Results 91 to 100 of about 21,834 (203)

On the dilemma of fractal or fractional kinetics in drug release studies: A comparison between Weibull and Mittag-Leffler functions

, 2018
We compare two of the most successful models for the description and analysis of drug release data. The fractal kinetics approach leading to release profiles described by a Weibull function and the fractional kinetics approach leading to release profiles
Kosmidis, Kosmas, Macheras, Panos
core   +1 more source

Proceedings of Abstracts Engineering and Computer Science Research Conference 2019 [PDF]

, 2019
© 2019 The Author(s). This is an open-access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Adams, Roderick, Amafabia, Daerefa-a, Barker, Trevor, Beka, Nathan, Bhavsar, Ronakben, Bonivart, Agnes, Canoville, Paul, Cañamero, Lola, CHEN, Yong Kang, CHEN, Yong Kang, Chrysanthou, Andreas, Counsell, Nathan, Crook, Brian, Davey, Neil, David-West, Opukuro, Denai, Mouloud, Dhakal, Hom, Drix, Damien, Goncharenko, Julia, Grasso, Marzio, Hafner, Verena Vanessa, Hall, Samantha, Haritos, George, Hassan, Eheda, Helian, Na, Herfatmanesh, Mohammad Reza, Ismail, Sikiru O., Johnston, Ian, Johnston, Ian, Kadir, Shabnam, Kaye, Richard, Khan, Imran, Kirner, Raimund, Kirner, Raimund, Klaholz, Ingo, Klusak, Jan, Kourtessis, Pandelis, Lane, Peter, Lekkala, Himayasri Rao, Lilley, Mariana, Mayor, David, McCluskey, Daniel, McCluskey, Daniel, Menon, Catherine, Metzner, Christoph, Miko, Rebecca, Montalvão, Diogo, Mporas, Iosif, Munro, Ian, Nehaniv, Chrystopher, Newman, James, Nwawe, Richard, Panday, Deepak, Partou, Helen, Pissanidis, Georgios, Polani, Daniel, Ren, Guogang, Robinson, Matthew, Rosiello, Vincenzo, Sayers, Paul, Schilstra, Maria, Schirmer, Pascal, Schmuker, Michael, Siadati, Rana, Sinha, Ankur, Skaltsas, Grigorios, Steffert, Tony, Steuber, Volker, Steuber, Volker, Suckow, Bjorn, Sun, Yi, Sun, Yichuang, Sunmola, Funlade, Sutton, Samuel, te Boekhorst, Rene, Toffe, Gilles, Tracey, Mark, Tveretina, Olga, Veneziano, Vito, Verma, Alok, Wang, Yuan, Wernick, Paul   +81 more
core   +2 more sources

The sympathoregulatory region of the mouse rostral brainstem relies on both GABA and glycine to generate inhibitory currents

The Journal of Physiology, EarlyView.
Abstract figure legend Our study demonstrates that both GABA and glycine mediate inhibitory postsynaptic currents in the ventrolateral/ventromedial medulla (VLM/VMM) and increasing the activity of inhibitory synapses facilitates glycine release. We found that presympathetic VLM/VMM neurons receive glycinergic inputs, which release both glycine and GABA,
Hong Gao, Lucie D. Desmoulins, Adrien J. R. Molinas, Courtney M. Dugas, Andrea Zsombok, Andrei V. Derbenev   +5 more
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

Exclusion of CLIC5 as a Candidate Gene and Identification of NEFM as a Possible Novel Gene Correlated With Autosomal Recessive Pure Cerebellar Ataxia in a Highly Consanguineous Family

Molecular Genetics &Genomic Medicine, Volume 14, Issue 4, April 2026.
Whole‐exome sequencing candidate CLIC5 and NEFM for cerebellar ataxia (CA) onset. In vivo studies exclude CLIC5, while in silico analysis and literature review support NEFM as a candidate gene for CA. These findings could be useful for advancing the genetic diagnosis of hereditary pure CA. Created in https://BioRender.com.
Paolo Enrico Maltese, Gabriele Bonetti, Elena Manara, Benedetta Tanzi, Andrea Bernini, Mark A. Berryman, Soichi Tanda, Corinne Nielsen, Silvia Casagrande, Amanda Ferrero, Salvatore Stano, Riccardo Zuccarino, Andrea Barp, Pietro Chiurazzi, Matteo Bertelli   +14 more
wiley   +1 more source

Developmental features of 4-aminopyridine induced epileptogenesis

Developmental Brain Research, 1996
4-Aminopyridine (4-AP, 50 microM), perfused in rat hippocampal slices from postnatal days 2-30 (P2-P30), induced in the CA3 area the appearance of spontaneous epileptiform discharges, short (interictal-like) and sustained (ictal-like), as well as slow potential.
Psarropoulou, C., Avoli, M.
openaire   +3 more sources

Feasibility of combination allogeneic stem cell therapy for spinal cord injury: a case report [PDF]

, 2010
Cellular therapy for spinal cord injury (SCI) is overviewed focusing on bone marrow mononuclear cells, olfactory ensheathing cells, and mesenchymal stem cells. A case is made for the possibility of combining cell types, as well as for allogeneic use.
Thomas E Ichim, Fabio Solano, Fabian Lara, Eugenia Paris, Federico Ugalde, Jorge Rodriguez, Boris Minev, Vladimir Bogin, Famela Ramos, Erik J Woods, Michael P Murphy, Amit N Patel, Robert J Harman, Neil H Riordan   +13 more
core   +1 more source

Recent Advances in Chemical Probing Strategies for RNA Structure Determination In Vivo

Chemistry – A European Journal, Volume 32, Issue 12, 23 March 2026.
This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova, Jieyu Zhao, Chun Kit Kwok   +2 more
wiley   +1 more source

Assembling an isomer grid: the isomorphous 4-, 3- and 2-fluoro-N'-(4-pyridyl)benzamides [PDF]

, 2008
The three title isomers, 4-, (I), 3-, (II), and 2-fluoro-N'-(4-pyridyl)benzamide, (III), all C₁₂H₉FN₂O, crystallize in the P21/c space group (No. 14) with similar unit-cell parameters and are isomorphous and isostructural at the primary hydrogen-bonding ...
Donnelly, Katie, Gallagher, John F., Lough, Alan J.   +2 more
core   +1 more source

Diclofenac Prolongs Repolarization in Ventricular Muscle with Impaired Repolarization Reserve [PDF]

, 2012
Background: The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti- inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle.
A Farkas, A Peretz, A Varró, A Varró, A Varró, AJ Batey, Andrea Barbuti, András Varró, Attila Kristóf, B Girennavar, B Scheidel, C Bombardier, C Lengyel, C Lengyel, CL Lawrence, Cs Lengyel, D Corrado, DM Roden, DM Roden, DM Roden, E Coraboeuf, EL Fosbøl, FI Al-Jenoobi, G Hart, HA Bird, István Baczkó, István Koncz, JH Lin, JJ Duncan, Julius Gy Papp, L Carlsson, L Virág, LI Brueggemann, LL von Moltke, LY Liu, László Virág, M Hidaka, M Niemi, MA Vos, N Jost, Norbert Jost, OV Yarishkin, P McGettigan, PG Volders, Péter Biliczki, R Bort, R Varkevisser, S Trelle, T Christ, Tamás Szél, Viktor Juhász, WF Huang, WF Huang, XW Fei, Y Lu, Zoltán Husti, Zsófia Kohajda   +56 more
core   +2 more sources