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Synthesis of K<sup>+</sup> channel radioligand [<sup>18</sup>F]5-methyl-3-fluoro-4-aminopyridine and PET imaging in mice. [PDF]

open access: yesBioorg Med Chem Lett
Sun Y   +5 more
europepmc   +1 more source

Spinon Excitations in 99.9% Deuterated Single Crystals of Tomonaga-Luttinger Liquid [Cu(μ-C2O4)(4-Aminopyridine)2(H2O)] n. [PDF]

open access: yesACS Omega
Athira S   +9 more
europepmc   +1 more source
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4-Aminopyridine kinetics

Clinical Pharmacology and Therapeutics, 1982
Nine healthy subjects (7 men; 2 women) received single 20-mg IV injections of 4-aminopyridine (4-AP). Six of the subjects received the same dose in the form of enteric-coated tablets and four the same dose in uncoated tablets; treatments were at least 2 wk apart.
UGES, DRA   +4 more
openaire   +3 more sources

Interaction of antidepressants with 4-aminopyridine

Life Sciences, 1992
Systemic administration of 4-Aminopyridine at a dose of 4 mg/kg (4-AP) induces hypothermia in mice. Scopolamine (ED50 = 0.26 mg/kg) and two tricyclic antidepressants, desipramine (ED50 = 1.82 mg/kg) and IM/P/3/4 (ED50 = 8.95 mg/kg) completely antagonize 4-AP-induced hypothermia, whereas minaprine (0.1-0.25 mg/kg), a non-tricyclic antidepressant ...
G, Volterra, A, Lecci
openaire   +2 more sources

An Electroencephalographic Study of 4-Aminopyridine

Anesthesia & Analgesia, 1982
The electroencephalographic (EEG) effects of 4-aminopyridine (4-AP) given intravenously in therapeutic doses were studied in four conscious human volunteers. 4-AP (0.2 mg/kg) caused an increase of the occipital alpha peak frequency of 0.4 to 1.0 Hz. In the dose range of 0.2 to 0.3 mg/kg there was neither evidence for epileptic activity in the EEG nor ...
R L, Sia   +4 more
openaire   +4 more sources

INDO theoretical studies of 4-aminopyridine and protonated 4-aminopyridine

Journal of the Chemical Society, Perkin Transactions 2, 1975
Geometry optimized INDO calculations have been performed on 4-aminopyridine (2) and protonated 4-aminopyridine (1) in order to compare their optimized geometries, π-bond orders, C(4)–NH2 rotational barriers, charge densities, and π-electron distributions. It had previously been shown that 4-aminopyridine falls far off a linear correlation of ΔG° and ΔS°
Charles U. Pittman   +2 more
openaire   +1 more source

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