Results 81 to 90 of about 13,554 (179)

Potentiation of neostigmine and pyridostigmine by 4-aminopyridine in the rat

Journal of Pharmacy and Pharmacology, 1978
AbstractThe interaction between 4-aminopyridine and neostigmine or pyridostigmine was studied in vivo in the rat sciatic nerve-anterior tibialis preparation using the constant infusion of pancuronium technique. The ED50 (dose of drug which produced a 50% antagonism) of neostigmine, pyridostigmine and 4-aminopyridine were 18, 49 and 440 μg kg−1 ...
Miller, RD, Dennissen, PAF, van der Pol, F, Agoston, S, Booij, LHDJ, Crul, JF   +5 more
openaire   +3 more sources

Suppression of Inflammatory Demyelinaton and Axon Degeneration through Inhibiting Kv3 Channels

Frontiers in Molecular Neuroscience, 2017
The development of neuroprotective and repair strategies for treating progressive multiple sclerosis (MS) requires new insights into axonal injury. 4-aminopyridine (4-AP), a blocker of voltage-gated K+ (Kv) channels, is used in symptomatic treatment of ...
Peter Jukkola, Yuanzheng Gu, Amy E. Lovett-Racke, Chen Gu, Chen Gu   +4 more
doaj   +1 more source

Synthesis, Characterization and Antibacterial Properties of Complex [Ag(SCN)(2-NH2py)] [PDF]

E3S Web of Conferences
The reaction of AgSCN with 2-aminopyridine in ammonia solution produces the colorless crystal of catena-poly [Ag(SCN))(C6H5N2)]n. The crystals were characterized by FTIR analysis and single crystal X-Ray diffraction.
Mariyam Dewi, Dasna I. Wayan, Wijaya Husni Wahyu, Danar   +3 more
doaj   +1 more source

Modeling seizure networks in neuron-glia cultures using microelectrode arrays

Frontiers in Network Physiology
Epilepsy is a common neurological disorder, affecting over 65 million people worldwide. Unfortunately, despite resective surgery, over 30% of patients with drug-resistant epilepsy continue to experience seizures.
Ujwal Boddeti, Ujwal Boddeti, Jenna Langbein, Darrian McAfee, Marcelle Altshuler, Muzna Bachani, Hitten P. Zaveri, Dennis Spencer, Kareem A. Zaghloul, Alexander Ksendzovsky   +9 more
doaj   +1 more source

GABA_B receptor outward currents are transiently disclosed by the convulsant 4-aminopyridine in vitro. [PDF]

Curr Res Neurobiol, 2023
Cattani A, Wang S, Lévesque M, Farmer JP, Dudley RWR, Avoli M.   +5 more
europepmc   +1 more source

In vivo laser speckle contrast imaging of 4-aminopyridine- or pentylenetetrazole-induced seizures. [PDF]

APL Bioeng, 2023
Wang Y, Tsytsarev V, Liao LD.
europepmc   +1 more source

Mechanism of 4-aminopyridine inhibition of the lysosomal channel TMEM175. [PDF]

Proc Natl Acad Sci U S A, 2022
Oh S, Stix R, Zhou W, Faraldo-Gómez JD, Hite RK.   +4 more
europepmc   +1 more source

Effects of 4-Aminopyridine on Combined Nerve and Muscle Injury and Bone Loss. [PDF]

J Hand Surg Am, 2023
Govindappa PK, Jagadeeshaprasad MG, Tortora P, Talukder MAH, Elfar JC.   +4 more
europepmc   +1 more source

4-Aminopyridine improves real-life gait performance in SCA27B on a single-subject level: a prospective n-of-1 treatment experience. [PDF]

J Neurol, 2023
Seemann J, Traschütz A, Ilg W, Synofzik M.   +3 more
europepmc   +1 more source

Involvement of GABAergic Interneuron Subtypes in 4-Aminopyridine-Induced Seizure-Like Events in Mouse Entorhinal Cortex in Vitro. [PDF]

J Neurosci, 2023
Scalmani P, Paterra R, Mantegazza M, Avoli M, de Curtis M.   +4 more
europepmc   +1 more source