Results 221 to 230 of about 24,212 (246)

Determination of 4-aminopyridine in plasma

Analytical Biochemistry, 1981
Abstract Gas-liquid chromatographic procedures for the determination of 4-aminopyridine in human and animal plasma are reported. The procedures involve the addition of an internal standard 3-methyl-4-aminopyridine to plasma followed by extraction into methylene chloride/isopropranol under alkaline conditions.
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Distribution of the 4-aminopyridine derivative 3-methoxy-4-aminopyridime in mice

Neuropharmacology, 1989
The tissue distribution of [14C]3-Methoxy-4-aminopyridine was studied after intravenous administration in mice using whole body and microautoradiography. Dense accumulation was found in cholinergically innervated, secretory organs. High radioactivity was detected in the adrenal medulla suggesting that the observed excitement and hyperglycemia are due ...
S G, Berger, P G, Waser, A, Chang Sin-Ren   +2 more
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Does 4-aminopyridine “beat” downbeat nystagmus?

Journal of Neurology, Neurosurgery & Psychiatry, 2013
The flocculus of cerebellum inhibits the vestibular nuclei and keeps the eyes steady during downward gaze. Disinhibition of the flocculus leads to slow upward drift of the eyes, followed by corrective downward saccade—the ‘downbeat’—hence the name ‘downbeat’ nystagmus. Asymmetry in the vertical smooth pursuit pathway or, imbalance in the neural tone of
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4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity

Bioorganic & Medicinal Chemistry Letters, 2008
Several carbamate derivatives of 4-aminopyridine were synthesized and their anticholinesterase activity was evaluated. Compound 4d showed the highest inhibitory effect blocking non-competitively acetylcholinesterase and competitively butyrylcholinesterase.
SCIPIONE, Luigi, DE VITA, DANIELA, Alessandra Musella, Lisa Flammini, Simona Bertoni, Elisabetta Barocelli   +5 more
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4-Aminopyridine Potentiates Neostigmine and Pyridostigmine in Man

Anesthesiology, 1979
To elucidate the interaction of 4-aminopyridine with neostigmine and pyridostigmine, the authors studied 57 anesthetized surgical patients using a technique of constant infusion of pancuronium to quantitate antagonist activity. 4-Aminopyridine, 0.15 or 0.35 mg/kg, produced no antagonism, while 0.5 mg/kg produced a mean 24 +/- 6 per cent (peak ...
Miller, RD, Booij, LHDJ, Agoston, S, Crul, JF   +3 more
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A new calorimetric standard: 4-aminopyridine

Thermochimica Acta, 1977
Abstract The need for a new solution calorimetric standard is discussed. The standard proposed is 4-aminopyridine which is shown to be more satisfactory than the previously accepted standards of sodium hydroxide or trishydroxyaminomethane. The reaction is HClO 4 (aq) + 4–AP(aq)→4–APH + ClO − 4 (aq) with Δ H ° N (298.15 K) =11.164±0.011 kcal mol −1 .
Alan E. Van Til, Dennis C. Johnson
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Effects of 4-aminopyridine on neuromuscular transmission

Brain Research, 1978
4-Aminopyridine (4-AP) powerfully increases transmitter release from motor nerve terminals of rat and frog skeletal muscle in response to single nerve impulses. The drug also enhances transmitter release during repetitive nerve activity but, at D-tubocurarine-blocked endplates, only the first impulses cause increased transmitter release at stimulation ...
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4-Aminopyridine

Drugs of the Future, 1980
J. Castañer, D.M. Paton
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4-Aminopyridin (Fampridin)

Der Nervenarzt, 2010
L. Husseini, V.I. Leussink, B.C. Kieseier, H.-P. Hartung   +3 more
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Degradation of 4-aminopyridine in soil

Journal of Agricultural and Food Chemistry, 1976
P M, Betts, C W, Giddings, J R, Fleeker
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