minimally invasive treatment. On the other hand, despite the importance of the 3Rs principles for experimental animals is well documented, no reports describe specific methodologies for implementing
Hiroki Ohta +5 more
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Animals, 2023 Longitudinal studies on mouse models related to Alzheimer disease (AD) pathology play an important role in the investigation of therapeutic targets to help pharmaceutical research in the development of new drugs and in the attempt of an early diagnosis ...
Giovanna Palumbo +8 more
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Post-Mortem Extracorporeal Membrane Oxygenation Perfusion Rat Model: A Feasibility Study
Animals, 2023 The development of biomedical soft- or hardware frequently includes testing in animals. However, large efforts have been made to reduce the number of animal experiments, according to the 3Rs principle.
Matthias Manfred Deininger +7 more
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Gonadal sex and animal experimentation: Perfection vs. 3R principle? [PDF]
Basic & Clinical Pharmacology & Toxicology, 2020 AbstractReplicability of experimental results and optimal use of experimental animals are everybody's concern. Current efforts towards increased replicability include guidelines and checklists as tools for experimenters, referees, editors and publishers. Guidelines are also provided for appropriate use of animals.
Peter Bie, Birgit Debrabant
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Considering aspects of the 3Rs principles within experimental animal biology [PDF]
Journal of Experimental Biology, 2017 ABSTRACT The 3Rs – Replacement, Reduction and Refinement – are embedded into the legislation and guidelines governing the ethics of animal use in experiments. Here, we consider the advantages of adopting key aspects of the 3Rs into experimental biology, represented mainly by the fields of animal behaviour, neurobiology, physiology ...
Lynne U. Sneddon +2 more
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BioTechniques, 2021 Routine cell culture demands the use of animal-derived products, mainly fetal bovine serum and swine or bovine trypsin. According to the 3Rs principle and to the European Centre for the Validation of Alternative Methods, animal-free substitutes are ...
Mara Fusi, Silvia Dotti
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Invasive Research on Non-Human Primates—Time to Turn the Page
Animals, 2021 Invasive research on primates (i.e., laboratory research that implies body manipulations causing pain or distress that is not aimed to directly improve the individuals’ well-being) has a long history. Although some invasive studies have allowed answering
Maria Padrell +2 more
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Advances in Science and Research, 2010 This article provides an overview of the ethical issues raised by the use of non-human primates (NHPs) in research involving scientific procedures which may cause pain, suffering, distress or lasting harm. It is not an exhaustive review of the literature
M. J. Prescott
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Research on Rural Landscape Design Based on 3R Principle
Journal of Physics: Conference Series, 2020 Abstract In recent years, the pace of beautiful countryside construction in China has been accelerating, which has promoted the development of rural tourism industry and is of great significance to the economic development of vast rural areas.
Yi Shi +3 more
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