Results 1 to 10 of about 2,830 (156)
Intramitochondrial localization of the 4-aminobutyrate-2-oxoglutarate transaminase from ox brain [PDF]
Biochemical Journal, 1977 In order to determne the intramitochondrial location of 4-aminobutyrate transaminase, mitochondria were prepared from ox brain and freed from myelin and synaptosomes by using conventional density-gradient-centrifugation techniques, and the purity was checked electron-microscopically.
I, Schousboe, B, Bro, A, Schousboe
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Purification and Studies on Some Properties of the 4‐Aminobutyrate: 2‐Oxoglutarate Transaminase from Rat Brain [PDF]
European Journal of Biochemistry, 1975 Using various chromatographic procedures, 4‐aminobutyrate: 2‐oxoglutarate transaminase from rat brain has been purified 2400 times with respect to the initial brain homogenate. The purified protein, which has a specific activity of 10 μmol × min−1× mg−1, gave a single band by acrylamide gel electrophoresis and isoelectric focusing.
M, Maître +3 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Many studies have focussed on modulating the activity of γ-aminobutyric acid transaminase (GABA-T), a GABA-catabolizing enzyme, for treating neurological diseases, such as epilepsy and drug addiction. Nevertheless, human GABA-T synthesis and purification
Mingu Gordon Park +5 more
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Scientific Reports, 2023 Lactic acid bacteria produce γ-aminobutyric acid (GABA) as an acid stress response. GABA is a neurotransmitter that may improve sleep and resilience to mental stress.
Ateequr Rehman +8 more
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RNA Biology, 2023 The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen +4 more
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Label-free shotgun proteomics and metabolite analysis reveal a significant metabolic shift during citrus fruit development. [PDF]
, 2011 Label-free LC-MS/MS-based shot-gun proteomics was used to quantify the differential protein synthesis and metabolite profiling in order to assess metabolic changes during the development of citrus fruits.
Blumwald, Eduardo +8 more
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Purification and partial characterisation of 4‐aminobutyrate 2‐ketoglutarate transaminase from human brain [PDF]
FEBS Letters, 1974 A parallelism has been shown between the anticonvulsive effect and an increase in the cerebral GABA level after in vivo administration of some branched chain fatty acids such as n-dipropylacetate [ 1,2] . It has also been shown that these compounds improve conditioned behaviour [3] .
Cash, C. +3 more
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Frontiers in Neuroscience, 2019 Broad-scale untargeted biochemical phenotyping is a technology that supplements widely accepted assays, such as organic acid, amino acid, and acylcarnitine analyses typically utilized for the diagnosis of inborn errors of metabolism.
Adam D. Kennedy +13 more
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Characterising the role of GABA and its metabolism in the wheat pathogen Stagonospora nodorum [PDF]
, 2015 A reverse genetics approach was used to investigate the role of γ-aminobutyric acid metabolism in the wheat pathogenic fungus Stagonospora nodorum. The creation of mutants lacking Sdh1, the gene encoding succinic semialdehyde dehydrogenase, resulted in ...
Mead, Oliver +3 more
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Genes of different catabolic pathways are coordinately regulated by Dal81 in Saccharomyces cerevisiae [PDF]
, 2015 Yeast can use a wide variety of nitrogen compounds. However, the ability to synthesize enzymes and permeases for catabolism of poor nitrogen sources is limited in the presence of a rich one.
Bermudez Moretti, Mariana +2 more
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