Results 11 to 20 of about 2,830 (156)

In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase

Arabian Journal of Chemistry, 2017
AbstractReduced levels of γ-aminobutyric acid (GABA) are cause of quite a many diseases, and it cannot be directly introduced into the body to enhance its level because of the blood–brain barrier. Thus the technique used for the purpose involves the inhibition of aminobutyrate transaminase (ABAT), the enzyme catalyzing its degradation. The structure of
Iftikhar, Hira, Batool, Sidra, Deep, Aakash, Narasimhan, Balasubramanian, Sharma, Prabodh Chander, Malhotra, Manav   +5 more
openaire   +3 more sources

4‐Aminobutyrate aminotransferase (GABA‐transaminase) deficiency

Journal of Inherited Metabolic Disease, 1999
Abstract4‐Aminobutyrate aminotransferase (GABA‐transaminase, GABA‐T, EC 2.6.1.19) deficiency (McKusick 137150), an inborn error of GABA degradation, has until now been documented in only a single Flemish child. Compared to the other defects of GABA degradation, succinic semialdehyde dehydrogenase (SSADH, EC 1.2.1.24) deficiency with >150 patients ...
Medina-Kauwe, L.K., Tobin, A.J., De Meirleir, L., Jaeken, J., Jakobs, C.A.J.M., Nyhan, W.L., Gibson, K.M.   +6 more
openaire   +5 more sources

Transaminase and Norcoclaurine Synthase One-Pot Cascades Towards (1S)-Tetrahydroisoquinolines. [PDF]

Chembiochem
A TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Zhao J, Ni Y, Wang Y, Ward JM, Jeffries JWE, Hailes HC.   +5 more
europepmc   +2 more sources

Multi-omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer. [PDF]

Quant Biol
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Tanıl E, Nikerel E.
europepmc   +2 more sources

Suppression of γ-Aminobutyric Acid (GABA) Transaminases Induces Prominent GABA Accumulation, Dwarfism and Infertility in the Tomato (Solanum lycopersicum L.) [PDF]

, 2013
Tomatoes accumulate γ-aminobutyric acid (GABA) at high levels in the immature fruits. GABA is rapidly converted to succinate during fruit ripening through the activities of GABA transaminase (GABA-T) and succinate semialdehyde dehydrogenase (SSADH ...
Asamizu Erika, Ezura Hiroshi, Koike Satoshi, Matsukura Chiaki, Takayama Mariko, 千昭 千昭, 江面 浩   +6 more
core   +1 more source

Gamma‐aminobutyric acid transaminase genetic polymorphism is a candidate locus for responsiveness to opioid analgesics in patients with cancer pain: An exploratory study

Neuropsychopharmacology Reports, 2018
Aim Cancer pain impairs not only physical functions but also social functions and roles. Consequently, the overall health‐related quality of life of patients with cancer pain deteriorates. Opioid analgesics are recommended for treating moderate to strong
Yaeko Yokoshima, Masahiko Sumitani, Daisuke Nishizawa, Makoto Nagashima, Kazutaka Ikeda, Ryoji Kato, Jun Hozumi, Hiroaki Abe, Kenji Azuma, Rikuhei Tsuchida, Yoshitsugu Yamada, Japanese TR‐Cancer Pain Research Group   +11 more
doaj   +1 more source

Phenotyping GABA transaminase deficiency: a case description and literature review [PDF]

, 2016
Gamma-aminobutyric acid transaminase (GABA-T) deficiency is an autosomal recessive disorder reported in only three unrelated families. It is caused by mutations in the ABAT gene, which encodes 4-aminobutyrate transaminase, an enzyme of GABA catabolism ...
A Besse, A Pop, Alexandra Dinis, Ana Pop, Conceição Robalo, Cândida Cancelinha, Gajja S. Salomons, J Jaeken, J Jaeken, Lina Ramos, LM Levy, Luísa Diogo, M Tsuji, MN Ritta, Olinda Rebelo, Paula Garcia, Pedro Louro, Raquel Pina, Ricardo Veiga   +18 more
core   +2 more sources

Catalytic Promiscuity of Transaminases : Preparation of Enantioenriched β-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination [PDF]

, 2016
Transaminases are valuable enzymes for industrial biocatalysis and enable the preparation of optically pure amines. For these transformations they require either an amine donor (amination of ketones) or an amine acceptor (deamination of racemic amines ...
Ahrens, Amadasi, Baas, Bornscheuer, Borzęcka, Busto, Coelho, Coelho, Douvris, Fuchs, Goldberg, Hailes, Hammer, Hult, Humble, Höhne, Iwasaki, Kaulmann, Kazlauskas, Kazlauskas, Kittl, Koszelewski, Koszelewski, Kwan, Malik, Mathew, Mizuguchi, Mutti, Mutti, Nanavati, Peng, Pozzo, Pressnitz, Purser, Roiban, Savile, Shin, Silverman, Silverman, Silverman, Simon, Simon, Storici, Truppo, Tufvesson, Whittlesey, Zhu, Zizhan   +47 more
core   +3 more sources

Computational prediction and experimental verification of the gene encoding the NAD � /NADP � - dependent succinate semialdehyde dehydrogenase in Escherichia coli [PDF]

, 2007
Although NAD -dependent succinate semialdehyde dehydrogenase activity was first described in Escherichia coli more than 25 years ago, the responsible gene has remained elusive so far.
Dennis Vitkup, Lifeng Chen, Tobias Fuhrer, Uwe Sauer   +3 more
core   +2 more sources

Off-the-Vine Ripening of Tomato Fruit Causes Alteration in the Primary Metabolite Composition [PDF]

, 2013
The influence of postharvest fruit ripening in the composition of metabolites, transcripts and enzymes in tomato (Solanum lycopersicum L.) is poorly understood.
Abriata, Luciano Andres, Boggio, Silvana Beatriz, Sorrequieta, Augusto, Valle, Estela Marta   +3 more
core   +3 more sources