Results 131 to 140 of about 13,717 (182)

Facile synthesis of functionalized 4-aminopyridines

Chemical Communications, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Nagatoshi, Nishiwaki, Mayumi, Azuma, Mina, Tamura, Kazushige, Hori, Yasuo, Tohda, Masahiro, Ariga   +5 more
openaire   +2 more sources

Effects of 4-aminopyridine on saxitoxin intoxication

Toxicology and Applied Pharmacology, 1996
Effects of 4-aminopyridine (4-AP) on neurotoxicity induced by saxitoxin (STX) are investigated in this study. In vitro, twitch tension evoked by nerve stimulation was depressed by STX (1.35 nM) in rat phrenic nerve-diaphragm preparations, and this inhibition was antagonized by 4-AP (0.1 mM).
H M, Chen, C H, Lin, T M, Wang
openaire   +2 more sources

Determination of 4-aminopyridine in plasma

Analytical Biochemistry, 1981
Abstract Gas-liquid chromatographic procedures for the determination of 4-aminopyridine in human and animal plasma are reported. The procedures involve the addition of an internal standard 3-methyl-4-aminopyridine to plasma followed by extraction into methylene chloride/isopropranol under alkaline conditions.
openaire   +2 more sources

4‐Aminopyridine in multiple sclerosis

Neurology, 1991
In an earlier study, we demonstrated efficacy of single oral doses of 4-aminopyridine (4-AP) in improving motor and visual signs in multiple sclerosis (MS) patients for a mean of 4.97 hours. We attempted to determine whether efficacy could safely be prolonged using multiple daily doses over several days by administering 7.5 to 52.5 mg 4-AP to 17 ...
D, Stefoski, F A, Davis, W E, Fitzsimmons, S S, Luskin, J, Rush, G W, Parkhurst   +5 more
openaire   +2 more sources

Action of 4-aminopyridine on the cerebral circulation

Acta Neurologica Scandinavica, 2009
4-Aminopyridine (4-AP) facilitates both inhibitory and excitatory synaptic activity in the central nervous system, and may, therefore, be a drug of potential therapeutic use in brain diseases with a disturbed synaptic transmission. In the present study the vasomotor effects upon isolated feline brain vessels, and regional cerebral blood flow and brain ...
L, Edvinsson, J E, Hardebo, H, Lundh
openaire   +2 more sources

4-Aminopyridine derivatives with antiamnesic activity

European Journal of Medicinal Chemistry, 2000
Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of
A, Andreani, A, Leoni, A, Locatelli, R, Morigi, M, Rambaldi, C, Pietra, G, Villetti   +6 more
openaire   +2 more sources

4-Aminopyridine in the treatment of alzheimer's disease

Biological Psychiatry, 1988
The cognitive and behavioral effect of 4-aminopyridine (4-AP) was examined in Alzheimer's disease (AD) using a dose finding/replication study design. Fourteen inpatients, aged 54-89 years (mean 66.1 +/- 10.6 SD), meeting NINCDS criteria for probable AD, were studied.
M, Davidson, Z, Zemishlany, R C, Mohs, T B, Horvath, P, Powchik, J P, Blass, K L, Davis   +6 more
openaire   +2 more sources

Pharmacokinetics of 4‐aminopyridine derivatives in dogs

Journal of Veterinary Pharmacology and Therapeutics, 2009
Blockade of potassium channels with 4‐aminopryidine (4‐AP) restores conduction to demyelinated axons and improves function. Unfortunately, 4‐AP causes adverse effects and its clinical effects are unpredictable and limited. Derivatives of 4‐AP have been tested in models of spinal cord injury in guinea pigs; three derivatives (methyl‐, ethyl‐ and t‐butyl
N J, Olby, D T, Smith, J, Humphrey, K, Spinapolice, N, Parke, P M, Mehta, D, Dise, M, Papich   +7 more
openaire   +2 more sources

Long-term potentiation and 4-aminopyridine

Cellular and Molecular Neurobiology, 1985
Long-term potentiation (LTP) of excitatory postsynaptic potentials (epsp's) was investigated with extracellular field potential recording in hippocampal slices from rats. In the presence of 100 microM 4-aminopyridine (4-AP) the probability of eliciting LTP was unchanged or increased; the extent of potentiation was not significantly different from ...
H L, Haas, R W, Greene
openaire   +2 more sources

The effect of 4-aminopyridine on acetylcholine release

Journal of Neural Transmission, 1977
The effect of 2-, and 4-aminopyridine (4-APYR) on the release mechanism of acetylcholine (ACh) from the nerve terminals of the Auerbach plexus-longitudinal muscle preparation of the guinea-pig ileum, suspended in eserinized Krebs' solution, was investigated. 2- and 4-APYR increased the release of ACh from the nerve terminals at rest and at both low and
E S, Vizi, J, van Dijk, F F, Foldes
openaire   +2 more sources