Results 11 to 20 of about 1,586 (109)

Purification and partial characterisation of 4‐aminobutyrate 2‐ketoglutarate transaminase from human brain [PDF]

FEBS Letters, 1974
A parallelism has been shown between the anticonvulsive effect and an increase in the cerebral GABA level after in vivo administration of some branched chain fatty acids such as n-dipropylacetate [ 1,2] . It has also been shown that these compounds improve conditioned behaviour [3] .
Cash, C., Maitre, M., Ciesielski, L., Mandel, P.   +3 more
openaire   +2 more sources

Purification and Studies on Some Properties of the 4‐Aminobutyrate: 2‐Oxoglutarate Transaminase from Rat Brain [PDF]

European Journal of Biochemistry, 1975
Using various chromatographic procedures, 4‐aminobutyrate: 2‐oxoglutarate transaminase from rat brain has been purified 2400 times with respect to the initial brain homogenate. The purified protein, which has a specific activity of 10 μmol × min−1× mg−1, gave a single band by acrylamide gel electrophoresis and isoelectric focusing.
M, Maître, L, Ciesielski, C, Cash, P, Mandel   +3 more
openaire   +2 more sources

4‐Aminobutyrate aminotransferase (GABA‐transaminase) deficiency

Journal of Inherited Metabolic Disease, 1999
Abstract4‐Aminobutyrate aminotransferase (GABA‐transaminase, GABA‐T, EC 2.6.1.19) deficiency (McKusick 137150), an inborn error of GABA degradation, has until now been documented in only a single Flemish child. Compared to the other defects of GABA degradation, succinic semialdehyde dehydrogenase (SSADH, EC 1.2.1.24) deficiency with >150 patients ...
Medina-Kauwe, L.K., Tobin, A.J., De Meirleir, L., Jaeken, J., Jakobs, C.A.J.M., Nyhan, W.L., Gibson, K.M.   +6 more
openaire   +2 more sources

Microbial influences on immune modulation and colorectal cancer progression through combined transcriptomic and microbiomic analysis

iMetaOmics, Volume 3, Issue 1, March 2026.
Schematic representation of the distinct tumor microenvironment characteristics in CA1 and CA2 subtypes. CA1 illustrates an immune‐active tumor microenvironment characterized by elevated infiltration of immune cells, particularly CD8 + T cells and macrophages, and enhanced IFN‐γ signaling.
Shuting Xia, Likun Wang, Yangzhuo Xu, Jiaqi Zhang, Zeyang Zhou, Libing Sun, Heng Li, Chungen Xing, Jialu Mao, Yina Liu, Fulin Yang, Ling Zhong, Jiancheng Xu, Xiaodong Yang, Zhemin Zhou   +14 more
wiley   +1 more source

Differences in Phenylpropanoid and Reactive Oxygen Species Genes Drive Plastic and Adaptive Responses to Drought Stress Between Douglas‐Fir Varieties and Hybrids

Plant Direct, Volume 10, Issue 3, March 2026.
ABSTRACT Warming climates bring significant challenges to the survival and growth of conifer species, yet the genomic basis of drought resistance is poorly understood. In this study, we used a common garden experiment to combine genomic, physiological and transcriptomic analysis to dissect plastic and adaptive responses to drought between Douglas‐fir ...
Kailey Baesen, Amanda Fitzhugh, Amanda R. De La Torre   +2 more
wiley   +1 more source

Reduced triacylglycerols and lipid droplets are associated with resilience to Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Although it has become clear that alterations in lipid metabolism are associated with Alzheimer's disease (AD), it is unclear how they contribute to both cognitive decline and the pathophysiology of AD. METHODS Lipidomics and activity‐based protein profiling (ABPP) were performed in the frontal cortex of control, AD and resilient ...
Daan van der Vliet, Luuk E. de Vries, Xinyu Di, Dennis Wever, Brechtje de Jong, Marc T. C. van der Meij, Marielle van der Peet, Amy C. Harms, Thomas Hankemeier, Dick F. Swaab, Inge Huitinga, Joost Verhaagen, Mario van der Stelt   +12 more
wiley   +1 more source

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson, Lu Xia, Haiming Kerr, Marin Cabrera, Fabien Chu, Jaqueline Rose, Peter C. Wu, Atreya Dash, Sina A. Gharib, Jose M. Garcia   +9 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

A Combined Therapy of Brassica Rapa L. Polysaccharides and Dexamethasone in Regulation of Rheumatoid Arthritis and Gut Microbiome

Food Frontiers, Volume 6, Issue 6, Page 3024-3041, November 2025.
This study explored a combined therapy of Brassica rapa L. polysaccharides and dexamethasone with an improved anti‐rheumatic and immunomodulatory effects, which also altered gut microbiome and gut barrier disruption in regulation of rheumatoid arthritis.
Hongkang Zhu, He Qian, Zhenquan Yang, Yu Liu   +3 more
wiley   +1 more source

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel, Julie McLaughlin, Marta Frigeni   +2 more
wiley   +1 more source