Results 151 to 160 of about 107,357,802 (270)

Community-minded, adolescent-driven: addressing behavioral health disparities through youth participatory research designs. [PDF]

Front Public Health
Hernandez JM, Palafu T, Pascual S, Primack Z, Madrigal G, Okamoto MT, Tano HJK, Almanza P, Besson C, Ito M, Ciao AC, Opara I, Okamura KH.   +12 more
europepmc   +1 more source

Gut Microbiota‐Derived Indole‐3‐Acetaldehyde Contributes to the Disease‐Alleviating Effects of Kurarinone in Experimental Autoimmune Encephalomyelitis

Advanced Science, EarlyView.
Kurarinone ameliorates EAE via the gut microbiota‐indole‐3‐acetaldehyde‐AhR axis. Kurarinone reshapes gut microbiota and increases Akkermansia muciniphila, which promotes intestinal indole‐3‐acetaldehyde production. Indole‐3‐acetaldehyde crosses the intestinal barrier, activates AhR in CD4+ T cells, upregulates SOCS1/3, inhibits JAK2 and STAT3/4 ...
Xinyan Han, Jiaqi Ding, Zonghao Pan, Weitai He, Xue Kang, Cong Zhao, Yi Li, Di Wu, Hongzeng Li, Kaixi Ren, Jiaji Lin, Jun Guo   +11 more
wiley   +1 more source

Co-Designing Wellbeing Initiatives With Rural Adolescents: What Works, What Doesn't, and Why. [PDF]

Health Promot J Austr
Kernot J, Kiriam S, Seekamp S, Little K, Hunt K, Lister E, Maher C, Brinsley J.   +7 more
europepmc   +1 more source

Noninvasive Detection and Subtyping of Esophageal Cancer by Circulating Cell‐Free mtDNA Fragmentomics: A Multi‐Center Validation Study

Advanced Science, EarlyView.
Circulating cell‐free mitochondrial DNA provides a robust, noninvasive platform for early detection and histological subtyping of esophageal cancer. This large multi‐center study validates consistently high accuracy across ethnically and geographically diverse cohorts, demonstrating strong potential to transform clinical management. ABSTRACT Esophageal
Yue Liu, Wenying Yang, Yu Li, Siyuan Wang, Xiang Li, Fan Peng, Miao Dang, Huanqin Zhang, Huanmin Jiao, Yuqing Yang, Zhaoquan Su, Xiumin Ma, Zhiyun Gong, Renquan Lu, Jinliang Xing, Yang Liu   +15 more
wiley   +1 more source

Correction: Immunomodulatory effects of HUC-MSCs therapy: enhancing adaptive and innate immune responses in aging frailty. [PDF]

Front Immunol
Huang C, Zhu Y, Gong X, Feng S, Huo G, Liu H, Jiang H, Liu Z.   +7 more
europepmc   +1 more source

Arhgef1 Deletion Disrupts Early Cortical Neurogenesis via PAK1 Overactivation and Causes Motor Dysfunction in Adulthood

Advanced Science, EarlyView.
ARHGEF1 plays a pivotal role in both embryonic cortical neurogenesis and adult motor function. During early development, it governs genesis of deep‐layer cortical neurons by negatively regulating RAC1/CDC42‐PAK1‐Cofilin signaling. In adulthood, ARHGEF1 is important for the maintenance of neuronal morphology and activity in the motor cortex, ensuring ...
Liuren Li, Xuanyue Ma, Zhenyu Ding, Bang Sun, Linglin Liu, Hei Matthew Yip, Wei Wang, Tianying Wu, Yuan Guo, Yinghui Peng, Shiqing Zhang, Jacque Pak Kan Ip, Li Zhang, Keshen Li, Lei Shi   +14 more
wiley   +1 more source

Development, Implementation, and Evaluation of a Proof of Concept, Food- and Nutrition-Focused Science Education Program for Youth in Public Libraries. [PDF]

Public Libr Q (N Y)
Holben DH, Duffrin MW.
europepmc   +1 more source

Biomimetic Nanoplatform for Fibrosis Remodeling and Anti‐PD‐1 Potentiation via Cu+/Ca2+ Ion Dysregulation and TGF‐β Inhibition in PDAC

Advanced Science, EarlyView.
A biomimetic nanoplatform (RPm@CC‐LY) remodels fibrotic stroma via sustained TGF‐β inhibition, triggers oxidative stress and apoptosis through Cu+‐mediated Fenton chemistry and Ca2+ overload, and reprograms macrophages and dendritic cells to boost CD8+ T cell infiltration.
Jianmei Li, Qinlong Wen, Jie Dai, Li Yang, Feng Xiong, Zhigong Wei, Xingchen Peng   +6 more
wiley   +1 more source

Bridging Culture and Prevention: Facilitators of Success in a Culturally Grounded Drug Prevention Program for Rural Hawaiian Youth. [PDF]

Transl Issues Psychol Sci
Primack Z, Palafu T, Goshgarian-Miller S, Liu M, Chertavian C, Rapadas CC, Yamane R, An KJ, Chin SK, Okamoto SK, Okamura KH.   +10 more
europepmc   +1 more source

Cascade Desolvation and Conversion Reaction Driven by Self‐Tandem Catalysis for Wide‐Temperature Li‐S Batteries

Advanced Science, EarlyView.
A self‐tandem catalysis accelerating cascade reaction strategy is pioneered through constructing electron‐adjustable atom‐level Ce as the self‐tandem catalyst to lower energy barriers for fast Li+ desolvation and sequential sulfur conversion kinetics. The catalyzed cells operate effectively over a wide‐temperature range from 0 to ‐30 °C, delivering a ...
Jing Zhang, Shikai Yin, Mannan Yang, Hui Li, Caiyin You, Na Tian, Zhenjiang Cao, Yongzheng Zhang, Ruixian Duan, Hongzhen Lin, Jian Wang   +10 more
wiley   +1 more source