Results 51 to 60 of about 34,044 (268)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

4-H Clubs

, 1929
This publication provides information on the opportunities and benefits provided by 4-H club activities such as projects, instruction, demonstration, exhibits, camps, games, awards, and educational trips.
South Dakota State University Cooperative Extension
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

4-H food preservation clubs

, 2011
Circular containing overall rules for 4-H food preservation clubs, and requirements, home work, and exhibit guidelines for units I ...

core  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

FFA and 4-H Clubs

, 1964
Attending the National Western Livestock Show from local 4-H and FFA clubs were Cherry Rasmussen, Sheila Wall, Rhett Searle, Larry Allred, James Wardell, Lloyd Hallett, Harlan Wilkins and Keith Dagley.
Thorne, L.C.
core  

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Basic Parliamentary Procedure for 4-H Clubs

, 2008
This publication provides outline and benefits to using Parliamentary Procedure in 4-H ...
Carter, Donna
core  

A gender-sensitised weight loss and healthy living programme for overweight and obese men delivered by Scottish Premier League football clubs (FFIT):a pragmatic randomised controlled trial [PDF]

, 2014
Background: The prevalence of male obesity is increasing but few men take part in weight loss programmes. We assessed the effect of a weight loss and healthy living programme on weight loss in football (soccer) fans.
White, Alan, Leishman, Jim, Donnan, Peter T, Rauchhaus, Petra, Gray, Cindy M., Lieshman, Jim, Wyke, S, Treweek, S, Grieve, E, Brady, Adrian, Grieve, Eleanor, Brady, A, Donnan, PT, Anderson, AS, Anderson, Annie S, Gray, CM, Treweek, Shaun, Donnan, Peter T.; id_orcid, Rauchhaus, P, Fenwick, Elisabeth, Fenwick, E, Bunn, Christopher, Leishman, J, Miller, E, Mutrie, N, White, A, Gray, Cindy, Hunt, K, Hunt, Kate, Anderson, Annie S., Mutrie, Nanette, Miller, Euan, Gray, Cindy M, Wyke, Sally, Anderson, Annie S.; id_orcid, Donnan, Peter T., Bunn, C   +36 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source