Results 31 to 40 of about 4,514 (173)
Nopol-Based Quinoline Derivatives as Antiplasmodial Agents
Molecules, 2021 Malaria remains a significant cause of morbidity and mortality in Sub-Saharan Africa and South Asia. While clinical antimalarials are efficacious when administered according to local guidelines, resistance to every class of antimalarials is a persistent ...
Rogers J. Nyamwihura +4 more
doaj +1 more source
PLoS Neglected Tropical Diseases, 2021 BackgroundGlucose-6-phosphate dehydrogenase (G6PD) deficiency greatly hinders Plasmodium vivax malaria radical cure and further elimination due to 8-aminoquinolines-associated hemolysis.
Jose Diego Brito-Sousa +27 more
doaj +1 more source
Future Journal of Pharmaceutical Sciences, 2020 Background Based on bioisosteric similarities with thiacetazone, a series of 7-chloro-4-aminoquinoline derivatives have been designed and synthesized. The target compounds were elucidated by NMR, mass, and FTIR spectral data.
Shankar Alegaon +7 more
doaj +1 more source
Pharmaceuticals, 2021 8-Aminoquinolines (8-AQs) are an important class of anti-infective therapeutics. The monoamine oxidases (MAOs) play a key role in metabolism of 8-AQs. A major role for MAO-A in metabolism of primaquine (PQ), the prototypical 8-AQ antimalarial, has been ...
Narayan D. Chaurasiya +5 more
doaj +1 more source
Evaluation of α,β-unsaturated ketones as antileishmanial agents [PDF]
, 2015 In this study, we assessed the antileishmanial activity of 126 α,β-unsaturated ketones. The compounds NC901, NC884, and NC2459 showed high leishmanicidal activity for both the extracellular (50% effective concentration [EC(50)], 456 nM, 1,122 nM, and 20 ...
Beverley, Stephen M +6 more
core +2 more sources
Synthesis of 4-Aminoquinolines
, 1965 4-Anilinoquinolines have been prepared by cyclodehydration of \(\beta\)-anilinoacryloanilides with polyphosphoric acid.
A. K. Sen, (Miss) Kalyani Mitra
openaire +1 more source
Development of New Anti-Virulence Agents to Tackle Multi-Resistant Pseudomonas aeruginosa
Medical Sciences Forum, 2022 The multi-resistant opportunistic bacterium Pseudomonas aeruginosa has been identified by the WHO as one of the most threatening pathogens of our time and a priority for the development of new treatments.
Marie Hanot, Elodie Lohou, Pascal Sonnet
doaj +1 more source
Modulation of Antimalarial Activity at a Putative Bisquinoline Receptor in vivo Using Fluorinated Bisquinolines [PDF]
Antimalarials can interact with heme covalently, by - interactions or hydrogen bonding. Consequently, the prototropy of 4-aminoquinolines and quinoline methanols was investigated using quantum mechanics.
Alizadeh, S +14 more
core +1 more source
In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids. [PDF]
, 2016 Malaria is a parasitic tropical disease that kills around 600,000 patients every year. The emergence of resistant Plasmodium falciparum parasites to artemisinin-based combination therapies (ACTs) represents a significant public health threat, indicating ...
Cojean, S +10 more
core +5 more sources
International Journal of Infectious Diseases, 2023 Objectives: This study aimed to investigate the evolution of Plasmodium falciparum antimalarial drug resistance markers by comparing the pre- and post-adoption of artemisinin-based combination therapies (ACTs) in Yaounde, Cameroon. Methods: The molecular
Peter Thelma Ngwa Niba +14 more
doaj +1 more source