Results 41 to 50 of about 2,830 (156)

A Combined Therapy of Brassica Rapa L. Polysaccharides and Dexamethasone in Regulation of Rheumatoid Arthritis and Gut Microbiome

open access: yesFood Frontiers, Volume 6, Issue 6, Page 3024-3041, November 2025.
This study explored a combined therapy of Brassica rapa L. polysaccharides and dexamethasone with an improved anti‐rheumatic and immunomodulatory effects, which also altered gut microbiome and gut barrier disruption in regulation of rheumatoid arthritis.
Hongkang Zhu   +3 more
wiley   +1 more source

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

open access: yesAmerican Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel   +2 more
wiley   +1 more source

Improved Mixing Properties of Stirred Fermentation of an Aspergillus oryzae Hyphal Dispersion Mutant

open access: yesBiotechnology and Bioengineering, Volume 122, Issue 9, Page 2389-2399, September 2025.
ABSTRACT The complexity of mechanical and biological processes in filamentous fungal fermentation remains a major obstacle to improving product yield. We previously demonstrated that the AGΔ‐GAGΔ strain of Aspergillus oryzae, lacking both α‐1,3‐glucan (AG) and galactosaminogalactan (GAG), had improved hyphal dispersion, reduced culture viscosity, and ...
Shunya Susukida   +7 more
wiley   +1 more source

High frequency of known copy number abnormalities and maternal duplication 15q11-q13 in patients with combined schizophrenia and epilepsy [PDF]

open access: yes, 2011
Background Many copy number variants (CNVs) are documented to be associated with neuropsychiatric disorders, including intellectual disability, autism, epilepsy, schizophrenia, and bipolar disorder.
Larissa R Stewart   +4 more
core   +1 more source

Adaptive Tolerance of Listeria monocytogenes to Chemical Oxidants: Comparative Analysis of Transcriptomic Studies

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 5, September 2025.
ABSTRACT Listeria monocytogenes is a foodborne pathogen that poses significant challenges to food safety and public health due to its ability to adapt to harsh environments, particularly those found in food processing facilities. This review explores the global transcriptional responses of L.
Nagendran Rajalingam, Sam Van Haute
wiley   +1 more source

Diagnostic and prognostic potential of biomarkers in femoroacetabular impingement syndrome: A systematic review

open access: yesJournal of Experimental Orthopaedics, Volume 12, Issue 3, July 2025.
Abstract Purpose Early diagnosis of femoroacetabular impingement syndrome (FAIS) is essential. This systematic review aimed to identify biomarkers useful for diagnosing FAIS and predicting its progression to hip osteoarthritis. Our hypothesis was that there are biomarkers that are useful for the diagnosis and/or prognosis of FAIS.
Junya Yoshitani   +4 more
wiley   +1 more source

Redirecting Intermediary Metabolism to Counteract Cyanide Poisoning

open access: yesThe FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Cyanide is coined “the classic metabolic poison”; however, FDA‐approved cyanide chelators do not counteract cyanide's metabolic damage. Here, we review the mechanisms of cyanide toxicity, with a focus on intermediary metabolism. We present the theory that, within the innate plasticity of the metabolome, there may reside metabolic pathways that can ...
Vik S. Bebarta, Anjali K. Nath
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

open access: yes, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,   +11 more
core   +15 more sources

Innovative Oat‐Based Postbiotic and Synbiotic Products: Chemical Constituents and Hepatoprotective Efficacy

open access: yeseFood, Volume 6, Issue 3, June 2025.
ABSTRACT Oat (Avena sativa) is a health‐promoting food exhibiting prebiotic properties. We invented oat‐based postbiotics (Oat_PB) fermented with probiotics (mainly Lactobacillus and Bifidobacterium) and comprehensively compared their chemical constitutions with the synbiotic form (Oat_SB).
Ruixue Wen   +6 more
wiley   +1 more source

Identifying Cancer Specific Metabolic Signatures Using Constraint-Based Models [PDF]

open access: yes, 2016
Cancer metabolism differs remarkably from the metabolism of healthy surrounding tissues, and it is extremely heterogeneous across cancer types. While these metabolic differences provide promising avenues for cancer treatments, much work remains to be ...
Hoff, F.W.   +6 more
core   +1 more source

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