Results 31 to 40 of about 50 (50)

4-Aminoquinolines—Past, present, and future; A chemical perspective

Pharmacology & Therapeutics, 1998
The 4-aminoquinoline chloroquine (1) can be considered to be one of the most important synthetic chemotherapeutic agents in history. Since its discovery, chloroquine has proved to be a highly effective, safe, and well-tolerated drug for the treatment and prophylaxis of malaria.
P M, O'Neill, P G, Bray, S R, Hawley, S A, Ward, B K, Park   +4 more
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A Medicinal Chemistry Perspective on 4-Aminoquinoline Antimalarial Drugs

Current Topics in Medicinal Chemistry, 2006
A broad overview is presented describing the current knowledge and the ongoing research concerning the 4-aminoquinolines (4AQ) as chemotherapeutic antimalarial agents. Included are discussions of mechanism of action, structure activity relationships (SAR), chemistry, metabolism and toxicity and parasite resistance mechanisms.
Paul M, O'Neill, Stephen A, Ward, Neil G, Berry, J Prince, Jeyadevan, Giancarlo A, Biagini, Egbaleh, Asadollaly, B Kevin, Park, Patrick G, Bray   +7 more
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Giant miniature endplate potentials induced by 4‐aminoquinoline

Acta Physiologica Scandinavica, 1982
In experiments on the isolated extensor digitorum longus muscle of the rat it was shown that 4‐aminoquinoline (125–250 μM) altered the amplitude distribution of spontaneous miniature endplate potentials to include a large portion of giant miniature endplate potentials with slow rise and decay times.
J, Molgó, S, Gomez, R L, Polak, S, Thesleff   +3 more
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NMR proof of the structure of 4‐aminoquinolines and pyridines

Journal of Heterocyclic Chemistry, 1968
AbstractNmr spectra of a number of 4‐N‐alkylaminoquinolines and 4‐N‐alkylaminopyridines show coupling between hydrogen of the amino group and α‐hydrogen on the alkyl group. No such coupling would be observed if the hydrogen were on heterocyclic nitrogen.
John C. Craig, D. E. Pearson
openaire   +1 more source

Hydrophobicity and antifilarial activities of 4-aminoquinolines.

The Southeast Asian journal of tropical medicine and public health, 1983
The apparent partition coefficients (Papp.) of eight 4-aminoquinolines in 1-octanol/pH 7.4 buffered solutions have been determined and correlated with their reported antifilarial activities. Antifilarial activity appears to be present only in those 4-aminoquinolines which have log Papp. values falling within a narrow range of 2.8 to 3.2.
M L, Go, T L, Ngiam, G, Becket, S L, Leung   +3 more
openaire   +1 more source

The Resistance of Falciparum Malaria in Africa to 4-Aminoquinolines and Antifolates

Scandinavian Journal of Infectious Diseases, 1990
Falciparum malaria cannot be eradicated from sub-Saharan Africa with present technology. The mainstay of malaria control in this situation is treatment of fever cases with chloroquine, aiming principally at reduction of mortality. The efficacy of this policy is now endangered because of the appearance and spread of chloroquine-resistance on the African
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Quinolines VI. Some 4-Aminoquinoline Derivatives

Journal of the American Chemical Society, 1948
E A, STECK, L L, HALLOCK, C M, SUTER
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4-Aminoquinolines

1984
E. W. McChesney, C. D. Fitch
openaire   +1 more source

409. The nitration of 4-aminoquinoline

Journal of the Chemical Society (Resumed), 1948
J. C. E. Simpson, P. H. Wright
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Synthesis and hypotensive properties of new 4-aminoquinolines

Journal of Medicinal Chemistry, 1971
G C, Wright, E J, Watson, F F, Ebetino, G, Lougheed, B F, Stevenson, A, Winterstein, R K, Bickerton, R P, Halliday, D T, Pals   +8 more
openaire   +2 more sources