Results 1 to 10 of about 1,586 (109)
Transaminase and Norcoclaurine Synthase One-Pot Cascades Towards (1S)-Tetrahydroisoquinolines. [PDF]
ChembiochemA TAm‐NCS cascade towards THIQs has been established, starting from amines with the in situ production of aldehydes. The cascade was used with a variety of nonfunctionalized and functionalized amines, and reaction conditions modified to enhance formation of the desired cross‐products.
Zhao J +5 more
europepmc +2 more sources
Multi-omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer. [PDF]
Quant BiolAbstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Tanıl E, Nikerel E.
europepmc +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Many studies have focussed on modulating the activity of γ-aminobutyric acid transaminase (GABA-T), a GABA-catabolizing enzyme, for treating neurological diseases, such as epilepsy and drug addiction. Nevertheless, human GABA-T synthesis and purification
Mingu Gordon Park +5 more
doaj +1 more source
Scientific Reports, 2023 Lactic acid bacteria produce γ-aminobutyric acid (GABA) as an acid stress response. GABA is a neurotransmitter that may improve sleep and resilience to mental stress.
Ateequr Rehman +8 more
doaj +1 more source
RNA Biology, 2023 The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen +4 more
doaj +1 more source
Frontiers in Neuroscience, 2019 Broad-scale untargeted biochemical phenotyping is a technology that supplements widely accepted assays, such as organic acid, amino acid, and acylcarnitine analyses typically utilized for the diagnosis of inborn errors of metabolism.
Adam D. Kennedy +13 more
doaj +1 more source
Neuropsychopharmacology Reports, 2018 Aim Cancer pain impairs not only physical functions but also social functions and roles. Consequently, the overall health‐related quality of life of patients with cancer pain deteriorates. Opioid analgesics are recommended for treating moderate to strong
Yaeko Yokoshima +11 more
doaj +1 more source
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
Abunmix enables the simple and robust multiplexed immunofluorescence imaging
VIEW, Volume 7, Issue 3, June 2026.Multiplexed fluorescence imaging is limited by bleed‐through signals arising from the use of antibodies derived from the same host species. Abunmix can separate signals from multiple antibodies generated from the same host species using a signal unmixing algorithm.
Woonggi La +14 more
wiley +1 more source
Blood‐Based Epigenetic Signatures in Brazilian Males With Alcohol Use Disorder
Addiction Biology, Volume 31, Issue 5, May 2026.This study represents the first epigenome‐wide association analysis of Alcohol Use Disorder (AUD) in a genetically and culturally diverse Brazilian cohort. Genome‐wide DNA methylation profiling revealed hypomethylation in genes and pathways related to neuronal development, synaptic organization, intracellular signaling and cellular stress responses in ...
Laís da Silva Pereira‐Rufino +15 more
wiley +1 more source