Results 1 to 10 of about 50 (50)
Acta Crystallographica Section E Structure Reports Online, 2007 The title compound, C11H10N2O, a potential antitumour drug, crystallizes with two molecules in the asymmetric unit. The 4-amino N atom is strongly conjugated with the quinoline ring involving the 3-carbonyl group. As a result, the molecule is almost planar.
Jan Lokaj +4 more
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Synthesis of 4-Aminoquinolines
, 1965 4-Anilinoquinolines have been prepared by cyclodehydration of \(\beta\)-anilinoacryloanilides with polyphosphoric acid.
A. K. Sen, (Miss) Kalyani Mitra
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Parallel Synthesis and Antimalarial Screening of a 4-Aminoquinoline Library [PDF]
Journal of Combinatorial Chemistry, 2004 Due to growing problems with drug resistance, there is an outstanding need for new, cost-effective drugs for the treatment of malaria. The 4-aminoquinolines have provided a number of useful antimalarials, and Plasmodium falciparum, the causative organism for the most deadly form of human malaria, is generally slow to develop resistance to these drugs ...
Peter B, Madrid +3 more
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Synthesis and Antimalarial Activities of Cyclen 4-Aminoquinoline Analogs [PDF]
Antimicrobial Agents and Chemotherapy, 2009 ABSTRACT In an attempt to augment the efficacy of 7-chloro 4-aminoquinoline analogs and also to overcome resistance to antimalarial agents, we synthesized three cyclen (1,4,7,10-tetraazacyclododecane) analogs of chloroquine [a bisquinoline derivative, 7-chloro-4-(1,4,7,10-tetraaza-cyclododec-1-yl)-quinoline HBr, and a 7-chloro-4-(
M O Faruk, Khan +5 more
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4-aminoquinolines: An Overview of Antimalarial Chemotherapy
Medicinal chemistry, 2016 Malaria is a major health problem and Plasmodium falciparum strain resistance to existing antimalarials drugs made the current approach inadequate for treatment of malaria. Drug development directed against malaria is generally targeting blood schizonts.
Shreekant Deshpande, Bhimanna Kuppast
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Inhibition of Intramacrophage Growth ofPenicillium marneffeiby 4-Aminoquinolines [PDF]
Antimicrobial Agents and Chemotherapy, 2001 ABSTRACTThe antimicrobial activities of chloroquine (CQ) and several 4-aminoquinoline drugs were tested againstPenicillium marneffei, an opportunistic fungus that invades and grows inside macrophages and causes disseminated infection in AIDS patients. Human THP1 and mouse J774 macrophages were infected in vitro withP.
D. Taramelli +5 more
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ON- 2-PHENYL-4-AMINOQUINOLINE DERIVATIVES.
, 1939 Certain 2-pheny1-4-(dialkylamino-4'-sulphonamidophenyl-, and arnidobenzene- sulphonyl-) aminoquinolines have been described The yield of the condensation product is invariably poor.
U. P. BASU, P. K. DAS-GUPTA
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4-Aminoquinoline: a comprehensive review of synthetic strategies
Frontiers in Chemistry4-Aminoquinoline is an important scaffold due to its variety of applications in medicinal, synthetic organic, and industrial chemistry. It has gained great relevance for the development of selective and potent leishmanicidal agents targeting parasite mitochondria, agonists and antagonists of Toll-like receptors (TLRs), antimalarials, and anticancer ...
Francisco Delgado +4 more
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Synthesis and in vitro cytotoxicity evaluation of 4-aminoquinoline derivatives
Biomedicine & Pharmacotherapy, 2008 A series of 4-aminoquinoline derivatives were synthesized by the reaction of 4-chloro-7-substituted-quinolines with the corresponding mono/dialkyl amines. The structures of the synthesized compounds were confirmed by NMR and FAB-MS spectral and elemental analyses.
Zhang, Haiwen +4 more
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