Results 51 to 60 of about 3,224 (210)
Application of 3R principles in small animal GLP testing of biomaterials [PDF]
Current Directions in Biomedical Engineering, 2019 Abstract On the protection of animals used for scientific purposes, the EU Parliament adopted Directive 2010/63/EU. The essential factor is the 3R principle: Replacement, Reduction and Refinement. In 2013, the third amendment to the German Animal Welfare Act was revised and adapted to the European Directive.
Kischkel Sabine +5 more
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Advanced Healthcare Materials, EarlyView.This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre +3 more
wiley +1 more source
Annali dell'Istituto Superiore di Sanità, 2011 Reproductive toxicity, with its many targets and mechanisms, is a complex area of toxicology; thus, the screening and identification of reproductive toxicants is a main scientific challenge for the safety assessment of chemicals, including the European ...
Stefano Lorenzetti +17 more
doaj +1 more source
3R-Refinement principles: elevating rodent well-being and research quality
Laboratory Animal ResearchAbstractThis review article delves into the details of the 3R-Refinement principles as a vital framework for ethically sound rodent research laboratory. It highlights the core objective of the refinement protocol, namely, to enhance the well-being of laboratory animals while simultaneously improving the scientific validity of research outcomes. Through
Puneet Rinwa +3 more
openaire +4 more sources
Advanced Healthcare Materials, EarlyView.Wound closure is governed by geometry‐orientation coupling: aligned fibers speed migration along their axis but hinder perpendicular advance. In vivo diabetic wound experiments with composition‐matched fibrin, combined with an anisotropic diffusion (biased random‐walk) model, quantify this trade‐off and generate a healing landscape.
Yin‐Yuan Huang +13 more
wiley +1 more source
Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice
Advanced Healthcare Materials, EarlyView.A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec +5 more
wiley +1 more source
Ethical aspects of animal use in scientific research
Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні наукиThe study identified key challenges related to the use of laboratory animals in scientific research and outlined directions for improving ethical oversight in light of current scientific and moral standards.
S. V. Huralska +6 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani +7 more
wiley +1 more source
The 3R principle: advancing clinical application of human pluripotent stem cells [PDF]
Stem Cell Research & Therapy, 2013 The first derivation of human embryonic stem cells brought with it a clear understanding that animal models of human disease might be replaced by an unlimited supply of human cells for research, drug discovery, and drug development. With the advent of clinical trials using human pluripotent stem cell-based therapies, it is both timely and relevant to ...
openaire +3 more sources
Digital Microneedles for Multiplexed Transdermal Sensing via Fluorescent QR Codes
Advanced Materials, EarlyView.Digital fluorescent microneedles encode biochemical information in skin into scannable QR codes through threshold‐activated probes that generate binary on/off signals. By transforming analog fluorescence into discrete digital patterns, this platform enables calibration‐free, multiplexed transdermal sensing of physiologically relevant biomarkers ...
Farbod Abazar +7 more
wiley +1 more source