Results 121 to 130 of about 13,717 (182)

Characterization of 4-Aminopyridine in Overdose

Journal of Toxicology: Clinical Toxicology, 1994
We report three cases of 4-aminopyridine overdose resulting in seizure activity. All patients were on therapeutic regimens for the treatment of multiple sclerosis. All patients were responsive to intensive supportive care, although the length of toxicity was prolonged more than 24 hours in one patient.

exaly   +3 more sources

4-Aminopyridine kinetics

Clinical Pharmacology and Therapeutics, 1982
Nine healthy subjects (7 men; 2 women) received single 20-mg IV injections of 4-aminopyridine (4-AP). Six of the subjects received the same dose in the form of enteric-coated tablets and four the same dose in uncoated tablets; treatments were at least 2 wk apart.
UGES, DRA, SOHN, YJ, GREIJDANUS, B, SCAF, AHJ, AGOSTON, S   +4 more
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Interaction of antidepressants with 4-aminopyridine

Life Sciences, 1992
Systemic administration of 4-Aminopyridine at a dose of 4 mg/kg (4-AP) induces hypothermia in mice. Scopolamine (ED50 = 0.26 mg/kg) and two tricyclic antidepressants, desipramine (ED50 = 1.82 mg/kg) and IM/P/3/4 (ED50 = 8.95 mg/kg) completely antagonize 4-AP-induced hypothermia, whereas minaprine (0.1-0.25 mg/kg), a non-tricyclic antidepressant ...
G, Volterra, A, Lecci
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An Electroencephalographic Study of 4-Aminopyridine

Anesthesia & Analgesia, 1982
The electroencephalographic (EEG) effects of 4-aminopyridine (4-AP) given intravenously in therapeutic doses were studied in four conscious human volunteers. 4-AP (0.2 mg/kg) caused an increase of the occipital alpha peak frequency of 0.4 to 1.0 Hz. In the dose range of 0.2 to 0.3 mg/kg there was neither evidence for epileptic activity in the EEG nor ...
R L, Sia, S, Boonstra, P, Westra, H T, Haenen, H, Wesseling   +4 more
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INDO theoretical studies of 4-aminopyridine and protonated 4-aminopyridine

Journal of the Chemical Society, Perkin Transactions 2, 1975
Geometry optimized INDO calculations have been performed on 4-aminopyridine (2) and protonated 4-aminopyridine (1) in order to compare their optimized geometries, π-bond orders, C(4)–NH2 rotational barriers, charge densities, and π-electron distributions. It had previously been shown that 4-aminopyridine falls far off a linear correlation of ΔG° and ΔS°
Charles U. Pittman, Onallah M. Attallah, Lowell D. Kispert   +2 more
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Pharmacokinetics of 4-aminopyridine in cattle

American Journal of Veterinary Research, 1984
SUMMARY Concentrations of 4-aminopyridine hydrochloride in plasma of cattle were measured over an 8-hour period following a bolus IV injection (0.3 mg/kg). The drug was assayed by a gas-liquid chromatographic method using a nitrogen-phosphorus detector.
J V, Kitzman, R C, Wilson, N H, Booth, J M, Zahner, H L, Hendricks, P B, Bush   +5 more
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Pharmacokinetics of 4-aminopyridine in horses

American Journal of Veterinary Research, 1984
SUMMARY The pharmacokinetics of 4-aminopyridine (4-ap), a drug capable of antagonizing nondepolarizing neuromuscular blocking drugs, as well as several classes of injectable sedative and anesthetic agents, were studied in 6 intact, awake horses. Plasma samples were assayed for 4-ap over a frequent sampling schedule for 8 hours after iv administration ...
J V, Kitzman, R C, Wilson, N H, Booth, H L, Hendricks, P B, Bush   +4 more
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Alkylation of 4-aminopyridine

Chemistry of Heterocyclic Compounds, 1971
4-Alkylaminopyridines are formed by the alkylation of 4-aminopyridine with cyclohexanol, cyclopentanol, and 2-propanol in sulfuric acid.
S. I. Burmistrov, A. V. Krasovskii
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