Results 21 to 30 of about 50 (50)

Recent developments in antimalarial activities of 4-aminoquinoline derivatives

European Journal of Medicinal Chemistry, 2023
Malaria is the fifth most lethal parasitic infection in the world. Antimalarial medications have played a crucial role in preventing and eradicating malaria. Numerous heterocyclic moieties have been incorporated into the creation of effective antimalarial drugs.
Lekkala Ravindar, Siti Aishah Hasbullah, K.P. Rakesh, Nurul Izzaty Hassan   +3 more
openaire   +2 more sources

4‐Aminoquinoline Derivatives as Potential Antileishmanial Agents

Chemical Biology & Drug Design, 2015
The leishmanicidal activity of a series of 4‐aminoquinoline (AMQ) derivatives was assayed against Leishmania amazonensis. This activity against the intracellular parasite was found stronger than for L. amazonensis promastigotes. Neither compound was cytotoxic against macrophages.
Luciana M R, Antinarelli, Rafael M P, Dias, Isabela O, Souza, Wallace P, Lima, Jacy, Gameiro, Adilson D, da Silva, Elaine S, Coimbra   +6 more
openaire   +2 more sources

4-Aminoquinolines as AChE Inhibitors

1998
A systematic analysis of the tacrine-TcAChE complex X-ray structure2 has been carried out, in conjunction with other available crystallographic data, with the aim of identifying possible areas for selective inhibitor design.
P. D. Bentley, F. Earley, R. J. Fletcher, A. Kinkaid, T. Lewis, B. Pirard, J. Taylor, R. C. Viner   +7 more
openaire   +1 more source

4-Aminoquinolines and Mannich Bases

1984
The antimalarial 4-aminoquinolines and Mannich bases have been compiled and/or discussed in a number of compendia and reviews. These reviews have, for the most part, considered only those drugs or compounds that have shown an activity sufficient to focus broad attention upon them.
T. R. Sweeney, R. O. Pick
openaire   +1 more source

Electrophilic Tropylation of Aminopyridines and 4-Aminoquinoline

Russian Journal of General Chemistry, 2019
The reactions of 2-, 3-, 4-aminopyridines or 4-aminoquinoline with hydrolytically stable tropylium salts (perchlorate or tetrafluoroborate) have afforded N-(1′-cyclohepta-2′,4′,6′-trienyl)-2-aminopyridine, N-(1′-cyclohepta-2′,4′,6′-trienyl)-3-aminopyridine, N-(1′-cyclohepta-2′,4′, 6′-trienyl)-4-aminopyridine, and N-(1′-cyclohepta-2′,4′,6′-trienyl)-4 ...
L. P. Yunnikova, Yu. E. Likhareva, V. V. Esenbaeva   +2 more
openaire   +1 more source

Synthesis of 4‐aminoquinoline‐1,2,3‐triazole and 4‐aminoquinoline‐1,2,3‐triazole‐1,3,5‐triazine Hybrids as Potential Antimalarial Agents

Chemical Biology & Drug Design, 2011
We report herein synthesis of a series of 4‐aminoquinoline‐1,2,3‐triazole and 4‐aminoquinoline‐1,2,3‐triazole‐1,3,5‐triazine hybrids and evaluate their antimalarial activity against D6 and W2 strains of Plasmodium falciparum. To study the structure–activity relationship of substituted 4‐aminoquinoline–based hybrids, 34 structurally diverse compounds ...
Sunny, Manohar, Shabana I, Khan, Diwan S, Rawat   +2 more
openaire   +2 more sources

4-Aminoquinoline Based Molecular Hybrids as Antimalarials: An Overview

Current Topics in Medicinal Chemistry, 2014
In recent times, the novel concept of generating hybrid molecules by pharmacophoric hybridisation approach is fast becoming an alternative to other existing strategies of drug development. These hybrids also known as 'dual drugs' or 'double drugs' are especially found to be effective in overcoming drug resistance problems.
Sunny, Manohar, Mohit, Tripathi, Diwan S, Rawat   +2 more
openaire   +2 more sources

QSAR Models for Anti-Malarial Activity of 4-Aminoquinolines

Current Computer Aided-Drug Design, 2014
In the present study, predictive quantitative structure - activity relationship (QSAR) models for anti-malarial activity of 4-aminoquinolines have been developed. CORAL, which is freely available on internet (http://www.insilico.eu/coral), has been used as a tool of QSAR analysis to establish statistically robust QSAR model of anti-malarial activity of
Vijay H, Masand, Andrey A, Toropov, Alla P, Toropova, Devidas T, Mahajan   +3 more
openaire   +2 more sources

4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity

Bioorganic & Medicinal Chemistry, 2005
A set of quinolizidinyl and quinolizidinylalkyl derivatives of 4-amino-7-chloroquinoline and of 9-amino-6-chloro-2-methoxyacridine were prepared and tested in vitro against CQ-sensitive (D-10) and CQ-resistant (W-2) strains of Plasmodium falciparum. All compounds but one exerted significant antimalarial activity.
A. Sparatore, N. Basilico, S. Parapini, S. Romeo, F. Novelli, F. Sparatore, D. Taramelli   +6 more
openaire   +3 more sources

4-Aminoquinolines:  Novel Nociceptin Antagonists with Analgesic Activity

Journal of Medicinal Chemistry, 2000
Small-molecule nociceptin antagonists were synthesized to examine their therapeutic potential. After a 4-aminoquinoline derivative was found to bind with the human ORL(1) receptor, a series of 4-aminoquinolines and related compounds were synthesized and their binding was evaluated.
H, Shinkai, T, Ito, T, Iida, Y, Kitao, H, Yamada, I, Uchida   +5 more
openaire   +2 more sources