Results 31 to 40 of about 2,830 (156)

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

iMetaOmics, Volume 3, Issue 1, March 2026.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia, Likun Wang, Yangzhuo Xu, Jiaqi Zhang, Zeyang Zhou, Libing Sun, Heng Li, Chungen Xing, Jialu Mao, Yina Liu, Fulin Yang, Ling Zhong, Jiancheng Xu, Xiaodong Yang, Zhemin Zhou   +14 more
wiley   +1 more source

Identification of metabolism pathways directly regulated by sigma54 factor in Bacillus thuringiensis [PDF]

, 2015
Sigma54 (σ54) normally regulates nitrogen and carbon utilization in bacteria. Promoters that are σ54-dependent are highly conserved and contain short sequences located at the −24 and −12 positions upstream of the transcription initiation site.
Fuping Song, Guannan Wang, Guiming Liu, Jie Zhang, Qi Peng   +4 more
core   +2 more sources

Differences in Phenylpropanoid and Reactive Oxygen Species Genes Drive Plastic and Adaptive Responses to Drought Stress Between Douglas‐Fir Varieties and Hybrids

Plant Direct, Volume 10, Issue 3, March 2026.
ABSTRACT Warming climates bring significant challenges to the survival and growth of conifer species, yet the genomic basis of drought resistance is poorly understood. In this study, we used a common garden experiment to combine genomic, physiological and transcriptomic analysis to dissect plastic and adaptive responses to drought between Douglas‐fir ...
Kailey Baesen, Amanda Fitzhugh, Amanda R. De La Torre   +2 more
wiley   +1 more source

Which way does the citric acid cycle turn during hypoxia? The critical role of alpha-ketoglutarate dehydrogenase complex [PDF]

, 2013
The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not ...
Chinopoulos Christos
core   +1 more source

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis Wever, Brechtje de Jong, Marc T. C. van der Meij, Marielle van der Peet, Amy C. Harms, Thomas Hankemeier, Dick F. Swaab, Inge Huitinga, Joost Verhaagen, Mario van der Stelt   +12 more
wiley   +1 more source

Proteomic Analysis of Anti-Cancerous Scopularide Production by a Marine Microascus brevicaulis Strain and Its UV Mutant [PDF]

, 2015
The marine fungus Microascus brevicaulis strain LF580 is a non-model secondary metabolite producer with high yields of the two secondary metabolites scopularides A and B, which exhibit distinct activities against tumour cell lines.
Beck, Hans Christian, Imhoff, Johannes F., Kramer, Annemarie, Kristensen, Lars Peter, Kumar, Abhishek, Labes, Antje   +5 more
core   +3 more sources

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson, Lu Xia, Haiming Kerr, Marin Cabrera, Fabien Chu, Jaqueline Rose, Peter C. Wu, Atreya Dash, Sina A. Gharib, Jose M. Garcia   +9 more
wiley   +1 more source

Activating glutamate decarboxylase activity by removing the autoinhibitory domain leads to hyper γ-aminobutyric acid (GABA) accumulation in tomato fruit [PDF]

, 2017
γ-Aminobutyric acid (GABA) is a ubiquitous non-protein amino acid with several health-promoting benefits. In many plants including tomato, GABA is synthesized via decarboxylation of glutamate in a reaction catalyzed by glutamate decarboxylase (GAD ...
Ariizumi Tohru, Ezura Hiroshi, Matsukura Chiaki, Takayama Mariko, 千昭 千昭, 有泉 亨, 江面 浩   +6 more
core   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis [PDF]

, 2014
Synaptic transmission between midbrain dopamine neurons and target neurons in the striatum is essential for the selection and reinforcement of movements. Recent evidence indicates that nigrostriatal dopamine neurons inhibit striatal projection neurons by
Gu, Chenghua, Oh, Won-Jong, Sabatini, Bernardo L, Tritsch, Nicolas X   +3 more
core   +1 more source