Results 61 to 70 of about 3,224 (210)
Promoting the welfare of animals utilized in neuroscience research
Brain-XThe safeguarding of animal welfare holds a deep‐rooted history within public institutions and legislative structures, with the objective of enhancing the comfort and overall wellbeing of animals throughout the entire experimental process. It is paramount
Tianshuo Zhang +5 more
doaj +1 more source
The Potential of Zebrafish Larvae and Water Vortex Protocols in Stress Biology
EndocrinesStress responses enable vertebrates to adapt to environmental challenges while maintaining homeostasis. Zebrafish larvae are a valuable model for studying stress regulation due to their genetic accessibility and rapid development.
Rodrigo J. De Marco
doaj +1 more source
Toxics, 2022 Recently, an increasing number of chemical compounds are being characterized as endocrine disruptors since they have been proven to interact with the endocrine system, which plays a crucial role in the maintenance of homeostasis. Glyphosate is the active
Vasiliki Karzi +13 more
doaj +1 more source
Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization
Advanced Materials, EarlyView.A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab +8 more
wiley +1 more source
Animals, 2023 Stereotaxic surgeries enable precise access to specific brain regions, being of particular interest for chronic intracerebroventricular drug delivery. However, the challenge of long-term studies at this level is to allow the implantation of drug storage ...
Ester Pérez-Martín +9 more
doaj +1 more source
The 3Rs principle – mind the ethical gap! [PDF]
, 2012 Over the 50 years since they were first proposed, the 3Rs (Replacement, Reduction, Refinement) have made a tremendous impact. These principles seem to unify concerns for better science with causing less harm to animals. The ideas behind the 3Rs are so intuitively compelling that it is tempting to believe that full implementation is merely a matter of ...
Olsson, I. Anna S. +3 more
openaire
Principles of the 3Rs and ARRIVE Guidelines in Animal Research
Indonesian Journal of Cardiology, 2017 The use of animals in research has concerned the general public and thoughtful researchers for a long time. For improved animal welfare and increased research quality, researchers have moral obligations to include the 3Rs. The Three Rs are basic principles of humane experimental technique that were first set out by Russell and Burch in 1959.
Djanggan Sargowo +2 more
openaire +2 more sources
A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions
Advanced Science, EarlyView.This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies +14 more
wiley +1 more source
Are slaughterhouse-obtained livers suitable for use in perfusion research?
Journal of International Medical Research, 2023 Objectives The success of the ex vivo machine perfusion of pig livers used for preclinical research depends on organ quality and availability. In this study, we investigated whether livers obtained from slaughterhouses are suitable and equivalent to ...
Alicia Ruppelt +8 more
doaj +1 more source
Evaluation of Non-Invasive Sampling Methods for Detection of Hepatitis E Virus Infected Pigs in Pens
Microorganisms, 2023 Pigs are a reservoir of hepatitis E virus (HEV), which causes hepatitis in humans. To study the epidemiology of HEV in pig farms, sampling methods are currently used that cause discomfort to pigs, such as rectal sampling.
Marina Meester +6 more
doaj +1 more source