Results 131 to 140 of about 13,554 (179)

Pharmacokinetics of 4-aminopyridine in horses

American Journal of Veterinary Research, 1984
SUMMARY The pharmacokinetics of 4-aminopyridine (4-ap), a drug capable of antagonizing nondepolarizing neuromuscular blocking drugs, as well as several classes of injectable sedative and anesthetic agents, were studied in 6 intact, awake horses. Plasma samples were assayed for 4-ap over a frequent sampling schedule for 8 hours after iv administration ...
J V, Kitzman, R C, Wilson, N H, Booth, H L, Hendricks, P B, Bush   +4 more
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Pharmacokinetics of 4-aminopyridine in cattle

American Journal of Veterinary Research, 1984
SUMMARY Concentrations of 4-aminopyridine hydrochloride in plasma of cattle were measured over an 8-hour period following a bolus IV injection (0.3 mg/kg). The drug was assayed by a gas-liquid chromatographic method using a nitrogen-phosphorus detector.
J V, Kitzman, R C, Wilson, N H, Booth, J M, Zahner, H L, Hendricks, P B, Bush   +5 more
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Alkylation of 4-aminopyridine

Chemistry of Heterocyclic Compounds, 1971
4-Alkylaminopyridines are formed by the alkylation of 4-aminopyridine with cyclohexanol, cyclopentanol, and 2-propanol in sulfuric acid.
S. I. Burmistrov, A. V. Krasovskii
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Facile synthesis of functionalized 4-aminopyridines

Chemical Communications, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Nagatoshi, Nishiwaki, Mayumi, Azuma, Mina, Tamura, Kazushige, Hori, Yasuo, Tohda, Masahiro, Ariga   +5 more
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Effects of 4-aminopyridine on saxitoxin intoxication

Toxicology and Applied Pharmacology, 1996
Effects of 4-aminopyridine (4-AP) on neurotoxicity induced by saxitoxin (STX) are investigated in this study. In vitro, twitch tension evoked by nerve stimulation was depressed by STX (1.35 nM) in rat phrenic nerve-diaphragm preparations, and this inhibition was antagonized by 4-AP (0.1 mM).
H M, Chen, C H, Lin, T M, Wang
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Action of 4-aminopyridine on the cerebral circulation

Acta Neurologica Scandinavica, 2009
4-Aminopyridine (4-AP) facilitates both inhibitory and excitatory synaptic activity in the central nervous system, and may, therefore, be a drug of potential therapeutic use in brain diseases with a disturbed synaptic transmission. In the present study the vasomotor effects upon isolated feline brain vessels, and regional cerebral blood flow and brain ...
L, Edvinsson, J E, Hardebo, H, Lundh
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Determination of 4-aminopyridine in plasma

Analytical Biochemistry, 1981
Abstract Gas-liquid chromatographic procedures for the determination of 4-aminopyridine in human and animal plasma are reported. The procedures involve the addition of an internal standard 3-methyl-4-aminopyridine to plasma followed by extraction into methylene chloride/isopropranol under alkaline conditions.
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4-Aminopyridine derivatives with antiamnesic activity

European Journal of Medicinal Chemistry, 2000
Acetylcholine (Ach) enhancement, useful in the treatment of Alzheimer's disease (AD), may be obtained by means of ion channel modulators such as 4-aminopyridine (4-AP). 4-AP is also the central ring of tacrine, the first drug approved for the treatment of AD. The synthesis and pharmacological activity of three 4-AP derivatives, prepared with the aim of
A, Andreani, A, Leoni, A, Locatelli, R, Morigi, M, Rambaldi, C, Pietra, G, Villetti   +6 more
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4‐Aminopyridine in multiple sclerosis

Neurology, 1991
In an earlier study, we demonstrated efficacy of single oral doses of 4-aminopyridine (4-AP) in improving motor and visual signs in multiple sclerosis (MS) patients for a mean of 4.97 hours. We attempted to determine whether efficacy could safely be prolonged using multiple daily doses over several days by administering 7.5 to 52.5 mg 4-AP to 17 ...
D, Stefoski, F A, Davis, W E, Fitzsimmons, S S, Luskin, J, Rush, G W, Parkhurst   +5 more
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Pharmacokinetics of 4‐aminopyridine derivatives in dogs

Journal of Veterinary Pharmacology and Therapeutics, 2009
Blockade of potassium channels with 4‐aminopryidine (4‐AP) restores conduction to demyelinated axons and improves function. Unfortunately, 4‐AP causes adverse effects and its clinical effects are unpredictable and limited. Derivatives of 4‐AP have been tested in models of spinal cord injury in guinea pigs; three derivatives (methyl‐, ethyl‐ and t‐butyl
N J, Olby, D T, Smith, J, Humphrey, K, Spinapolice, N, Parke, P M, Mehta, D, Dise, M, Papich   +7 more
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