Results 141 to 150 of about 13,554 (179)
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4-Aminopyridine in the treatment of alzheimer's disease
Biological Psychiatry, 1988The cognitive and behavioral effect of 4-aminopyridine (4-AP) was examined in Alzheimer's disease (AD) using a dose finding/replication study design. Fourteen inpatients, aged 54-89 years (mean 66.1 +/- 10.6 SD), meeting NINCDS criteria for probable AD, were studied.
M, Davidson +6 more
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Long-term potentiation and 4-aminopyridine
Cellular and Molecular Neurobiology, 1985Long-term potentiation (LTP) of excitatory postsynaptic potentials (epsp's) was investigated with extracellular field potential recording in hippocampal slices from rats. In the presence of 100 microM 4-aminopyridine (4-AP) the probability of eliciting LTP was unchanged or increased; the extent of potentiation was not significantly different from ...
H L, Haas, R W, Greene
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The effect of 4-aminopyridine on acetylcholine release
Journal of Neural Transmission, 1977The effect of 2-, and 4-aminopyridine (4-APYR) on the release mechanism of acetylcholine (ACh) from the nerve terminals of the Auerbach plexus-longitudinal muscle preparation of the guinea-pig ileum, suspended in eserinized Krebs' solution, was investigated. 2- and 4-APYR increased the release of ACh from the nerve terminals at rest and at both low and
E S, Vizi, J, van Dijk, F F, Foldes
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An unusual case of 4-aminopyridine toxicity
The Journal of Emergency Medicine, 20064-aminopyridine (4-AP) is an orphan drug in the United States. It enhances neuronal conduction at synapses and is indicated in the treatment of selected neuromuscular disorders, including multiple sclerosis and myasthenia gravis, among others. Its documented toxicity generally has been limited to central nervous system (CNS) hyperexcitation and ...
Nicholas C, Johnson, Matthew W, Morgan
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Atypical Presentation of 4-Aminopyridine Overdose
Annals of Emergency Medicine, 19964-Aminopyridine (4-AP) is an investigational drug for the treatment of neurologic disorders including multiple sclerosis (MS). Until recently, relatively little was known about 4-AP toxicity in overdose; the only recorded cases involved neurologic symptoms ranging from mild parasthesias to tonic-clonic seizures.
T A, Pickett, R, Enns
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4-Aminopyridine and Haemodialysis in the Treatment of Verapamil Intoxication
Human Toxicology, 1985Verapamil, a calcium antagonist, is used as an antianginal, antidysrhythmic and antihypertensive agent. Fatal intoxications with this commonly used drug have been described. We report the effects of 4-aminopyridine and haemodialysis in a patient with severe verapamil intoxication.
TERWEE, PM +3 more
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4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity
Bioorganic & Medicinal Chemistry Letters, 2008Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase.
SCIPIONE, Luigi +5 more
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Distribution of the 4-aminopyridine derivative 3-methoxy-4-aminopyridime in mice
Neuropharmacology, 1989The tissue distribution of [14C]3-Methoxy-4-aminopyridine was studied after intravenous administration in mice using whole body and microautoradiography. Dense accumulation was found in cholinergically innervated, secretory organs. High radioactivity was detected in the adrenal medulla suggesting that the observed excitement and hyperglycemia are due ...
Berger SG, Waser PG, Chang Sin-Ren A
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Effects of 4-aminopyridine on neuromuscular transmission
Brain Research, 19784-Aminopyridine (4-AP) powerfully increases transmitter release from motor nerve terminals of rat and frog skeletal muscle in response to single nerve impulses. The drug also enhances transmitter release during repetitive nerve activity but, at D-tubocurarine-blocked endplates, only the first impulses cause increased transmitter release at stimulation ...
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