Results 41 to 50 of about 3,224 (210)
Replacement Strategies for Animal Studies in Inhalation Testing
Sci, 2021 Animal testing is mandatory in drug testing and is the gold standard for toxicity and efficacy evaluations. This situation is expected to change in the future as the 3Rs principle, which stands for the replacement, reduction, and refinement of the use of
Eleonore Fröhlich
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Ethical Considerations for Echinoderms: New Initiatives in Welfare
Animals, 2023 This paper explores the ethical considerations surrounding research on echinoderms, a group of invertebrates that has recently garnered attention in the scientific community.
Augusto César Crespi-Abril +1 more
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Development of In Vitro Corneal Models: Opportunity for Pharmacological Testing
Methods and Protocols, 2020 The human eye is a specialized organ with a complex anatomy and physiology, because it is characterized by different cell types with specific physiological functions.
Valentina Citi +4 more
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The 3R Principles for Applying Biochar to Improve Soil Health [PDF]
Soil Systems, 2020 Amending soil with biochar is a promising approach to persistently improve soil health and promote crop growth. The efficacy of soil biochar amendment, however, is soil specific, biochar dependent, and influenced by the biochar application programs.
openaire +2 more sources
Drug Screening, Oral Bioavailability and Regulatory Aspects: A Need for Human Organoids
Pharmaceutics, 2021 The intestinal epithelium critically contributes to oral bioavailability of drugs by constituting an important site for drug absorption and metabolism.
Tamara Zietek +2 more
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Mokslas: Lietuvos Ateitis, 2018 In the context of globalization, with a rapid drop in natural resources and an increase in the amount of waste an effective tool for boosting business competitiveness is the bioeconomy. The purpose of the article is to review the standpoint of scientists
Alfred Šostko, Artūras Jakubavičius
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Production of marmoset eggs and embryos from xenotransplanted ovary tissues
Scientific Reports, 2023 The common marmoset (Callithrix jacchus) has attracted attention as a valuable primate model for the analysis of human diseases. Despite the potential for primate genetic modification, however, its widespread lab usage has been limited due to the ...
Runa Hirayama +14 more
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Advanced Healthcare Materials, EarlyView.Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram +10 more
wiley +1 more source
Optimization Strategy for 5C Principles, 7P Principles, and 3R Principles in Banking Law
Jurnal Sains IndonesiaThis research examines the introduction of the 5C, 7P and 3R principles in banking law. This research uses legal data, namely primary legal evidence and secondary legal evidence. This research focuses on library research, which means diving deeper into the applicable laws and regulations. Principles in banking law are very important, considering that a
Brian Kusuma Jala Wibowo +4 more
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